Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

H1-5 (H1.5 linker histone, cluster member)

Identity

Alias_namesH1F5
HIST1H1B
H1 histone family, member 5
histone 1, H1b
histone cluster 1, H1b
histone cluster 1 H1 family member b
Alias_symbol (synonym)H1b
H1s-3
Other aliasH1
H1.5
H1B
HGNC (Hugo) H1-5
LocusID (NCBI) 3009
Atlas_Id 53525
Location 6p22.1  [Link to chromosome band 6p22]
Location_base_pair Starts at 27866792 and ends at 27867581 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;7)(p22;p14) MPLKIP/HIST1H1B


External links

Nomenclature
HGNC (Hugo)H1-5   4719
Cards
Entrez_Gene (NCBI)H1-5  3009  H1.5 linker histone, cluster member
AliasesH1; H1.5; H1B; H1F5; 
H1s-3; HIST1H1B
GeneCards (Weizmann)H1-5
Ensembl hg19 (Hinxton)ENSG00000184357 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184357 [Gene_View]  ENSG00000184357 [Sequence]  chr6:27866792-27867581 [Contig_View]  H1-5 [Vega]
ICGC DataPortalENSG00000184357
TCGA cBioPortalH1-5
AceView (NCBI)H1-5
Genatlas (Paris)H1-5
WikiGenes3009
SOURCE (Princeton)H1-5
Genetics Home Reference (NIH)H1-5
Genomic and cartography
GoldenPath hg38 (UCSC)H1-5  -     chr6:27866792-27867581 -  -   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)H1-5  -     -   [Description]    (hg19-Feb_2009)
GoldenPathH1-5 - - [CytoView hg19]  H1-5 - - [CytoView hg38]
ImmunoBaseENSG00000184357
Mapping of homologs : NCBIH1-5 [Mapview hg19]  H1-5 [Mapview hg38]
OMIM142711   
Gene and transcription
Genbank (Entrez)BC069101 BC101581 BC101583
RefSeq transcript (Entrez)NM_005322
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)H1-5
Cluster EST : UnigeneHs.131956 [ NCBI ]
CGAP (NCI)Hs.131956
Alternative Splicing GalleryENSG00000184357
Gene ExpressionH1-5 [ NCBI-GEO ]   H1-5 [ EBI - ARRAY_EXPRESS ]   H1-5 [ SEEK ]   H1-5 [ MEM ]
Gene Expression Viewer (FireBrowse)H1-5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3009
GTEX Portal (Tissue expression)H1-5
Human Protein AtlasENSG00000184357-H1-5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16401   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP16401  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16401
Splice isoforms : SwissVarP16401
PhosPhoSitePlusP16401
Domaine pattern : Prosite (Expaxy)H15 (PS51504)   
Domains : Interpro (EBI)Histone_H1/H5_H15    Histone_H5    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)Linker_histone (PF00538)   
Domain families : Pfam (NCBI)pfam00538   
Domain families : Smart (EMBL)H15 (SM00526)  
Conserved Domain (NCBI)H1-5
DMDM Disease mutations3009
Blocks (Seattle)H1-5
PDB (RSDB)2FE2    2RHI   
PDB Europe2FE2    2RHI   
PDB (PDBSum)2FE2    2RHI   
PDB (IMB)2FE2    2RHI   
Structural Biology KnowledgeBase2FE2    2RHI   
SCOP (Structural Classification of Proteins)2FE2    2RHI   
CATH (Classification of proteins structures)2FE2    2RHI   
SuperfamilyP16401
Human Protein Atlas [tissue]ENSG00000184357-H1-5 [tissue]
Peptide AtlasP16401
HPRD00821
IPIIPI00217468   IPI00815867   
Protein Interaction databases
DIP (DOE-UCLA)P16401
IntAct (EBI)P16401
FunCoupENSG00000184357
BioGRIDH1-5
STRING (EMBL)H1-5
ZODIACH1-5
Ontologies - Pathways
QuickGOP16401
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  nucleosome  nuclear chromatin  nuclear chromatin  double-stranded DNA binding  RNA binding  protein binding  nucleus  nucleus  nuclear euchromatin  nuclear heterochromatin  chromatin organization  nucleosome assembly  regulation of transcription, DNA-templated  muscle organ development  nucleosome positioning  chromosome condensation  positive regulation of cell growth  chromatin DNA binding  nucleosomal DNA binding  negative regulation of chromatin silencing  histone deacetylase binding  negative regulation of DNA recombination  protein stabilization  positive regulation of histone H3-K9 methylation  establishment of protein localization to chromatin  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  nucleosome  nuclear chromatin  nuclear chromatin  double-stranded DNA binding  RNA binding  protein binding  nucleus  nucleus  nuclear euchromatin  nuclear heterochromatin  chromatin organization  nucleosome assembly  regulation of transcription, DNA-templated  muscle organ development  nucleosome positioning  chromosome condensation  positive regulation of cell growth  chromatin DNA binding  nucleosomal DNA binding  negative regulation of chromatin silencing  histone deacetylase binding  negative regulation of DNA recombination  protein stabilization  positive regulation of histone H3-K9 methylation  establishment of protein localization to chromatin  
NDEx NetworkH1-5
Atlas of Cancer Signalling NetworkH1-5
Wikipedia pathwaysH1-5
Orthology - Evolution
OrthoDB3009
GeneTree (enSembl)ENSG00000184357
Phylogenetic Trees/Animal Genes : TreeFamH1-5
HOGENOMP16401
Homologs : HomoloGeneH1-5
Homology/Alignments : Family Browser (UCSC)H1-5
Gene fusions - Rearrangements
Fusion : QuiverH1-5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerH1-5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)H1-5
dbVarH1-5
ClinVarH1-5
1000_GenomesH1-5 
Exome Variant ServerH1-5
ExAC (Exome Aggregation Consortium)ENSG00000184357
GNOMAD BrowserENSG00000184357
Varsome BrowserH1-5
Genetic variants : HAPMAP3009
Genomic Variants (DGV)H1-5 [DGVbeta]
DECIPHERH1-5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisH1-5 
Mutations
ICGC Data PortalH1-5 
TCGA Data PortalH1-5 
Broad Tumor PortalH1-5
OASIS PortalH1-5 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDH1-5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch H1-5
DgiDB (Drug Gene Interaction Database)H1-5
DoCM (Curated mutations)H1-5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)H1-5 (select a term)
intoGenH1-5
Cancer3DH1-5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142711   
Orphanet
DisGeNETH1-5
MedgenH1-5
Genetic Testing Registry H1-5
NextProtP16401 [Medical]
TSGene3009
GENETestsH1-5
Target ValidationH1-5
Huge Navigator H1-5 [HugePedia]
snp3D : Map Gene to Disease3009
BioCentury BCIQH1-5
ClinGenH1-5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3009
Chemical/Pharm GKB GenePA29097
Clinical trialH1-5
Miscellaneous
canSAR (ICR)H1-5 (select the gene name)
DataMed IndexH1-5
Probes
Litterature
PubMed109 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineH1-5
EVEXH1-5
GoPubMedH1-5
iHOPH1-5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:46:03 CET 2019

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.