Atlas of Genetics and Cytogenetics in Oncology and Haematology


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H2AFY2 (H2A histone family member Y2)

Identity

Alias_namesH2A histone family
Alias_symbol (synonym)macroH2A2
Other alias
HGNC (Hugo) H2AFY2
LocusID (NCBI) 55506
Atlas_Id 51204
Location 10q22.1  [Link to chromosome band 10q22]
Location_base_pair Starts at 71812357 and ends at 71872040 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CES1 (16q12.2) / H2AFY2 (10q22.1)H2AFY2 (10q22.1) / ANXA1 (9q21.13)H2AFY2 (10q22.1) / NDE1 (16p13.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)H2AFY2   14453
Cards
Entrez_Gene (NCBI)H2AFY2  55506  H2A histone family member Y2
AliasesmacroH2A2
GeneCards (Weizmann)H2AFY2
Ensembl hg19 (Hinxton)ENSG00000099284 [Gene_View]  chr10:71812357-71872040 [Contig_View]  H2AFY2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000099284 [Gene_View]  chr10:71812357-71872040 [Contig_View]  H2AFY2 [Vega]
ICGC DataPortalENSG00000099284
TCGA cBioPortalH2AFY2
AceView (NCBI)H2AFY2
Genatlas (Paris)H2AFY2
WikiGenes55506
SOURCE (Princeton)H2AFY2
Genetics Home Reference (NIH)H2AFY2
Genomic and cartography
GoldenPath hg19 (UCSC)H2AFY2  -     chr10:71812357-71872040 +  10q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)H2AFY2  -     10q22.1   [Description]    (hg38-Dec_2013)
EnsemblH2AFY2 - 10q22.1 [CytoView hg19]  H2AFY2 - 10q22.1 [CytoView hg38]
Mapping of homologs : NCBIH2AFY2 [Mapview hg19]  H2AFY2 [Mapview hg38]
OMIM616141   
Gene and transcription
Genbank (Entrez)AF151534 AF336304 AK022475 AK022776 AK131057
RefSeq transcript (Entrez)NM_018649
RefSeq genomic (Entrez)NC_000010 NC_018921 NT_030059 NW_004929376
Consensus coding sequences : CCDS (NCBI)H2AFY2
Cluster EST : UnigeneHs.499953 [ NCBI ]
CGAP (NCI)Hs.499953
Alternative Splicing GalleryENSG00000099284
Gene ExpressionH2AFY2 [ NCBI-GEO ]   H2AFY2 [ EBI - ARRAY_EXPRESS ]   H2AFY2 [ SEEK ]   H2AFY2 [ MEM ]
Gene Expression Viewer (FireBrowse)H2AFY2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55506
GTEX Portal (Tissue expression)H2AFY2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P0M6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P0M6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P0M6
Splice isoforms : SwissVarQ9P0M6
PhosPhoSitePlusQ9P0M6
Domaine pattern : Prosite (Expaxy)MACRO (PS51154)   
Domains : Interpro (EBI)Core_histone_macro-H2A    Histone-fold    Histone_H2A    Histone_H2A/H2B/H3    Histone_H2A_C    Macro_dom   
Domain families : Pfam (Sanger)Histone (PF00125)    Histone_H2A_C (PF16211)    Macro (PF01661)   
Domain families : Pfam (NCBI)pfam00125    pfam16211    pfam01661   
Domain families : Smart (EMBL)H2A (SM00414)  
Conserved Domain (NCBI)H2AFY2
DMDM Disease mutations55506
Blocks (Seattle)H2AFY2
PDB (SRS)2XD7   
PDB (PDBSum)2XD7   
PDB (IMB)2XD7   
PDB (RSDB)2XD7   
Structural Biology KnowledgeBase2XD7   
SCOP (Structural Classification of Proteins)2XD7   
CATH (Classification of proteins structures)2XD7   
SuperfamilyQ9P0M6
Human Protein AtlasENSG00000099284
Peptide AtlasQ9P0M6
HPRD13625
IPIIPI00220994   IPI00514864   IPI01014852   
Protein Interaction databases
DIP (DOE-UCLA)Q9P0M6
IntAct (EBI)Q9P0M6
FunCoupENSG00000099284
BioGRIDH2AFY2
STRING (EMBL)H2AFY2
ZODIACH2AFY2
Ontologies - Pathways
QuickGOQ9P0M6
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  nuclear chromosome, telomeric region  nucleosome  nuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  regulation of cell growth  Barr body  nucleoplasm  nucleosome assembly  chromatin silencing  brain development  dosage compensation  chromatin modification  chromatin DNA binding  ESC/E(Z) complex  transcription regulatory region DNA binding  positive regulation of keratinocyte differentiation  negative regulation of gene expression, epigenetic  protein heterodimerization activity  extracellular exosome  establishment of protein localization to chromatin  negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  nuclear chromosome, telomeric region  nucleosome  nuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  regulation of cell growth  Barr body  nucleoplasm  nucleosome assembly  chromatin silencing  brain development  dosage compensation  chromatin modification  chromatin DNA binding  ESC/E(Z) complex  transcription regulatory region DNA binding  positive regulation of keratinocyte differentiation  negative regulation of gene expression, epigenetic  protein heterodimerization activity  extracellular exosome  establishment of protein localization to chromatin  negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter  
Pathways : KEGGAlcoholism    Systemic lupus erythematosus   
NDEx NetworkH2AFY2
Atlas of Cancer Signalling NetworkH2AFY2
Wikipedia pathwaysH2AFY2
Orthology - Evolution
OrthoDB55506
GeneTree (enSembl)ENSG00000099284
Phylogenetic Trees/Animal Genes : TreeFamH2AFY2
HOVERGENQ9P0M6
HOGENOMQ9P0M6
Homologs : HomoloGeneH2AFY2
Homology/Alignments : Family Browser (UCSC)H2AFY2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerH2AFY2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)H2AFY2
dbVarH2AFY2
ClinVarH2AFY2
1000_GenomesH2AFY2 
Exome Variant ServerH2AFY2
ExAC (Exome Aggregation Consortium)H2AFY2 (select the gene name)
Genetic variants : HAPMAP55506
Genomic Variants (DGV)H2AFY2 [DGVbeta]
DECIPHER (Syndromes)10:71812357-71872040  ENSG00000099284
CONAN: Copy Number AnalysisH2AFY2 
Mutations
ICGC Data PortalH2AFY2 
TCGA Data PortalH2AFY2 
Broad Tumor PortalH2AFY2
OASIS PortalH2AFY2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICH2AFY2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDH2AFY2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch H2AFY2
DgiDB (Drug Gene Interaction Database)H2AFY2
DoCM (Curated mutations)H2AFY2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)H2AFY2 (select a term)
intoGenH2AFY2
Cancer3DH2AFY2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616141   
Orphanet
MedgenH2AFY2
Genetic Testing Registry H2AFY2
NextProtQ9P0M6 [Medical]
TSGene55506
GENETestsH2AFY2
Huge Navigator H2AFY2 [HugePedia]
snp3D : Map Gene to Disease55506
BioCentury BCIQH2AFY2
ClinGenH2AFY2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55506
Chemical/Pharm GKB GenePA29118
Clinical trialH2AFY2
Miscellaneous
canSAR (ICR)H2AFY2 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineH2AFY2
EVEXH2AFY2
GoPubMedH2AFY2
iHOPH2AFY2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:03:19 CEST 2017

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