Atlas of Genetics and Cytogenetics in Oncology and Haematology

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HACD1 (3-hydroxyacyl-CoA dehydratase 1)

Identity

Alias_namesPTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
Alias_symbol (synonym)CAP
Other alias
HGNC (Hugo) HACD1
LocusID (NCBI) 9200
Atlas_Id 46754
Location 9q22.32  [Link to chromosome band 9q22]
Location_base_pair Starts at 17589959 and ends at 17617374 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)HACD1   9639
Cards
Entrez_Gene (NCBI)HACD1  9200  3-hydroxyacyl-CoA dehydratase 1
AliasesCAP; PTPLA
GeneCards (Weizmann)HACD1
Ensembl hg19 (Hinxton)ENSG00000165996 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165996 [Gene_View]  ENSG00000165996 [Sequence]  chr10:17589959-17617374 [Contig_View]  HACD1 [Vega]
ICGC DataPortalENSG00000165996
TCGA cBioPortalHACD1
AceView (NCBI)HACD1
Genatlas (Paris)HACD1
WikiGenes9200
SOURCE (Princeton)HACD1
Genetics Home Reference (NIH)HACD1
Genomic and cartography
GoldenPath hg38 (UCSC)HACD1  -     chr10:17589959-17617374 -  9q22.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HACD1  -     9q22.32   [Description]    (hg19-Feb_2009)
EnsemblHACD1 - 9q22.32 [CytoView hg19]  HACD1 - 9q22.32 [CytoView hg38]
Mapping of homologs : NCBIHACD1 [Mapview hg19]  HACD1 [Mapview hg38]
OMIM610467   
Gene and transcription
Genbank (Entrez)AF114494 AW022173 AY455942 BC010353 BC027709
RefSeq transcript (Entrez)NM_014241
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HACD1
Cluster EST : UnigeneHs.114062 [ NCBI ]
CGAP (NCI)Hs.114062
Alternative Splicing GalleryENSG00000165996
Gene ExpressionHACD1 [ NCBI-GEO ]   HACD1 [ EBI - ARRAY_EXPRESS ]   HACD1 [ SEEK ]   HACD1 [ MEM ]
Gene Expression Viewer (FireBrowse)HACD1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9200
GTEX Portal (Tissue expression)HACD1
Human Protein AtlasENSG00000165996-HACD1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtB0YJ81   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtB0YJ81  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProB0YJ81
Splice isoforms : SwissVarB0YJ81
PhosPhoSitePlusB0YJ81
Domains : Interpro (EBI)Tyr_Pase-like_PTPLA   
Domain families : Pfam (Sanger)PTPLA (PF04387)   
Domain families : Pfam (NCBI)pfam04387   
Conserved Domain (NCBI)HACD1
DMDM Disease mutations9200
Blocks (Seattle)HACD1
SuperfamilyB0YJ81
Human Protein Atlas [tissue]ENSG00000165996-HACD1 [tissue]
Peptide AtlasB0YJ81
HPRD10175
IPIIPI00307235   IPI00426084   IPI00295804   
Protein Interaction databases
DIP (DOE-UCLA)B0YJ81
IntAct (EBI)B0YJ81
FunCoupENSG00000165996
BioGRIDHACD1
STRING (EMBL)HACD1
ZODIACHACD1
Ontologies - Pathways
QuickGOB0YJ81
Ontology : AmiGOendoplasmic reticulum membrane  multicellular organism development  3-hydroxyacyl-CoA dehydratase activity  sphingolipid biosynthetic process  integral component of endoplasmic reticulum membrane  fatty acid elongation  long-chain fatty-acyl-CoA biosynthetic process  very long-chain fatty acid biosynthetic process  3R-hydroxyacyl-CoA dehydratase activity  very-long-chain 3-hydroxyacyl-CoA dehydratase activity  3-hydroxy-arachidoyl-CoA dehydratase activity  3-hydroxy-behenoyl-CoA dehydratase activity  3-hydroxy-lignoceroyl-CoA dehydratase activity  
Ontology : EGO-EBIendoplasmic reticulum membrane  multicellular organism development  3-hydroxyacyl-CoA dehydratase activity  sphingolipid biosynthetic process  integral component of endoplasmic reticulum membrane  fatty acid elongation  long-chain fatty-acyl-CoA biosynthetic process  very long-chain fatty acid biosynthetic process  3R-hydroxyacyl-CoA dehydratase activity  very-long-chain 3-hydroxyacyl-CoA dehydratase activity  3-hydroxy-arachidoyl-CoA dehydratase activity  3-hydroxy-behenoyl-CoA dehydratase activity  3-hydroxy-lignoceroyl-CoA dehydratase activity  
NDEx NetworkHACD1
Atlas of Cancer Signalling NetworkHACD1
Wikipedia pathwaysHACD1
Orthology - Evolution
OrthoDB9200
GeneTree (enSembl)ENSG00000165996
Phylogenetic Trees/Animal Genes : TreeFamHACD1
HOVERGENB0YJ81
HOGENOMB0YJ81
Homologs : HomoloGeneHACD1
Homology/Alignments : Family Browser (UCSC)HACD1
Gene fusions - Rearrangements
Fusion : QuiverHACD1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHACD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HACD1
dbVarHACD1
ClinVarHACD1
1000_GenomesHACD1 
Exome Variant ServerHACD1
ExAC (Exome Aggregation Consortium)ENSG00000165996
GNOMAD BrowserENSG00000165996
Varsome BrowserHACD1
Genetic variants : HAPMAP9200
Genomic Variants (DGV)HACD1 [DGVbeta]
DECIPHERHACD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHACD1 
Mutations
ICGC Data PortalHACD1 
TCGA Data PortalHACD1 
Broad Tumor PortalHACD1
OASIS PortalHACD1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDHACD1
BioMutasearch HACD1
DgiDB (Drug Gene Interaction Database)HACD1
DoCM (Curated mutations)HACD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HACD1 (select a term)
intoGenHACD1
Cancer3DHACD1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610467   
Orphanet493   
DisGeNETHACD1
MedgenHACD1
Genetic Testing Registry HACD1
NextProtB0YJ81 [Medical]
TSGene9200
GENETestsHACD1
Target ValidationHACD1
Huge Navigator HACD1 [HugePedia]
snp3D : Map Gene to Disease9200
BioCentury BCIQHACD1
ClinGenHACD1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9200
Chemical/Pharm GKB GenePA33982
Clinical trialHACD1
Miscellaneous
canSAR (ICR)HACD1 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHACD1
EVEXHACD1
GoPubMedHACD1
iHOPHACD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Aug 16 11:05:21 CEST 2018
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