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H2AC4 (H2A clustered histone 4)

Identity

Alias (NCBI)H2A/m
H2AC8
H2AFM
HIST1H2AB
HGNC (Hugo) H2AC4
HGNC Alias symbH2A/m
HGNC Previous nameH2AFM
 HIST1H2AB
HGNC Previous nameH2A histone family, member M
 histone 1, H2ab
 histone cluster 1, H2ab
 histone cluster 1 H2A family member b
LocusID (NCBI) 8335
Atlas_Id 58137
Location 6p22.2  [Link to chromosome band 6p22]
Location_base_pair Starts at 26033092 and ends at 26033618 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)H2AC4   4734
Cards
Entrez_Gene (NCBI)H2AC4  8335  H2A clustered histone 4
AliasesH2A/m; H2AC8; H2AFM; HIST1H2AB
GeneCards (Weizmann)H2AC4
Ensembl hg19 (Hinxton)ENSG00000278463 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000278463 [Gene_View]  ENSG00000278463 [Sequence]  chr6:26033092-26033618 [Contig_View]  H2AC4 [Vega]
ICGC DataPortalENSG00000278463
TCGA cBioPortalH2AC4
AceView (NCBI)H2AC4
Genatlas (Paris)H2AC4
WikiGenes8335
SOURCE (Princeton)H2AC4
Genetics Home Reference (NIH)H2AC4
Genomic and cartography
GoldenPath hg38 (UCSC)H2AC4  -     chr6:26033092-26033618 -  -   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)H2AC4  -     -   [Description]    (hg19-Feb_2009)
GoldenPathH2AC4 - - [CytoView hg19]  H2AC4 - - [CytoView hg38]
ImmunoBaseENSG00000278463
genome Data Viewer NCBIH2AC4 [Mapview hg19]  
OMIM602795   
Gene and transcription
Genbank (Entrez)AK311785 BC125140
RefSeq transcript (Entrez)NM_003513
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)H2AC4
Alternative Splicing GalleryENSG00000278463
Gene ExpressionH2AC4 [ NCBI-GEO ]   H2AC4 [ EBI - ARRAY_EXPRESS ]   H2AC4 [ SEEK ]   H2AC4 [ MEM ]
Gene Expression Viewer (FireBrowse)H2AC4 [ Firebrowse - Broad ]
GenevisibleExpression of H2AC4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8335
GTEX Portal (Tissue expression)H2AC4
Human Protein AtlasENSG00000278463-H2AC4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04908   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP04908  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04908
Splice isoforms : SwissVarP04908
PhosPhoSitePlusP04908
Domaine pattern : Prosite (Expaxy)HISTONE_H2A (PS00046)   
Domains : Interpro (EBI)Histone-fold    Histone_H2A    Histone_H2A/H2B/H3    Histone_H2A_C    Histone_H2A_CS   
Domain families : Pfam (Sanger)Histone (PF00125)    Histone_H2A_C (PF16211)   
Domain families : Pfam (NCBI)pfam00125    pfam16211   
Domain families : Smart (EMBL)H2A (SM00414)  
Conserved Domain (NCBI)H2AC4
DMDM Disease mutations8335
Blocks (Seattle)H2AC4
PDB (RSDB)2CV5    2RVQ    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3W96    3W97    3W98    3W99    3WKJ    3WTP    3X1S    3X1V    4YM5    4YM6    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B40    5CPI    5CPJ    5CPK    5GSE    5GTC    5GXQ    5JRG    5X7X    5XF3    5XF4    5XF5    5Y0C    5Y0D    5Z23    5ZBX    6A5L    6A5O    6A5P    6A5R    6A5T    6A5U    6ACL    6AEE    6BUZ    6E0C    6E0P    6HKT    6HTS    6INQ    6IPU    6IQ4    6IR9    6J4W    6J4X    6J4Y    6J4Z    6J50    6J51    6JR0    6JR1    6JXD    6L49    6L4A    6O1D    6R8Y    6R8Z    6R90    6R91    6R92    6R93    6R94    6V92   
