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HACD3 (3-hydroxyacyl-CoA dehydratase 3)

Identity

Alias_namesPTPLAD1
protein tyrosine phosphatase-like A domain containing 1
Alias_symbol (synonym)B-ind1
HSPC121
Other aliasB-IND1
BIND1
HGNC (Hugo) HACD3
LocusID (NCBI) 51495
Atlas_Id 55355
Location 15q22.31  [Link to chromosome band 15q22]
Location_base_pair Starts at 65822827 and ends at 65870693 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DPP8 (15q22.31) / HACD3 (15q22.31)GOLPH3L (1q21.3) / HACD3 (15q22.31)HACD3 (15q22.31) / AC069368.3 ()
TIMM21 (18q22.3) / HACD3 (15q22.31)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)HACD3   24175
Cards
Entrez_Gene (NCBI)HACD3  51495  3-hydroxyacyl-CoA dehydratase 3
AliasesB-IND1; BIND1; HSPC121; PTPLAD1
GeneCards (Weizmann)HACD3
Ensembl hg19 (Hinxton)ENSG00000074696 [Gene_View]  chr15:65822827-65870693 [Contig_View]  HACD3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000074696 [Gene_View]  chr15:65822827-65870693 [Contig_View]  HACD3 [Vega]
ICGC DataPortalENSG00000074696
TCGA cBioPortalHACD3
AceView (NCBI)HACD3
Genatlas (Paris)HACD3
WikiGenes51495
SOURCE (Princeton)HACD3
Genetics Home Reference (NIH)HACD3
Genomic and cartography
GoldenPath hg19 (UCSC)HACD3  -     chr15:65822827-65870693 +  15q22.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HACD3  -     15q22.31   [Description]    (hg38-Dec_2013)
EnsemblHACD3 - 15q22.31 [CytoView hg19]  HACD3 - 15q22.31 [CytoView hg38]
Mapping of homologs : NCBIHACD3 [Mapview hg19]  HACD3 [Mapview hg38]
OMIM615940   
Gene and transcription
Genbank (Entrez)AF161470 AJ271091 AK027421 AK074857 AK074898
RefSeq transcript (Entrez)NM_016395
RefSeq genomic (Entrez)NC_000015 NC_018926 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)HACD3
Cluster EST : UnigeneHs.512973 [ NCBI ]
CGAP (NCI)Hs.512973
Alternative Splicing GalleryENSG00000074696
Gene ExpressionHACD3 [ NCBI-GEO ]   HACD3 [ EBI - ARRAY_EXPRESS ]   HACD3 [ SEEK ]   HACD3 [ MEM ]
Gene Expression Viewer (FireBrowse)HACD3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51495
GTEX Portal (Tissue expression)HACD3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P035   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P035  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P035
Splice isoforms : SwissVarQ9P035
PhosPhoSitePlusQ9P035
Domaine pattern : Prosite (Expaxy)CS (PS51203)   
Domains : Interpro (EBI)CS_dom    HSP20-like_chaperone    Tyr_Pase-like_PTPLA   
Domain families : Pfam (Sanger)CS (PF04969)    PTPLA (PF04387)   
Domain families : Pfam (NCBI)pfam04969    pfam04387   
Conserved Domain (NCBI)HACD3
DMDM Disease mutations51495
Blocks (Seattle)HACD3
SuperfamilyQ9P035
Human Protein AtlasENSG00000074696
Peptide AtlasQ9P035
HPRD11037
IPIIPI00008998   IPI00787433   
Protein Interaction databases
DIP (DOE-UCLA)Q9P035
IntAct (EBI)Q9P035
FunCoupENSG00000074696
BioGRIDHACD3
STRING (EMBL)HACD3
ZODIACHACD3
Ontologies - Pathways
QuickGOQ9P035
Ontology : AmiGOGTPase activator activity  protein binding  cytoplasm  mitochondrion  endoplasmic reticulum  endoplasmic reticulum membrane  focal adhesion  I-kappaB kinase/NF-kappaB signaling  activation of JUN kinase activity  small GTPase mediated signal transduction  Rho protein signal transduction  integral component of membrane  Rac protein signal transduction  3-hydroxyacyl-CoA dehydratase activity  enzyme binding  fatty acid elongation  nuclear membrane  very long-chain fatty acid biosynthetic process  positive regulation of GTPase activity  positive regulation of viral genome replication  positive regulation by virus of viral protein levels in host cell  
Ontology : EGO-EBIGTPase activator activity  protein binding  cytoplasm  mitochondrion  endoplasmic reticulum  endoplasmic reticulum membrane  focal adhesion  I-kappaB kinase/NF-kappaB signaling  activation of JUN kinase activity  small GTPase mediated signal transduction  Rho protein signal transduction  integral component of membrane  Rac protein signal transduction  3-hydroxyacyl-CoA dehydratase activity  enzyme binding  fatty acid elongation  nuclear membrane  very long-chain fatty acid biosynthetic process  positive regulation of GTPase activity  positive regulation of viral genome replication  positive regulation by virus of viral protein levels in host cell  
NDEx NetworkHACD3
Atlas of Cancer Signalling NetworkHACD3
Wikipedia pathwaysHACD3
Orthology - Evolution
OrthoDB51495
GeneTree (enSembl)ENSG00000074696
Phylogenetic Trees/Animal Genes : TreeFamHACD3
HOVERGENQ9P035
HOGENOMQ9P035
Homologs : HomoloGeneHACD3
Homology/Alignments : Family Browser (UCSC)HACD3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHACD3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HACD3
dbVarHACD3
ClinVarHACD3
1000_GenomesHACD3 
Exome Variant ServerHACD3
ExAC (Exome Aggregation Consortium)HACD3 (select the gene name)
Genetic variants : HAPMAP51495
Genomic Variants (DGV)HACD3 [DGVbeta]
DECIPHER (Syndromes)15:65822827-65870693  ENSG00000074696
CONAN: Copy Number AnalysisHACD3 
Mutations
ICGC Data PortalHACD3 
TCGA Data PortalHACD3 
Broad Tumor PortalHACD3
OASIS PortalHACD3 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDHACD3
BioMutasearch HACD3
DgiDB (Drug Gene Interaction Database)HACD3
DoCM (Curated mutations)HACD3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HACD3 (select a term)
intoGenHACD3
Cancer3DHACD3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615940   
Orphanet
MedgenHACD3
Genetic Testing Registry HACD3
NextProtQ9P035 [Medical]
TSGene51495
GENETestsHACD3
Huge Navigator HACD3 [HugePedia]
snp3D : Map Gene to Disease51495
BioCentury BCIQHACD3
ClinGenHACD3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51495
Chemical/Pharm GKB GenePA142671113
Clinical trialHACD3
Miscellaneous
canSAR (ICR)HACD3 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHACD3
EVEXHACD3
GoPubMedHACD3
iHOPHACD3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:03:20 CEST 2017

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