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H2AFZ (H2A histone family member Z)

Identity

Alias_namesH2AZ
H2A histone family
Alias_symbol (synonym)H2A.Z
Other aliasH2A.Z-1
H2A.z
H2A/z
HGNC (Hugo) H2AFZ
LocusID (NCBI) 3015
Atlas_Id 40784
Location 4q23  [Link to chromosome band 4q23]
Location_base_pair Starts at 99948087 and ends at 99950355 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ERGIC3 (20q11.22) / H2AFZ (4q23)H2AFZ (4q23) / CD59 (11p13)H2AFZ (4q23) / CSDE1 (1p13.2)
H2AFZ (4q23) / RBPMS2 (15q22.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)H2AFZ   4741
Cards
Entrez_Gene (NCBI)H2AFZ  3015  H2A histone family member Z
AliasesH2A.Z-1; H2A.z; H2A/z; H2AZ
GeneCards (Weizmann)H2AFZ
Ensembl hg19 (Hinxton)ENSG00000164032 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164032 [Gene_View]  chr4:99948087-99950355 [Contig_View]  H2AFZ [Vega]
ICGC DataPortalENSG00000164032
TCGA cBioPortalH2AFZ
AceView (NCBI)H2AFZ
Genatlas (Paris)H2AFZ
WikiGenes3015
SOURCE (Princeton)H2AFZ
Genetics Home Reference (NIH)H2AFZ
Genomic and cartography
GoldenPath hg38 (UCSC)H2AFZ  -     chr4:99948087-99950355 -  4q23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)H2AFZ  -     4q23   [Description]    (hg19-Feb_2009)
EnsemblH2AFZ - 4q23 [CytoView hg19]  H2AFZ - 4q23 [CytoView hg38]
Mapping of homologs : NCBIH2AFZ [Mapview hg19]  H2AFZ [Mapview hg38]
OMIM142763   
Gene and transcription
Genbank (Entrez)AK056803 AK315413 AY597416 BC018002 BC020936
RefSeq transcript (Entrez)NM_002106
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)H2AFZ
Cluster EST : UnigeneHs.119192 [ NCBI ]
CGAP (NCI)Hs.119192
Alternative Splicing GalleryENSG00000164032
Gene ExpressionH2AFZ [ NCBI-GEO ]   H2AFZ [ EBI - ARRAY_EXPRESS ]   H2AFZ [ SEEK ]   H2AFZ [ MEM ]
Gene Expression Viewer (FireBrowse)H2AFZ [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3015
GTEX Portal (Tissue expression)H2AFZ
Protein : pattern, domain, 3D structure
UniProt/SwissProtP0C0S5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP0C0S5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP0C0S5
Splice isoforms : SwissVarP0C0S5
PhosPhoSitePlusP0C0S5
Domaine pattern : Prosite (Expaxy)HISTONE_H2A (PS00046)   
Domains : Interpro (EBI)Histone-fold    Histone_H2A    Histone_H2A/H2B/H3    Histone_H2A_C    Histone_H2A_CS   
Domain families : Pfam (Sanger)Histone (PF00125)    Histone_H2A_C (PF16211)   
Domain families : Pfam (NCBI)pfam00125    pfam16211   
Domain families : Smart (EMBL)H2A (SM00414)  
Conserved Domain (NCBI)H2AFZ
DMDM Disease mutations3015
Blocks (Seattle)H2AFZ
PDB (SRS)1F66    3WA9    4CAY    4NFT    5B31    5B32    5B33    5CHL    5FUG   
PDB (PDBSum)1F66    3WA9    4CAY    4NFT    5B31    5B32    5B33    5CHL    5FUG   
PDB (IMB)1F66    3WA9    4CAY    4NFT    5B31    5B32    5B33    5CHL    5FUG   
PDB (RSDB)1F66    3WA9    4CAY    4NFT    5B31    5B32    5B33    5CHL    5FUG   
Structural Biology KnowledgeBase1F66    3WA9    4CAY    4NFT    5B31    5B32    5B33    5CHL    5FUG   
SCOP (Structural Classification of Proteins)1F66    3WA9    4CAY    4NFT    5B31    5B32    5B33    5CHL    5FUG   
CATH (Classification of proteins structures)1F66    3WA9    4CAY    4NFT    5B31    5B32    5B33    5CHL    5FUG   
SuperfamilyP0C0S5
Human Protein AtlasENSG00000164032
Peptide AtlasP0C0S5
HPRD00823
IPIIPI00218448   
Protein Interaction databases
DIP (DOE-UCLA)P0C0S5
IntAct (EBI)P0C0S5
FunCoupENSG00000164032
BioGRIDH2AFZ
STRING (EMBL)H2AFZ
ZODIACH2AFZ
Ontologies - Pathways
QuickGOP0C0S5
Ontology : AmiGOnucleosome  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding  Barr body  protein binding  nucleus  nuclear euchromatin  nuclear heterochromatin  chromatin silencing  chromatin DNA binding  nucleosomal DNA binding  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  extracellular exosome  cellular response to estradiol stimulus  
Ontology : EGO-EBInucleosome  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding  Barr body  protein binding  nucleus  nuclear euchromatin  nuclear heterochromatin  chromatin silencing  chromatin DNA binding  nucleosomal DNA binding  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  extracellular exosome  cellular response to estradiol stimulus  
Pathways : KEGGAlcoholism    Systemic lupus erythematosus   
NDEx NetworkH2AFZ
Atlas of Cancer Signalling NetworkH2AFZ
Wikipedia pathwaysH2AFZ
Orthology - Evolution
OrthoDB3015
GeneTree (enSembl)ENSG00000164032
Phylogenetic Trees/Animal Genes : TreeFamH2AFZ
HOVERGENP0C0S5
HOGENOMP0C0S5
Homologs : HomoloGeneH2AFZ
Homology/Alignments : Family Browser (UCSC)H2AFZ
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerH2AFZ [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)H2AFZ
dbVarH2AFZ
ClinVarH2AFZ
1000_GenomesH2AFZ 
Exome Variant ServerH2AFZ
ExAC (Exome Aggregation Consortium)H2AFZ (select the gene name)
Genetic variants : HAPMAP3015
Genomic Variants (DGV)H2AFZ [DGVbeta]
DECIPHERH2AFZ [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisH2AFZ 
Mutations
ICGC Data PortalH2AFZ 
TCGA Data PortalH2AFZ 
Broad Tumor PortalH2AFZ
OASIS PortalH2AFZ [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICH2AFZ  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDH2AFZ
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch H2AFZ
DgiDB (Drug Gene Interaction Database)H2AFZ
DoCM (Curated mutations)H2AFZ (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)H2AFZ (select a term)
intoGenH2AFZ
Cancer3DH2AFZ(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142763   
Orphanet
MedgenH2AFZ
Genetic Testing Registry H2AFZ
NextProtP0C0S5 [Medical]
TSGene3015
GENETestsH2AFZ
Target ValidationH2AFZ
Huge Navigator H2AFZ [HugePedia]
snp3D : Map Gene to Disease3015
BioCentury BCIQH2AFZ
ClinGenH2AFZ
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3015
Chemical/Pharm GKB GenePA29119
Clinical trialH2AFZ
Miscellaneous
canSAR (ICR)H2AFZ (select the gene name)
Probes
Litterature
PubMed109 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineH2AFZ
EVEXH2AFZ
GoPubMedH2AFZ
iHOPH2AFZ
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:36:19 CEST 2017

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