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H1-1 (H1.1 linker histone, cluster member)

Identity

Alias (NCBI)H1.1
H1A
H1F1
HIST1
HIST1H1A
HGNC (Hugo) H1-1
HGNC Alias symbH1.1
H1a
HGNC Previous nameH1F1
 HIST1H1A
HGNC Previous nameH1 histone family, member 1
 histone 1, H1a
 histone cluster 1, H1a
 histone cluster 1 H1 family member a
LocusID (NCBI) 3024
Atlas_Id 124
Location 6p22.2  [Link to chromosome band 6p22]
Location_base_pair Starts at 26017032 and ends at 26017787 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  3q27 rearrangements (BCL6) in non Hodgkin lymphoma::t(3;Var)(q27;Var) in non Hodgkin lymphoma
t(3;14)(q27;q32) IGH/BCL6::t(2;3)(p12;q27) IGK/BCL6::t(3;22)(q27;q11) IGL/BCL6


External links

Nomenclature
HGNC (Hugo)H1-1   4715
Cards
Entrez_Gene (NCBI)H1-1  3024  H1.1 linker histone, cluster member
AliasesH1.1; H1A; H1F1; HIST1; 
HIST1H1A
GeneCards (Weizmann)H1-1
Ensembl hg19 (Hinxton)ENSG00000124610 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124610 [Gene_View]  ENSG00000124610 [Sequence]  chr6:26017032-26017787 [Contig_View]  H1-1 [Vega]
ICGC DataPortalENSG00000124610
TCGA cBioPortalH1-1
AceView (NCBI)H1-1
Genatlas (Paris)H1-1
WikiGenes3024
SOURCE (Princeton)H1-1
Genetics Home Reference (NIH)H1-1
Genomic and cartography
GoldenPath hg38 (UCSC)H1-1  -     chr6:26017032-26017787 -  -   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)H1-1  -     -   [Description]    (hg19-Feb_2009)
GoldenPathH1-1 - - [CytoView hg19]  H1-1 - - [CytoView hg38]
ImmunoBaseENSG00000124610
genome Data Viewer NCBIH1-1 [Mapview hg19]  
OMIM142709   
Gene and transcription
Genbank (Entrez)BC069492 BC101593 BC112140
RefSeq transcript (Entrez)NM_005325
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)H1-1
Alternative Splicing GalleryENSG00000124610
Gene ExpressionH1-1 [ NCBI-GEO ]   H1-1 [ EBI - ARRAY_EXPRESS ]   H1-1 [ SEEK ]   H1-1 [ MEM ]
Gene Expression Viewer (FireBrowse)H1-1 [ Firebrowse - Broad ]
GenevisibleExpression of H1-1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3024
GTEX Portal (Tissue expression)H1-1
Human Protein AtlasENSG00000124610-H1-1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02539   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02539  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02539
Splice isoforms : SwissVarQ02539
PhosPhoSitePlusQ02539
Domaine pattern : Prosite (Expaxy)H15 (PS51504)   
Domains : Interpro (EBI)Histone_H1/H5_H15    Histone_H5    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)Linker_histone (PF00538)   
Domain families : Pfam (NCBI)pfam00538   
Domain families : Smart (EMBL)H15 (SM00526)  
Conserved Domain (NCBI)H1-1
DMDM Disease mutations3024
Blocks (Seattle)H1-1
SuperfamilyQ02539
Human Protein Atlas [tissue]ENSG00000124610-H1-1 [tissue]
Peptide AtlasQ02539
HPRD00820
IPIIPI00217469   
Protein Interaction databases
DIP (DOE-UCLA)Q02539
IntAct (EBI)Q02539
FunCoupENSG00000124610
BioGRIDH1-1
STRING (EMBL)H1-1
ZODIACH1-1
Ontologies - Pathways
QuickGOQ02539
Ontology : AmiGOnucleosome  nuclear chromatin  nuclear chromatin  double-stranded DNA binding  protein binding  nucleus  nuclear euchromatin  nuclear euchromatin  nucleosome assembly  regulation of transcription, DNA-templated  spermatogenesis  heparin binding  cell surface  nucleosome positioning  chromosome condensation  chromatin DNA binding  nucleosomal DNA binding  negative regulation of chromatin silencing  vesicle  host cell nucleus  negative regulation of DNA recombination  positive regulation of receptor-mediated endocytosis  
Ontology : EGO-EBInucleosome  nuclear chromatin  nuclear chromatin  double-stranded DNA binding  protein binding  nucleus  nuclear euchromatin  nuclear euchromatin  nucleosome assembly  regulation of transcription, DNA-templated  spermatogenesis  heparin binding  cell surface  nucleosome positioning  chromosome condensation  chromatin DNA binding  nucleosomal DNA binding  negative regulation of chromatin silencing  vesicle  host cell nucleus  negative regulation of DNA recombination  positive regulation of receptor-mediated endocytosis  
NDEx NetworkH1-1
Atlas of Cancer Signalling NetworkH1-1
Wikipedia pathwaysH1-1
Orthology - Evolution
OrthoDB3024
GeneTree (enSembl)ENSG00000124610
Phylogenetic Trees/Animal Genes : TreeFamH1-1
HOGENOMQ02539
Homologs : HomoloGeneH1-1
Homology/Alignments : Family Browser (UCSC)H1-1
Gene fusions - Rearrangements
Fusion : QuiverH1-1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerH1-1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)H1-1
dbVarH1-1
ClinVarH1-1
MonarchH1-1
1000_GenomesH1-1 
Exome Variant ServerH1-1
GNOMAD BrowserENSG00000124610
Varsome BrowserH1-1
Genetic variants : HAPMAP3024
Genomic Variants (DGV)H1-1 [DGVbeta]
DECIPHERH1-1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisH1-1 
Mutations
ICGC Data PortalH1-1 
TCGA Data PortalH1-1 
Broad Tumor PortalH1-1
OASIS PortalH1-1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDH1-1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch H1-1
DgiDB (Drug Gene Interaction Database)H1-1
DoCM (Curated mutations)H1-1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)H1-1 (select a term)
intoGenH1-1
Cancer3DH1-1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142709   
Orphanet
DisGeNETH1-1
MedgenH1-1
Genetic Testing Registry H1-1
NextProtQ02539 [Medical]
TSGene3024
GENETestsH1-1
Target ValidationH1-1
Huge Navigator H1-1 [HugePedia]
snp3D : Map Gene to Disease3024
BioCentury BCIQH1-1
ClinGenH1-1
Clinical trials, drugs, therapy
Protein Interactions : CTD3024
Clinical trialH1-1
Miscellaneous
canSAR (ICR)H1-1 (select the gene name)
HarmonizomeH1-1
DataMed IndexH1-1
Probes
Litterature
PubMed156 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineH1-1
EVEXH1-1
GoPubMedH1-1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:13:43 CEST 2020

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