Atlas of Genetics and Cytogenetics in Oncology and Haematology


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H2BC11 (H2B clustered histone 11)

Identity

Alias_namesH2BFR
HIST1H2BJ
H2B histone family, member R
histone 1, H2bj
histone cluster 1, H2bj
histone cluster 1 H2B family member j
Alias_symbol (synonym)H2B/r
Other aliasH2BJ
HGNC (Hugo) H2BC11
LocusID (NCBI) 8970
Atlas_Id 56917
Location 6p22.1  [Link to chromosome band 6p22]
Location_base_pair Starts at 27132316 and ends at 27132796 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(p21;p22) GTPBP2/HIST1H2BJ


External links

Nomenclature
HGNC (Hugo)H2BC11   4761
Cards
Entrez_Gene (NCBI)H2BC11  8970  H2B clustered histone 11
AliasesH2B/r; H2BFR; H2BJ; HIST1H2BJ
GeneCards (Weizmann)H2BC11
Ensembl hg19 (Hinxton)ENSG00000124635 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124635 [Gene_View]  ENSG00000124635 [Sequence]  chr6:27132316-27132796 [Contig_View]  H2BC11 [Vega]
ICGC DataPortalENSG00000124635
TCGA cBioPortalH2BC11
AceView (NCBI)H2BC11
Genatlas (Paris)H2BC11
WikiGenes8970
SOURCE (Princeton)H2BC11
Genetics Home Reference (NIH)H2BC11
Genomic and cartography
GoldenPath hg38 (UCSC)H2BC11  -     chr6:27132316-27132796 -  -   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)H2BC11  -     -   [Description]    (hg19-Feb_2009)
GoldenPathH2BC11 - - [CytoView hg19]  H2BC11 - - [CytoView hg38]
ImmunoBaseENSG00000124635
Mapping of homologs : NCBIH2BC11 [Mapview hg19]  H2BC11 [Mapview hg38]
OMIM615044   
Gene and transcription
Genbank (Entrez)AK311849 BC014312
RefSeq transcript (Entrez)NM_021058
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)H2BC11
Cluster EST : UnigeneHs.656567 [ NCBI ]
CGAP (NCI)Hs.656567
Alternative Splicing GalleryENSG00000124635
Gene ExpressionH2BC11 [ NCBI-GEO ]   H2BC11 [ EBI - ARRAY_EXPRESS ]   H2BC11 [ SEEK ]   H2BC11 [ MEM ]
Gene Expression Viewer (FireBrowse)H2BC11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8970
GTEX Portal (Tissue expression)H2BC11
Human Protein AtlasENSG00000124635-H2BC11 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP06899   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP06899  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP06899
Splice isoforms : SwissVarP06899
PhosPhoSitePlusP06899
Domaine pattern : Prosite (Expaxy)HISTONE_H2B (PS00357)   
Domains : Interpro (EBI)Histone-fold    Histone_H2A/H2B/H3    Histone_H2B   
Domain families : Pfam (Sanger)Histone (PF00125)   
Domain families : Pfam (NCBI)pfam00125   
Domain families : Smart (EMBL)H2B (SM00427)  
Conserved Domain (NCBI)H2BC11
DMDM Disease mutations8970
Blocks (Seattle)H2BC11
PDB (RSDB)2RVQ    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3W96    3W97    3W98    3W99    3WA9    3WAA    3WTP    4CAY    4YM5    4YM6    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B33    5B40    5CPI    5CPJ    5CPK    5FUG    5GSE    5GTC    5GXQ    5JRG    5VEY    5X7X    5XF3    5XF4    5XF5    6BUZ   
PDB Europe2RVQ    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3W96    3W97    3W98    3W99    3WA9    3WAA    3WTP    4CAY    4YM5    4YM6    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B33    5B40    5CPI    5CPJ    5CPK    5FUG    5GSE    5GTC    5GXQ    5JRG    5VEY    5X7X    5XF3    5XF4    5XF5    6BUZ   
PDB (PDBSum)2RVQ    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3W96    3W97    3W98    3W99    3WA9    3WAA    3WTP    4CAY    4YM5    4YM6    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B33    5B40    5CPI    5CPJ    5CPK    5FUG    5GSE    5GTC    5GXQ    5JRG    5VEY    5X7X    5XF3    5XF4    5XF5    6BUZ   
PDB (IMB)2RVQ    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3W96    3W97    3W98    3W99    3WA9    3WAA    3WTP    4CAY    4YM5    4YM6    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B33    5B40    5CPI    5CPJ    5CPK    5FUG    5GSE    5GTC    5GXQ    5JRG    5VEY    5X7X    5XF3    5XF4    5XF5    6BUZ   
Structural Biology KnowledgeBase2RVQ    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3W96    3W97    3W98    3W99    3WA9    3WAA    3WTP    4CAY    4YM5    4YM6    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B33    5B40    5CPI    5CPJ    5CPK    5FUG    5GSE    5GTC    5GXQ    5JRG    5VEY    5X7X    5XF3    5XF4    5XF5    6BUZ   
