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HACD2 (3-hydroxyacyl-CoA dehydratase 2)

Identity

Alias_namesPTPLB
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b
Other alias
HGNC (Hugo) HACD2
LocusID (NCBI) 201562
Atlas_Id 77046
Location 3q21.1  [Link to chromosome band 3q21]
Location_base_pair Starts at 123491548 and ends at 123585185 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADCY5 (3q21.1) / HACD2 (3q21.1)HACD2 (3q21.1) / HIP1 (7q11.23)HACD2 (3q21.1) / RSRC1 (3q25.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HACD2   9640
Cards
Entrez_Gene (NCBI)HACD2  201562  3-hydroxyacyl-CoA dehydratase 2
AliasesPTPLB
GeneCards (Weizmann)HACD2
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr3:123491548-123585185 [Contig_View]  HACD2 [Vega]
TCGA cBioPortalHACD2
AceView (NCBI)HACD2
Genatlas (Paris)HACD2
WikiGenes201562
SOURCE (Princeton)HACD2
Genetics Home Reference (NIH)HACD2
Genomic and cartography
GoldenPath hg38 (UCSC)HACD2  -     chr3:123491548-123585185 -  3q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HACD2  -     3q21.1   [Description]    (hg19-Feb_2009)
EnsemblHACD2 - 3q21.1 [CytoView hg19]  HACD2 - 3q21.1 [CytoView hg38]
Mapping of homologs : NCBIHACD2 [Mapview hg19]  HACD2 [Mapview hg38]
OMIM615939   
Gene and transcription
Genbank (Entrez)AA836691 AF052159 AK074605 AK289983 AL832532
RefSeq transcript (Entrez)NM_001329783 NM_001329784 NM_001329786 NM_001329787 NM_198402
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HACD2
Cluster EST : UnigeneHs.705480 [ NCBI ]
CGAP (NCI)Hs.705480
Gene ExpressionHACD2 [ NCBI-GEO ]   HACD2 [ EBI - ARRAY_EXPRESS ]   HACD2 [ SEEK ]   HACD2 [ MEM ]
Gene Expression Viewer (FireBrowse)HACD2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)201562
GTEX Portal (Tissue expression)HACD2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6Y1H2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6Y1H2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6Y1H2
Splice isoforms : SwissVarQ6Y1H2
PhosPhoSitePlusQ6Y1H2
Domains : Interpro (EBI)Tyr_Pase-like_PTPLA   
Domain families : Pfam (Sanger)PTPLA (PF04387)   
Domain families : Pfam (NCBI)pfam04387   
Conserved Domain (NCBI)HACD2
DMDM Disease mutations201562
Blocks (Seattle)HACD2
SuperfamilyQ6Y1H2
Peptide AtlasQ6Y1H2
HPRD17930
IPIIPI00384497   IPI00947066   IPI00946896   
Protein Interaction databases
DIP (DOE-UCLA)Q6Y1H2
IntAct (EBI)Q6Y1H2
BioGRIDHACD2
STRING (EMBL)HACD2
ZODIACHACD2
Ontologies - Pathways
QuickGOQ6Y1H2
Ontology : AmiGOprotein tyrosine phosphatase activity  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  integral component of membrane  3-hydroxyacyl-CoA dehydratase activity  enzyme binding  sphingolipid biosynthetic process  fatty acid elongation  long-chain fatty-acyl-CoA biosynthetic process  very long-chain fatty acid biosynthetic process  3R-hydroxyacyl-CoA dehydratase activity  3-hydroxy-arachidoyl-CoA dehydratase activity  3-hydroxy-behenoyl-CoA dehydratase activity  3-hydroxy-lignoceroyl-CoA dehydratase activity  
Ontology : EGO-EBIprotein tyrosine phosphatase activity  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  integral component of membrane  3-hydroxyacyl-CoA dehydratase activity  enzyme binding  sphingolipid biosynthetic process  fatty acid elongation  long-chain fatty-acyl-CoA biosynthetic process  very long-chain fatty acid biosynthetic process  3R-hydroxyacyl-CoA dehydratase activity  3-hydroxy-arachidoyl-CoA dehydratase activity  3-hydroxy-behenoyl-CoA dehydratase activity  3-hydroxy-lignoceroyl-CoA dehydratase activity  
NDEx NetworkHACD2
Atlas of Cancer Signalling NetworkHACD2
Wikipedia pathwaysHACD2
Orthology - Evolution
OrthoDB201562
Phylogenetic Trees/Animal Genes : TreeFamHACD2
HOVERGENQ6Y1H2
HOGENOMQ6Y1H2
Homologs : HomoloGeneHACD2
Homology/Alignments : Family Browser (UCSC)HACD2
Gene fusions - Rearrangements
Fusion: Tumor Portal HACD2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHACD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HACD2
dbVarHACD2
ClinVarHACD2
1000_GenomesHACD2 
Exome Variant ServerHACD2
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP201562
Genomic Variants (DGV)HACD2 [DGVbeta]
DECIPHERHACD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHACD2 
Mutations
ICGC Data PortalHACD2 
TCGA Data PortalHACD2 
Broad Tumor PortalHACD2
OASIS PortalHACD2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDHACD2
BioMutasearch HACD2
DgiDB (Drug Gene Interaction Database)HACD2
DoCM (Curated mutations)HACD2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HACD2 (select a term)
intoGenHACD2
Cancer3DHACD2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615939   
Orphanet
MedgenHACD2
Genetic Testing Registry HACD2
NextProtQ6Y1H2 [Medical]
TSGene201562
GENETestsHACD2
Target ValidationHACD2
Huge Navigator HACD2 [HugePedia]
snp3D : Map Gene to Disease201562
BioCentury BCIQHACD2
ClinGenHACD2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD201562
Chemical/Pharm GKB GenePA33983
Clinical trialHACD2
Miscellaneous
canSAR (ICR)HACD2 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHACD2
EVEXHACD2
GoPubMedHACD2
iHOPHACD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 11:50:10 CET 2017

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