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H1-4 (H1.4 linker histone, cluster member)

Identity

Alias_namesH1F4
HIST1H1E
H1 histone family, member 4
histone 1, H1e
histone cluster 1, H1e
histone cluster 1 H1 family member e
Alias_symbol (synonym)H1.4
H1e
H1s-4
Other aliasH1E
RMNS
dJ221C16.5
HGNC (Hugo) H1-4
LocusID (NCBI) 3008
Atlas_Id 53757
Location 6p22.2  [Link to chromosome band 6p22]
Location_base_pair Starts at 26156331 and ends at 26157115 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)H1-4   4718
Cards
Entrez_Gene (NCBI)H1-4  3008  H1.4 linker histone, cluster member
AliasesH1.4; H1E; H1F4; H1s-4; 
HIST1H1E; RMNS; dJ221C16.5
GeneCards (Weizmann)H1-4
Ensembl hg19 (Hinxton)ENSG00000168298 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168298 [Gene_View]  ENSG00000168298 [Sequence]  chr6:26156331-26157115 [Contig_View]  H1-4 [Vega]
ICGC DataPortalENSG00000168298
TCGA cBioPortalH1-4
AceView (NCBI)H1-4
Genatlas (Paris)H1-4
WikiGenes3008
SOURCE (Princeton)H1-4
Genetics Home Reference (NIH)H1-4
Genomic and cartography
GoldenPath hg38 (UCSC)H1-4  -     chr6:26156331-26157115 +  -   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)H1-4  -     -   [Description]    (hg19-Feb_2009)
GoldenPathH1-4 - - [CytoView hg19]  H1-4 - - [CytoView hg38]
ImmunoBaseENSG00000168298
Mapping of homologs : NCBIH1-4 [Mapview hg19]  H1-4 [Mapview hg38]
OMIM142220   617537   
Gene and transcription
Genbank (Entrez)AK313681 BC055095 BC096168 BC096169 BC096170
RefSeq transcript (Entrez)NM_005321
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)H1-4
Alternative Splicing GalleryENSG00000168298
Gene ExpressionH1-4 [ NCBI-GEO ]   H1-4 [ EBI - ARRAY_EXPRESS ]   H1-4 [ SEEK ]   H1-4 [ MEM ]
Gene Expression Viewer (FireBrowse)H1-4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3008
GTEX Portal (Tissue expression)H1-4
Human Protein AtlasENSG00000168298-H1-4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10412   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10412  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10412
Splice isoforms : SwissVarP10412
PhosPhoSitePlusP10412
Domaine pattern : Prosite (Expaxy)H15 (PS51504)   
Domains : Interpro (EBI)Histone_H1/H5_H15    Histone_H5    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)Linker_histone (PF00538)   
Domain families : Pfam (NCBI)pfam00538   
Domain families : Smart (EMBL)H15 (SM00526)  
Conserved Domain (NCBI)H1-4
DMDM Disease mutations3008
Blocks (Seattle)H1-4
PDB (RSDB)3TZD    5JJZ    6H8P   
PDB Europe3TZD    5JJZ    6H8P   
PDB (PDBSum)3TZD    5JJZ    6H8P   
PDB (IMB)3TZD    5JJZ    6H8P   
Structural Biology KnowledgeBase3TZD    5JJZ    6H8P   
SCOP (Structural Classification of Proteins)3TZD    5JJZ    6H8P   
CATH (Classification of proteins structures)3TZD    5JJZ    6H8P   
SuperfamilyP10412
Human Protein Atlas [tissue]ENSG00000168298-H1-4 [tissue]
Peptide AtlasP10412
HPRD07513
IPIIPI00217467   
Protein Interaction databases
DIP (DOE-UCLA)P10412
IntAct (EBI)P10412
FunCoupENSG00000168298
BioGRIDH1-4
STRING (EMBL)H1-4
ZODIACH1-4
Ontologies - Pathways
QuickGOP10412
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  nuclear nucleosome  nuclear chromatin  double-stranded DNA binding  RNA binding  calcium ion binding  protein binding  ATP binding  GTP binding  nucleus  nucleus  nuclear euchromatin  nuclear heterochromatin  nucleosome assembly  regulation of transcription, DNA-templated  AMP binding  nucleosome positioning  chromosome condensation  chromatin DNA binding  nucleosomal DNA binding  negative regulation of chromatin silencing  dATP binding  ADP binding  negative regulation of DNA recombination  histone H3-K4 trimethylation  histone H3-K27 trimethylation  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  nuclear nucleosome  nuclear chromatin  double-stranded DNA binding  RNA binding  calcium ion binding  protein binding  ATP binding  GTP binding  nucleus  nucleus  nuclear euchromatin  nuclear heterochromatin  nucleosome assembly  regulation of transcription, DNA-templated  AMP binding  nucleosome positioning  chromosome condensation  chromatin DNA binding  nucleosomal DNA binding  negative regulation of chromatin silencing  dATP binding  ADP binding  negative regulation of DNA recombination  histone H3-K4 trimethylation  histone H3-K27 trimethylation  
NDEx NetworkH1-4
Atlas of Cancer Signalling NetworkH1-4
Wikipedia pathwaysH1-4
Orthology - Evolution
OrthoDB3008
GeneTree (enSembl)ENSG00000168298
Phylogenetic Trees/Animal Genes : TreeFamH1-4
HOGENOMP10412
Homologs : HomoloGeneH1-4
Homology/Alignments : Family Browser (UCSC)H1-4
Gene fusions - Rearrangements
Fusion : QuiverH1-4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerH1-4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)H1-4
dbVarH1-4
ClinVarH1-4
1000_GenomesH1-4 
Exome Variant ServerH1-4
ExAC (Exome Aggregation Consortium)ENSG00000168298
GNOMAD BrowserENSG00000168298
Varsome BrowserH1-4
Genetic variants : HAPMAP3008
Genomic Variants (DGV)H1-4 [DGVbeta]
DECIPHERH1-4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisH1-4 
Mutations
ICGC Data PortalH1-4 
TCGA Data PortalH1-4 
Broad Tumor PortalH1-4
OASIS PortalH1-4 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDH1-4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch H1-4
DgiDB (Drug Gene Interaction Database)H1-4
DoCM (Curated mutations)H1-4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)H1-4 (select a term)
intoGenH1-4
Cancer3DH1-4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142220    617537   
Orphanet
DisGeNETH1-4
MedgenH1-4
Genetic Testing Registry H1-4
NextProtP10412 [Medical]
TSGene3008
GENETestsH1-4
Target ValidationH1-4
Huge Navigator H1-4 [HugePedia]
snp3D : Map Gene to Disease3008
BioCentury BCIQH1-4
ClinGenH1-4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3008
Chemical/Pharm GKB GenePA29096
Clinical trialH1-4
Miscellaneous
canSAR (ICR)H1-4 (select the gene name)
HarmonizomeH1-4
DataMed IndexH1-4
Probes
Litterature
PubMed87 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineH1-4
EVEXH1-4
GoPubMedH1-4
iHOPH1-4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Wed Mar 11 19:09:43 CET 2020

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