H19 (H19 imprinted maternally expressed transcript)

2003-02-01  

Identity

HGNC
LOCATION
11p15.5
LOCUSID
ALIAS
ASM,ASM1,BWS,D11S813E,LINC00008,MIR675HG,NCRNA00008,WT2
FUSION GENES

Other Information

Locus ID:

NCBI: 283120
MIM: 103280
HGNC: 4713
Ensembl: ENSG00000130600

Variants:

dbSNP: 283120
ClinVar: 283120
TCGA: ENSG00000130600
COSMIC: H19

RNA/Proteins

Expression (GTEx)

0
50
100
150
200
250

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713176Platinum compoundsChemicalClinicalAnnotationassociatedPD26729200
PA444552HypertensionDiseaseLiterature, MultilinkAnnotationassociated24560520
PA444818Lung NeoplasmsDiseaseClinicalAnnotationassociatedPD26729200

References

Pubmed IDYearTitleCitations
124398232003Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19.161
199567662009Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus.158
83857451993Relaxation of imprinted genes in human cancer.149
249200702014H19 promotes pancreatic cancer metastasis by derepressing let-7's suppression on its target HMGA2-mediated EMT.111
249889462014lncRNA H19/miR-675 axis represses prostate cancer metastasis by targeting TGFBI.104
262726962015CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA.99
243889882014The long non-coding RNA H19-derived miR-675 modulates human gastric cancer cell proliferation by targeting tumor suppressor RUNX1.81
269890252016Long noncoding RNA H19 indicates a poor prognosis of colorectal cancer and promotes tumor growth by recruiting and binding to eIF4A3.75
118131342002Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects.70
263539302015H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b.68

Citation

Dessen P

H19 (H19 imprinted maternally expressed transcript)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/305/h19