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H1-2 (H1.2 linker histone, cluster member)

Identity

Alias_namesH1F2
HIST1H1C
H1 histone family, member 2
histone 1, H1c
histone cluster 1, H1c
histone cluster 1 H1 family member c
Alias_symbol (synonym)H1.2
H1s-1
H1c
Other aliasH1C
HGNC (Hugo) H1-2
LocusID (NCBI) 3006
Atlas_Id 53900
Location 6p22.2  [Link to chromosome band 6p22]
Location_base_pair Starts at 26055740 and ends at 26056471 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)H1-2   4716
Cards
Entrez_Gene (NCBI)H1-2  3006  H1.2 linker histone, cluster member
AliasesH1.2; H1C; H1F2; H1s-1; 
HIST1H1C
GeneCards (Weizmann)H1-2
Ensembl hg19 (Hinxton)ENSG00000187837 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000187837 [Gene_View]  ENSG00000187837 [Sequence]  chr6:26055740-26056471 [Contig_View]  H1-2 [Vega]
ICGC DataPortalENSG00000187837
TCGA cBioPortalH1-2
AceView (NCBI)H1-2
Genatlas (Paris)H1-2
WikiGenes3006
SOURCE (Princeton)H1-2
Genetics Home Reference (NIH)H1-2
Genomic and cartography
GoldenPath hg38 (UCSC)H1-2  -     chr6:26055740-26056471 -  -   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)H1-2  -     -   [Description]    (hg19-Feb_2009)
GoldenPathH1-2 - - [CytoView hg19]  H1-2 - - [CytoView hg38]
ImmunoBaseENSG00000187837
Mapping of homologs : NCBIH1-2 [Mapview hg19]  H1-2 [Mapview hg38]
OMIM142710   
Gene and transcription
Genbank (Entrez)AB451259 AB451385 AK290947 BC002649 D28457
RefSeq transcript (Entrez)NM_005319
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)H1-2
Cluster EST : UnigeneHs.7644 [ NCBI ]
CGAP (NCI)Hs.7644
Alternative Splicing GalleryENSG00000187837
Gene ExpressionH1-2 [ NCBI-GEO ]   H1-2 [ EBI - ARRAY_EXPRESS ]   H1-2 [ SEEK ]   H1-2 [ MEM ]
Gene Expression Viewer (FireBrowse)H1-2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3006
GTEX Portal (Tissue expression)H1-2
Human Protein AtlasENSG00000187837-H1-2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16403   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP16403  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16403
Splice isoforms : SwissVarP16403
PhosPhoSitePlusP16403
Domaine pattern : Prosite (Expaxy)H15 (PS51504)   
Domains : Interpro (EBI)Histone_H1/H5_H15    Histone_H5    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)Linker_histone (PF00538)   
Domain families : Pfam (NCBI)pfam00538   
Domain families : Smart (EMBL)H15 (SM00526)  
Conserved Domain (NCBI)H1-2
DMDM Disease mutations3006
Blocks (Seattle)H1-2
SuperfamilyP16403
Human Protein Atlas [tissue]ENSG00000187837-H1-2 [tissue]
Peptide AtlasP16403
HPRD07514
IPIIPI00217465   
Protein Interaction databases
DIP (DOE-UCLA)P16403
IntAct (EBI)P16403
FunCoupENSG00000187837
BioGRIDH1-2
STRING (EMBL)H1-2
ZODIACH1-2
Ontologies - Pathways
QuickGOP16403
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  nucleosome  nuclear chromatin  double-stranded DNA binding  RNA binding  protein binding  nucleus  nucleus  nuclear euchromatin  nuclear euchromatin  nucleosome assembly  regulation of transcription, DNA-templated  nucleosome positioning  chromosome condensation  chromatin DNA binding  nucleosomal DNA binding  negative regulation of chromatin silencing  transcriptionally active chromatin  negative regulation of DNA recombination  histone H3-K4 trimethylation  histone H3-K27 trimethylation  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  nucleosome  nuclear chromatin  double-stranded DNA binding  RNA binding  protein binding  nucleus  nucleus  nuclear euchromatin  nuclear euchromatin  nucleosome assembly  regulation of transcription, DNA-templated  nucleosome positioning  chromosome condensation  chromatin DNA binding  nucleosomal DNA binding  negative regulation of chromatin silencing  transcriptionally active chromatin  negative regulation of DNA recombination  histone H3-K4 trimethylation  histone H3-K27 trimethylation  
NDEx NetworkH1-2
Atlas of Cancer Signalling NetworkH1-2
Wikipedia pathwaysH1-2
Orthology - Evolution
OrthoDB3006
GeneTree (enSembl)ENSG00000187837
Phylogenetic Trees/Animal Genes : TreeFamH1-2
HOGENOMP16403
Homologs : HomoloGeneH1-2
Homology/Alignments : Family Browser (UCSC)H1-2
Gene fusions - Rearrangements
Fusion : QuiverH1-2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerH1-2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)H1-2
dbVarH1-2
ClinVarH1-2
1000_GenomesH1-2 
Exome Variant ServerH1-2
ExAC (Exome Aggregation Consortium)ENSG00000187837
GNOMAD BrowserENSG00000187837
Varsome BrowserH1-2
Genetic variants : HAPMAP3006
Genomic Variants (DGV)H1-2 [DGVbeta]
DECIPHERH1-2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisH1-2 
Mutations
ICGC Data PortalH1-2 
TCGA Data PortalH1-2 
Broad Tumor PortalH1-2
OASIS PortalH1-2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDH1-2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch H1-2
DgiDB (Drug Gene Interaction Database)H1-2
DoCM (Curated mutations)H1-2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)H1-2 (select a term)
intoGenH1-2
Cancer3DH1-2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142710   
Orphanet
DisGeNETH1-2
MedgenH1-2
Genetic Testing Registry H1-2
NextProtP16403 [Medical]
TSGene3006
GENETestsH1-2
Target ValidationH1-2
Huge Navigator H1-2 [HugePedia]
snp3D : Map Gene to Disease3006
BioCentury BCIQH1-2
ClinGenH1-2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3006
Chemical/Pharm GKB GenePA29094
Clinical trialH1-2
Miscellaneous
canSAR (ICR)H1-2 (select the gene name)
DataMed IndexH1-2
Probes
Litterature
PubMed120 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineH1-2
EVEXH1-2
GoPubMedH1-2
iHOPH1-2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jan 27 14:44:58 CET 2020

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