SCOP (Structural Classification of Proteins)2RVQ    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3W96    3W97    3W98    3W99    3WA9    3WAA    3WTP    4CAY    4YM5    4YM6    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B33    5B40    5CPI    5CPJ    5CPK    5FUG    5GSE    5GTC    5GXQ    5JRG    5VEY    5X7X    5XF3    5XF4    5XF5    6BUZ   
CATH (Classification of proteins structures)2RVQ    3A6N    3AFA    3AN2    3AV1    3AV2    3AYW    3AZE    3AZF    3AZG    3AZH    3AZI    3AZJ    3AZK    3AZL    3AZM    3AZN    3W96    3W97    3W98    3W99    3WA9    3WAA    3WTP    4CAY    4YM5    4YM6    4Z5T    5AV5    5AV6    5AV8    5AV9    5AVB    5AVC    5AY8    5B0Y    5B0Z    5B24    5B2I    5B2J    5B31    5B32    5B33    5B40    5CPI    5CPJ    5CPK    5FUG    5GSE    5GTC    5GXQ    5JRG    5VEY    5X7X    5XF3    5XF4    5XF5    6BUZ   
SuperfamilyP06899
Human Protein Atlas [tissue]ENSG00000124635-H2BC11 [tissue]
Peptide AtlasP06899
IPIIPI00515061   
Protein Interaction databases
DIP (DOE-UCLA)P06899
IntAct (EBI)P06899
FunCoupENSG00000124635
BioGRIDH2BC11
STRING (EMBL)H2BC11
ZODIACH2BC11
Ontologies - Pathways
QuickGOP06899
Ontology : AmiGOnucleosome  lipopolysaccharide binding  innate immune response in mucosa  DNA binding  DNA binding  protein binding  extracellular space  nucleus  nucleus  nucleoplasm  nucleoplasm  cytosol  plasma membrane  nucleosome assembly  nucleosome assembly  negative regulation of tumor necrosis factor-mediated signaling pathway  protein ubiquitination  antibacterial humoral response  killing of cells of other organism  protein heterodimerization activity  defense response to Gram-negative bacterium  defense response to Gram-positive bacterium  antimicrobial humoral immune response mediated by antimicrobial peptide  
Ontology : EGO-EBInucleosome  lipopolysaccharide binding  innate immune response in mucosa  DNA binding  DNA binding  protein binding  extracellular space  nucleus  nucleus  nucleoplasm  nucleoplasm  cytosol  plasma membrane  nucleosome assembly  nucleosome assembly  negative regulation of tumor necrosis factor-mediated signaling pathway  protein ubiquitination  antibacterial humoral response  killing of cells of other organism  protein heterodimerization activity  defense response to Gram-negative bacterium  defense response to Gram-positive bacterium  antimicrobial humoral immune response mediated by antimicrobial peptide  
NDEx NetworkH2BC11
Atlas of Cancer Signalling NetworkH2BC11
Wikipedia pathwaysH2BC11
Orthology - Evolution
OrthoDB8970
GeneTree (enSembl)ENSG00000124635
Phylogenetic Trees/Animal Genes : TreeFamH2BC11
HOGENOMP06899
Homologs : HomoloGeneH2BC11
Homology/Alignments : Family Browser (UCSC)H2BC11
Gene fusions - Rearrangements
Fusion : QuiverH2BC11
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerH2BC11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)H2BC11
dbVarH2BC11
ClinVarH2BC11
1000_GenomesH2BC11 
Exome Variant ServerH2BC11
ExAC (Exome Aggregation Consortium)ENSG00000124635
GNOMAD BrowserENSG00000124635
Varsome BrowserH2BC11
Genetic variants : HAPMAP8970
Genomic Variants (DGV)H2BC11 [DGVbeta]
DECIPHERH2BC11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisH2BC11 
Mutations
ICGC Data PortalH2BC11 
TCGA Data PortalH2BC11 
Broad Tumor PortalH2BC11
OASIS PortalH2BC11 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDH2BC11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch H2BC11
DgiDB (Drug Gene Interaction Database)H2BC11
DoCM (Curated mutations)H2BC11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)H2BC11 (select a term)
intoGenH2BC11
Cancer3DH2BC11(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615044   
Orphanet
DisGeNETH2BC11
MedgenH2BC11
Genetic Testing Registry H2BC11
NextProtP06899 [Medical]
TSGene8970
GENETestsH2BC11
Target ValidationH2BC11
Huge Navigator H2BC11 [HugePedia]
snp3D : Map Gene to Disease8970
BioCentury BCIQH2BC11
ClinGenH2BC11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8970
Chemical/Pharm GKB GenePA29136
Clinical trialH2BC11
Miscellaneous
canSAR (ICR)H2BC11 (select the gene name)
DataMed IndexH2BC11
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineH2BC11
EVEXH2BC11
GoPubMedH2BC11
iHOPH2BC11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:46:06 CET 2019

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