H1-4 (H1.4 linker histone, cluster member)

2014-01-01  

Identity

HGNC
H1-4
LOCATION
6p22.2
LOCUSID
3008
ALIAS
H1.4,H1E,H1F4,H1s-4,HIST1H1E,RMNS,dJ221C16.5

Other Information

Locus ID:

NCBI: 3008
MIM: 142220
HGNC: 4718
Ensembl: ENSG00000168298

Variants:

dbSNP: 3008
ClinVar: 3008
TCGA: ENSG00000168298
COSMIC: H1-4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168298ENST00000304218P10412
ENSG00000168298ENST00000304218A3R0T8

Pathways

PathwaySourceExternal ID
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptosis induced DNA fragmentationREACTOMER-HSA-140342
Activation of DNA fragmentation factorREACTOMER-HSA-211227
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
DNA Damage/Telomere Stress Induced SenescenceREACTOMER-HSA-2559586
Formation of Senescence-Associated Heterochromatin Foci (SAHF)REACTOMER-HSA-2559584

References

Pubmed IDYearTitleCitations
191446452009Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.69
244350472014Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma.58
155957312004Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry.46
250480042015Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia.41
224659512012A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation.33
218522322011Protein kinase A-mediated serine 35 phosphorylation dissociates histone H1.4 from mitotic chromosome.13
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
262096082016Quantitative Mass Spectrometry Reveals that Intact Histone H1 Phosphorylations are Variant Specific and Exhibit Single Molecule Hierarchical Dependence.8
224259852012The N-terminal domain determines the affinity and specificity of H1 binding to chromatin.7
248738822014Dynamics and dispensability of variant-specific histone H1 Lys-26/Ser-27 and Thr-165 post-translational modifications.4

Citation

Dessen P

H1-4 (H1.4 linker histone, cluster member)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53757/h1-4