H2AC20 (H2A clustered histone 20)

2021-06-01 Affiliation

Identity

HGNC

H2AC20

LOCATION

1q21.2

LOCUSID

8338

ALIAS

H2A,H2A-GL101,H2A/q,H2AFQ,HIST2H2AC

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8338
MIM: 602797
HGNC: 4738
Ensembl: ENSG00000184260

Variants:

dbSNP: 8338
ClinVar: 8338
TCGA: ENSG00000184260
COSMIC: H2AC20

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000184260	ENST00000331380	Q16777

Pathways

Pathway	Source	External ID
Systemic lupus erythematosus	KEGG	ko05322
Systemic lupus erythematosus	KEGG	hsa05322
Alcoholism	KEGG	hsa05034
Alcoholism	KEGG	ko05034
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Amyloid fiber formation	REACTOME	R-HSA-977225
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Rho GTPases	REACTOME	R-HSA-194315
RHO GTPase Effectors	REACTOME	R-HSA-195258
RHO GTPases activate PKNs	REACTOME	R-HSA-5625740
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	REACTOME	R-HSA-5625886
Signaling by Wnt	REACTOME	R-HSA-195721
TCF dependent signaling in response to WNT	REACTOME	R-HSA-201681
Formation of the beta-catenin:TCF transactivating complex	REACTOME	R-HSA-201722
Gene Expression	REACTOME	R-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	REACTOME	R-HSA-504046
RNA Polymerase I Transcription	REACTOME	R-HSA-73864
RNA Polymerase I Promoter Clearance	REACTOME	R-HSA-73854
RNA Polymerase I Promoter Opening	REACTOME	R-HSA-73728
RNA Polymerase I Chain Elongation	REACTOME	R-HSA-73777
Gene Silencing by RNA	REACTOME	R-HSA-211000
Transcriptional regulation by small RNAs	REACTOME	R-HSA-5578749
Epigenetic regulation of gene expression	REACTOME	R-HSA-212165
PRC2 methylates histones and DNA	REACTOME	R-HSA-212300
Negative epigenetic regulation of rRNA expression	REACTOME	R-HSA-5250941
SIRT1 negatively regulates rRNA Expression	REACTOME	R-HSA-427359
NoRC negatively regulates rRNA expression	REACTOME	R-HSA-427413
DNA methylation	REACTOME	R-HSA-5334118
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Prophase	REACTOME	R-HSA-68875
Condensation of Prophase Chromosomes	REACTOME	R-HSA-2299718
Chromosome Maintenance	REACTOME	R-HSA-73886
Nucleosome assembly	REACTOME	R-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromere	REACTOME	R-HSA-606279
Telomere Maintenance	REACTOME	R-HSA-157579
Packaging Of Telomere Ends	REACTOME	R-HSA-171306
Meiosis	REACTOME	R-HSA-1500620
Meiotic recombination	REACTOME	R-HSA-912446
Meiotic synapsis	REACTOME	R-HSA-1221632
Developmental Biology	REACTOME	R-HSA-1266738
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular Senescence	REACTOME	R-HSA-2559583
Oxidative Stress Induced Senescence	REACTOME	R-HSA-2559580
DNA Damage/Telomere Stress Induced Senescence	REACTOME	R-HSA-2559586
Senescence-Associated Secretory Phenotype (SASP)	REACTOME	R-HSA-2559582
Chromatin organization	REACTOME	R-HSA-4839726
Chromatin modifying enzymes	REACTOME	R-HSA-3247509
HATs acetylate histones	REACTOME	R-HSA-3214847
HDACs deacetylate histones	REACTOME	R-HSA-3214815
RMTs methylate histone arginines	REACTOME	R-HSA-3214858
Positive epigenetic regulation of rRNA expression	REACTOME	R-HSA-5250913
B-WICH complex positively regulates rRNA expression	REACTOME	R-HSA-5250924
Activation of HOX genes during differentiation	REACTOME	R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	REACTOME	R-HSA-5617472
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	REACTOME	R-HSA-427389
Deubiquitination	REACTOME	R-HSA-5688426
UCH proteinases	REACTOME	R-HSA-5689603
Ub-specific processing proteases	REACTOME	R-HSA-5689880
Metalloprotease DUBs	REACTOME	R-HSA-5689901

References

Pubmed ID	Year	Title	Citations
18206972	2008	A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.	157
16473935	2006	The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.	142
21633354	2011	Condensin association with histone H2A shapes mitotic chromosomes.	82
21596310	2011	L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure.	55
18593899	2008	The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A.	53
19500350	2009	RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX.	53
27791010	2016	Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial-mesenchymal transition.	43
19385636	2009	Acetylation of vertebrate H2A.Z and its effect on the structure of the nucleosome.	36
15823041	2005	Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes.	31
22334663	2012	Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase.	21

Citation

Dessen P

H2AC20 (H2A clustered histone 20)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58211/h2ac20