PDB Europe2CV5    2RVQ    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3W96    3W97    3W98    3W99    3WKJ    3WTP    3X1S    3X1V    4YM5    4YM6    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B40    5CPI    5CPJ    5CPK    5GSE    5GTC    5GXQ    5JRG    5X7X    5XF3    5XF4    5XF5    5Y0C    5Y0D    5Z23    5ZBX    6A5L    6A5O    6A5P    6A5R    6A5T    6A5U    6ACL    6AEE    6BUZ    6E0C    6E0P    6HKT    6HTS    6INQ    6IPU    6IQ4    6IR9    6J4W    6J4X    6J4Y    6J4Z    6J50    6J51    6JR0    6JR1    6JXD    6L49    6L4A    6O1D    6R8Y    6R8Z    6R90    6R91    6R92    6R93    6R94    6V92   
PDB (PDBSum)2CV5    2RVQ    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3W96    3W97    3W98    3W99    3WKJ    3WTP    3X1S    3X1V    4YM5    4YM6    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B40    5CPI    5CPJ    5CPK    5GSE    5GTC    5GXQ    5JRG    5X7X    5XF3    5XF4    5XF5    5Y0C    5Y0D    5Z23    5ZBX    6A5L    6A5O    6A5P    6A5R    6A5T    6A5U    6ACL    6AEE    6BUZ    6E0C    6E0P    6HKT    6HTS    6INQ    6IPU    6IQ4    6IR9    6J4W    6J4X    6J4Y    6J4Z    6J50    6J51    6JR0    6JR1    6JXD    6L49    6L4A    6O1D    6R8Y    6R8Z    6R90    6R91    6R92    6R93    6R94    6V92   
PDB (IMB)2CV5    2RVQ    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3W96    3W97    3W98    3W99    3WKJ    3WTP    3X1S    3X1V    4YM5    4YM6    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B40    5CPI    5CPJ    5CPK    5GSE    5GTC    5GXQ    5JRG    5X7X    5XF3    5XF4    5XF5    5Y0C    5Y0D    5Z23    5ZBX    6A5L    6A5O    6A5P    6A5R    6A5T    6A5U    6ACL    6AEE    6BUZ    6E0C    6E0P    6HKT    6HTS    6INQ    6IPU    6IQ4    6IR9    6J4W    6J4X    6J4Y    6J4Z    6J50    6J51    6JR0    6JR1    6JXD    6L49    6L4A    6O1D    6R8Y    6R8Z    6R90    6R91    6R92    6R93    6R94    6V92   
Structural Biology KnowledgeBase2CV5    2RVQ    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3W96    3W97    3W98    3W99    3WKJ    3WTP    3X1S    3X1V    4YM5    4YM6    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B40    5CPI    5CPJ    5CPK    5GSE    5GTC    5GXQ    5JRG    5X7X    5XF3    5XF4    5XF5    5Y0C    5Y0D    5Z23    5ZBX    6A5L    6A5O    6A5P    6A5R    6A5T    6A5U    6ACL    6AEE    6BUZ    6E0C    6E0P    6HKT    6HTS    6INQ    6IPU    6IQ4    6IR9    6J4W    6J4X    6J4Y    6J4Z    6J50    6J51    6JR0    6JR1    6JXD    6L49    6L4A    6O1D    6R8Y    6R8Z    6R90    6R91    6R92    6R93    6R94    6V92   
SCOP (Structural Classification of Proteins)2CV5    2RVQ    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3W96    3W97    3W98    3W99    3WKJ    3WTP    3X1S    3X1V    4YM5    4YM6    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B40    5CPI    5CPJ    5CPK    5GSE    5GTC    5GXQ    5JRG    5X7X    5XF3    5XF4    5XF5    5Y0C    5Y0D    5Z23    5ZBX    6A5L    6A5O    6A5P    6A5R    6A5T    6A5U    6ACL    6AEE    6BUZ    6E0C    6E0P    6HKT    6HTS    6INQ    6IPU    6IQ4    6IR9    6J4W    6J4X    6J4Y    6J4Z    6J50    6J51    6JR0    6JR1    6JXD    6L49    6L4A    6O1D    6R8Y    6R8Z    6R90    6R91    6R92    6R93    6R94    6V92   
