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HACD4 (3-hydroxyacyl-CoA dehydratase 4)

Identity

Alias_namesPTPLAD2
protein tyrosine phosphatase-like A domain containing 2
Alias_symbol (synonym)Em:AL662879.1
OTTHUMG00000021016
Other alias
HGNC (Hugo) HACD4
LocusID (NCBI) 401494
Atlas_Id 53913
Location 9p21.3  [Link to chromosome band 9p21]
Location_base_pair Starts at 21006365 and ends at 21031635 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FOCAD (9p21.3) / HACD4 (9p21.3)MAP4K3 (2p22.1) / HACD4 (9p21.3)PLAA (9p21.2) / HACD4 (9p21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  del(9p) in Acute Lymphoblastic Leukemia


External links

Nomenclature
HGNC (Hugo)HACD4   20920
Cards
Entrez_Gene (NCBI)HACD4  401494  3-hydroxyacyl-CoA dehydratase 4
AliasesPTPLAD2
GeneCards (Weizmann)HACD4
Ensembl hg19 (Hinxton)ENSG00000188921 [Gene_View]  chr9:21006365-21031635 [Contig_View]  HACD4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000188921 [Gene_View]  chr9:21006365-21031635 [Contig_View]  HACD4 [Vega]
ICGC DataPortalENSG00000188921
TCGA cBioPortalHACD4
AceView (NCBI)HACD4
Genatlas (Paris)HACD4
WikiGenes401494
SOURCE (Princeton)HACD4
Genetics Home Reference (NIH)HACD4
Genomic and cartography
GoldenPath hg19 (UCSC)HACD4  -     chr9:21006365-21031635 -  9p21.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HACD4  -     9p21.3   [Description]    (hg38-Dec_2013)
EnsemblHACD4 - 9p21.3 [CytoView hg19]  HACD4 - 9p21.3 [CytoView hg38]
Mapping of homologs : NCBIHACD4 [Mapview hg19]  HACD4 [Mapview hg38]
OMIM615941   
Gene and transcription
Genbank (Entrez)BC114215 BX538052 BX648779 DA333010 HY118500
RefSeq transcript (Entrez)NM_001010915 NM_001321883 NM_001321903
RefSeq genomic (Entrez)NC_000009 NC_018920 NT_008413 NW_004929342
Consensus coding sequences : CCDS (NCBI)HACD4
Cluster EST : UnigeneHs.716678 [ NCBI ]
CGAP (NCI)Hs.716678
Alternative Splicing GalleryENSG00000188921
Gene ExpressionHACD4 [ NCBI-GEO ]   HACD4 [ EBI - ARRAY_EXPRESS ]   HACD4 [ SEEK ]   HACD4 [ MEM ]
Gene Expression Viewer (FireBrowse)HACD4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)401494
GTEX Portal (Tissue expression)HACD4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5VWC8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5VWC8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5VWC8
Splice isoforms : SwissVarQ5VWC8
PhosPhoSitePlusQ5VWC8
Domains : Interpro (EBI)Tyr_Pase-like_PTPLA   
Domain families : Pfam (Sanger)PTPLA (PF04387)   
Domain families : Pfam (NCBI)pfam04387   
Conserved Domain (NCBI)HACD4
DMDM Disease mutations401494
Blocks (Seattle)HACD4
SuperfamilyQ5VWC8
Human Protein AtlasENSG00000188921
Peptide AtlasQ5VWC8
HPRD17392
IPIIPI00401243   
Protein Interaction databases
DIP (DOE-UCLA)Q5VWC8
IntAct (EBI)Q5VWC8
FunCoupENSG00000188921
BioGRIDHACD4
STRING (EMBL)HACD4
ZODIACHACD4
Ontologies - Pathways
QuickGOQ5VWC8
Ontology : AmiGOendoplasmic reticulum  endoplasmic reticulum membrane  integral component of membrane  3-hydroxyacyl-CoA dehydratase activity  enzyme binding  fatty acid elongation  very long-chain fatty acid biosynthetic process  
Ontology : EGO-EBIendoplasmic reticulum  endoplasmic reticulum membrane  integral component of membrane  3-hydroxyacyl-CoA dehydratase activity  enzyme binding  fatty acid elongation  very long-chain fatty acid biosynthetic process  
NDEx NetworkHACD4
Atlas of Cancer Signalling NetworkHACD4
Wikipedia pathwaysHACD4
Orthology - Evolution
OrthoDB401494
GeneTree (enSembl)ENSG00000188921
Phylogenetic Trees/Animal Genes : TreeFamHACD4
HOVERGENQ5VWC8
HOGENOMQ5VWC8
Homologs : HomoloGeneHACD4
Homology/Alignments : Family Browser (UCSC)HACD4
Gene fusions - Rearrangements
Fusion : MitelmanFOCAD/HACD4 [9p21.3/9p21.3]  [t(9;9)(p21;p21)]  
Fusion : MitelmanMAP4K3/HACD4 [2p22.1/9p21.3]  [t(2;9)(p22;p21)]  
Fusion : MitelmanPLAA/HACD4 [9p21.2/9p21.3]  [t(9;9)(p21;p21)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHACD4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HACD4
dbVarHACD4
ClinVarHACD4
1000_GenomesHACD4 
Exome Variant ServerHACD4
ExAC (Exome Aggregation Consortium)HACD4 (select the gene name)
Genetic variants : HAPMAP401494
Genomic Variants (DGV)HACD4 [DGVbeta]
DECIPHER (Syndromes)9:21006365-21031635  ENSG00000188921
CONAN: Copy Number AnalysisHACD4 
Mutations
ICGC Data PortalHACD4 
TCGA Data PortalHACD4 
Broad Tumor PortalHACD4
OASIS PortalHACD4 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDHACD4
BioMutasearch HACD4
DgiDB (Drug Gene Interaction Database)HACD4
DoCM (Curated mutations)HACD4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HACD4 (select a term)
intoGenHACD4
Cancer3DHACD4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615941   
Orphanet
MedgenHACD4
Genetic Testing Registry HACD4
NextProtQ5VWC8 [Medical]
TSGene401494
GENETestsHACD4
Huge Navigator HACD4 [HugePedia]
snp3D : Map Gene to Disease401494
BioCentury BCIQHACD4
ClinGenHACD4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD401494
Chemical/Pharm GKB GenePA142671114
Clinical trialHACD4
Miscellaneous
canSAR (ICR)HACD4 (select the gene name)
Probes
Litterature
PubMed5 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHACD4
EVEXHACD4
GoPubMedHACD4
iHOPHACD4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:03:21 CEST 2017

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