Atlas of Genetics and Cytogenetics in Oncology and Haematology


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H3-3A (H3.3 histone A)

Identity

Alias_namesH3F3
H3F3A
H3 histone, family 3A
H3 histone family member 3A
Alias_symbol (synonym)H3.3A
Other alias
HGNC (Hugo) H3-3A
LocusID (NCBI) 3020
Atlas_Id 53228
Location 1q42.12  [Link to chromosome band 1q42]
Location_base_pair Starts at 226062707 and ends at 226072002 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)H3-3A   4764
Cards
Entrez_Gene (NCBI)H3-3A  3020  H3.3 histone A
AliasesH3.3A; H3F3; H3F3A
GeneCards (Weizmann)H3-3A
Ensembl hg19 (Hinxton)ENSG00000163041 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163041 [Gene_View]  ENSG00000163041 [Sequence]  chr1:226062707-226072002 [Contig_View]  H3-3A [Vega]
ICGC DataPortalENSG00000163041
TCGA cBioPortalH3-3A
AceView (NCBI)H3-3A
Genatlas (Paris)H3-3A
WikiGenes3020
SOURCE (Princeton)H3-3A
Genetics Home Reference (NIH)H3-3A
Genomic and cartography
GoldenPath hg38 (UCSC)H3-3A  -     chr1:226062707-226072002 +  -   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)H3-3A  -     -   [Description]    (hg19-Feb_2009)
GoldenPathH3-3A - - [CytoView hg19]  H3-3A - - [CytoView hg38]
ImmunoBaseENSG00000163041
Mapping of homologs : NCBIH3-3A [Mapview hg19]  H3-3A [Mapview hg38]
OMIM601128   
Gene and transcription
Genbank (Entrez)AK293541 AK311905 BC013857 BC029405 BC038989
RefSeq transcript (Entrez)NM_002107
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)H3-3A
Cluster EST : UnigeneHs.726012 [ NCBI ]
CGAP (NCI)Hs.726012
Alternative Splicing GalleryENSG00000163041
Gene ExpressionH3-3A [ NCBI-GEO ]   H3-3A [ EBI - ARRAY_EXPRESS ]   H3-3A [ SEEK ]   H3-3A [ MEM ]
Gene Expression Viewer (FireBrowse)H3-3A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3020
GTEX Portal (Tissue expression)H3-3A
Human Protein AtlasENSG00000163041-H3-3A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP84243   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP84243  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP84243
Splice isoforms : SwissVarP84243
PhosPhoSitePlusP84243
Domaine pattern : Prosite (Expaxy)HISTONE_H3_1 (PS00322)    HISTONE_H3_2 (PS00959)   
Domains : Interpro (EBI)Histone-fold    Histone_H2A/H2B/H3    Histone_H3/CENP-A   
Domain families : Pfam (Sanger)Histone (PF00125)   
Domain families : Pfam (NCBI)pfam00125   
Domain families : Smart (EMBL)H3 (SM00428)  
Conserved Domain (NCBI)H3-3A
DMDM Disease mutations3020
Blocks (Seattle)H3-3A
PDB (RSDB)2L43    3ASK    3ASL    3AV2    3JVK    3MUK    3MUL    3QL9    3QLA    3QLC    3WTP    4GNE    4GNF    4GNG    4GU0    4GUR    4GUS    4GY5    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA    4L58    4N4I    4O62    4QQ4    4TMP    4U7T    4W5A    5AY8    5B32    5B33    5BNV    5BNX    5DWQ    5DX0    5JA4    5JJY    5JLB    5KDM    5X7X   
PDB Europe2L43    3ASK    3ASL    3AV2    3JVK    3MUK    3MUL    3QL9    3QLA    3QLC    3WTP    4GNE    4GNF    4GNG    4GU0    4GUR    4GUS    4GY5    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA    4L58    4N4I    4O62    4QQ4    4TMP    4U7T    4W5A    5AY8    5B32    5B33    5BNV    5BNX    5DWQ    5DX0    5JA4    5JJY    5JLB    5KDM    5X7X   
PDB (PDBSum)2L43    3ASK    3ASL    3AV2    3JVK    3MUK    3MUL    3QL9    3QLA    3QLC    3WTP    4GNE    4GNF    4GNG    4GU0    4GUR    4GUS    4GY5    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA    4L58    4N4I    4O62    4QQ4    4TMP    4U7T    4W5A    5AY8    5B32    5B33    5BNV    5BNX    5DWQ    5DX0    5JA4    5JJY    5JLB    5KDM    5X7X   
PDB (IMB)2L43    3ASK    3ASL    3AV2    3JVK    3MUK    3MUL    3QL9    3QLA    3QLC    3WTP    4GNE    4GNF    4GNG    4GU0    4GUR    4GUS    4GY5    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA    4L58    4N4I    4O62    4QQ4    4TMP    4U7T    4W5A    5AY8    5B32    5B33    5BNV    5BNX    5DWQ    5DX0    5JA4    5JJY    5JLB    5KDM    5X7X   
Structural Biology KnowledgeBase2L43    3ASK    3ASL    3AV2    3JVK    3MUK    3MUL    3QL9    3QLA    3QLC    3WTP    4GNE    4GNF    4GNG    4GU0    4GUR    4GUS    4GY5    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA    4L58    4N4I    4O62    4QQ4    4TMP    4U7T    4W5A    5AY8    5B32    5B33    5BNV    5BNX    5DWQ    5DX0    5JA4    5JJY    5JLB    5KDM    5X7X   
SCOP (Structural Classification of Proteins)2L43    3ASK    3ASL    3AV2    3JVK    3MUK    3MUL    3QL9    3QLA    3QLC    3WTP    4GNE    4GNF    4GNG    4GU0    4GUR    4GUS    4GY5    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA    4L58    4N4I    4O62    4QQ4    4TMP    4U7T    4W5A    5AY8    5B32    5B33    5BNV    5BNX    5DWQ    5DX0    5JA4    5JJY    5JLB    5KDM    5X7X   
CATH (Classification of proteins structures)2L43    3ASK    3ASL    3AV2    3JVK    3MUK    3MUL    3QL9    3QLA    3QLC    3WTP    4GNE    4GNF    4GNG    4GU0    4GUR    4GUS    4GY5    4H9N    4H9O    4H9P    4H9Q    4H9R    4H9S    4HGA    4L58    4N4I    4O62    4QQ4    4TMP    4U7T    4W5A    5AY8    5B32    5B33    5BNV    5BNX    5DWQ    5DX0    5JA4    5JJY    5JLB    5KDM    5X7X   