CATH (Classification of proteins structures)2CV5    2RVQ    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3W96    3W97    3W98    3W99    3WKJ    3WTP    3X1S    3X1V    4YM5    4YM6    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B40    5CPI    5CPJ    5CPK    5GSE    5GTC    5GXQ    5JRG    5X7X    5XF3    5XF4    5XF5    5Y0C    5Y0D    5Z23    5ZBX    6A5L    6A5O    6A5P    6A5R    6A5T    6A5U    6ACL    6AEE    6BUZ    6E0C    6E0P    6HKT    6HTS    6INQ    6IPU    6IQ4    6IR9    6J4W    6J4X    6J4Y    6J4Z    6J50    6J51    6JR0    6JR1    6JXD    6L49    6L4A    6O1D    6R8Y    6R8Z    6R90    6R91    6R92    6R93    6R94    6V92   
SuperfamilyP04908
Human Protein Atlas [tissue]ENSG00000278463-H2AC4 [tissue]
Peptide AtlasP04908
Protein Interaction databases
DIP (DOE-UCLA)P04908
IntAct (EBI)P04908
FunCoupENSG00000278463
BioGRIDH2AC4
STRING (EMBL)H2AC4
ZODIACH2AC4
Ontologies - Pathways
QuickGOP04908
Ontology : AmiGOnucleosome  nuclear chromatin  DNA binding  DNA binding  protein binding  nucleus  nucleus  chromatin organization  chromatin silencing  negative regulation of cell proliferation  protein heterodimerization activity  extracellular exosome  
Ontology : EGO-EBInucleosome  nuclear chromatin  DNA binding  DNA binding  protein binding  nucleus  nucleus  chromatin organization  chromatin silencing  negative regulation of cell proliferation  protein heterodimerization activity  extracellular exosome  
NDEx NetworkH2AC4
Atlas of Cancer Signalling NetworkH2AC4
Wikipedia pathwaysH2AC4
Orthology - Evolution
OrthoDB8335
GeneTree (enSembl)ENSG00000278463
Phylogenetic Trees/Animal Genes : TreeFamH2AC4
HOGENOMP04908
Homologs : HomoloGeneH2AC4
Homology/Alignments : Family Browser (UCSC)H2AC4
Gene fusions - Rearrangements
Fusion : QuiverH2AC4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerH2AC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)H2AC4
dbVarH2AC4
ClinVarH2AC4
1000_GenomesH2AC4 
Exome Variant ServerH2AC4
GNOMAD BrowserENSG00000278463
Varsome BrowserH2AC4
Genetic variants : HAPMAP8335
Genomic Variants (DGV)H2AC4 [DGVbeta]
DECIPHERH2AC4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisH2AC4 
Mutations
ICGC Data PortalH2AC4 
TCGA Data PortalH2AC4 
Broad Tumor PortalH2AC4
OASIS PortalH2AC4 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDH2AC4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch H2AC4
DgiDB (Drug Gene Interaction Database)H2AC4
DoCM (Curated mutations)H2AC4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)H2AC4 (select a term)
intoGenH2AC4
Cancer3DH2AC4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602795   
Orphanet
DisGeNETH2AC4
MedgenH2AC4
Genetic Testing Registry H2AC4
NextProtP04908 [Medical]
TSGene8335
GENETestsH2AC4
Target ValidationH2AC4
Huge Navigator H2AC4 [HugePedia]
snp3D : Map Gene to Disease8335
BioCentury BCIQH2AC4
ClinGenH2AC4
Clinical trials, drugs, therapy
Protein Interactions : CTD8335
Clinical trialH2AC4
Miscellaneous
canSAR (ICR)H2AC4 (select the gene name)
HarmonizomeH2AC4
DataMed IndexH2AC4
Probes
Litterature
PubMed96 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineH2AC4
EVEXH2AC4
GoPubMedH2AC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 15:16:01 CEST 2020

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