SuperfamilyP84243
Human Protein Atlas [tissue]ENSG00000163041-H3-3A [tissue]
Peptide AtlasP84243
HPRD03082
IPIIPI00219038   IPI00909530   IPI00477080   
Protein Interaction databases
DIP (DOE-UCLA)P84243
IntAct (EBI)P84243
FunCoupENSG00000163041
BioGRIDH3-3A
STRING (EMBL)H3-3A
ZODIACH3-3A
Ontologies - Pathways
QuickGOP84243
Ontology : AmiGOchromatin silencing at rDNA  nuclear chromosome  nuclear chromosome, telomeric region  nucleosome  nucleosome  nuclear nucleosome  RNA polymerase II core promoter sequence-specific DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding  osteoblast differentiation  Barr body  protein binding  extracellular region  nucleus  nucleus  nucleus  nucleoplasm  nucleosome assembly  nucleosome assembly  DNA replication-independent nucleosome assembly  nucleus organization  spermatid development  single fertilization  brain development  embryo implantation  blood coagulation  cell proliferation  male gonad development  response to hormone  positive regulation of cell growth  nucleosomal DNA binding  nucleosomal DNA binding  pericentric heterochromatin assembly  telomeric heterochromatin assembly  telomere organization  protein-containing complex  multicellular organism growth  muscle cell differentiation  cellular protein metabolic process  regulation of megakaryocyte differentiation  negative regulation of gene expression, epigenetic  protein heterodimerization activity  oogenesis  regulation of gene silencing by miRNA  extracellular exosome  regulation of centromere complex assembly  negative regulation of chromosome condensation  
Ontology : EGO-EBIchromatin silencing at rDNA  nuclear chromosome  nuclear chromosome, telomeric region  nucleosome  nucleosome  nuclear nucleosome  RNA polymerase II core promoter sequence-specific DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding  osteoblast differentiation  Barr body  protein binding  extracellular region  nucleus  nucleus  nucleus  nucleoplasm  nucleosome assembly  nucleosome assembly  DNA replication-independent nucleosome assembly  nucleus organization  spermatid development  single fertilization  brain development  embryo implantation  blood coagulation  cell proliferation  male gonad development  response to hormone  positive regulation of cell growth  nucleosomal DNA binding  nucleosomal DNA binding  pericentric heterochromatin assembly  telomeric heterochromatin assembly  telomere organization  protein-containing complex  multicellular organism growth  muscle cell differentiation  cellular protein metabolic process  regulation of megakaryocyte differentiation  negative regulation of gene expression, epigenetic  protein heterodimerization activity  oogenesis  regulation of gene silencing by miRNA  extracellular exosome  regulation of centromere complex assembly  negative regulation of chromosome condensation  
NDEx NetworkH3-3A
Atlas of Cancer Signalling NetworkH3-3A
Wikipedia pathwaysH3-3A
Orthology - Evolution
OrthoDB3020
GeneTree (enSembl)ENSG00000163041
Phylogenetic Trees/Animal Genes : TreeFamH3-3A
HOGENOMP84243
Homologs : HomoloGeneH3-3A
Homology/Alignments : Family Browser (UCSC)H3-3A
Gene fusions - Rearrangements
Fusion : QuiverH3-3A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerH3-3A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)H3-3A
dbVarH3-3A
ClinVarH3-3A
1000_GenomesH3-3A 
Exome Variant ServerH3-3A
ExAC (Exome Aggregation Consortium)ENSG00000163041
GNOMAD BrowserENSG00000163041
Varsome BrowserH3-3A
Genetic variants : HAPMAP3020
Genomic Variants (DGV)H3-3A [DGVbeta]
DECIPHERH3-3A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisH3-3A 
Mutations
ICGC Data PortalH3-3A 
TCGA Data PortalH3-3A 
Broad Tumor PortalH3-3A
OASIS PortalH3-3A [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDH3-3A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch H3-3A
DgiDB (Drug Gene Interaction Database)H3-3A
DoCM (Curated mutations)H3-3A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)H3-3A (select a term)
intoGenH3-3A
Cancer3DH3-3A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601128   
Orphanet
DisGeNETH3-3A
MedgenH3-3A
Genetic Testing Registry H3-3A
NextProtP84243 [Medical]
TSGene3020
GENETestsH3-3A
Target ValidationH3-3A
Huge Navigator H3-3A [HugePedia]
snp3D : Map Gene to Disease3020
BioCentury BCIQH3-3A
ClinGenH3-3A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3020
Chemical/Pharm GKB GenePA29139
Clinical trialH3-3A
Miscellaneous
canSAR (ICR)H3-3A (select the gene name)
DataMed IndexH3-3A
Probes
Litterature
PubMed172 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineH3-3A
EVEXH3-3A
GoPubMedH3-3A
iHOPH3-3A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:46:07 CET 2019

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