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HADH (hydroxyacyl-CoA dehydrogenase)

Identity

Alias_namesHADHSC
L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain
hydroxyacyl-Coenzyme A dehydrogenase
Alias_symbol (synonym)HADH1
SCHAD
Other aliasHAD
HCDH
HHF4
MSCHAD
HGNC (Hugo) HADH
LocusID (NCBI) 3033
Atlas_Id 64159
Location 4q25  [Link to chromosome band 4q25]
Location_base_pair Starts at 108910870 and ends at 108956331 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FRAS1 (4q21.21) / HADH (4q25)HADH (4q25) / ATP5B (12q13.3)HADH (4q25) / HADH (4q25)
HADH (4q25) / MEIS1 (2p14)HADH (4q25) / NCL (2q37.1)LEF1 (4q25) / HADH (4q25)
TSPAN16 (19p13.2) / HADH (4q25)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HADH   4799
Cards
Entrez_Gene (NCBI)HADH  3033  hydroxyacyl-CoA dehydrogenase
AliasesHAD; HADH1; HADHSC; HCDH; 
HHF4; MSCHAD; SCHAD
GeneCards (Weizmann)HADH
Ensembl hg19 (Hinxton)ENSG00000138796 [Gene_View]  chr4:108910870-108956331 [Contig_View]  HADH [Vega]
Ensembl hg38 (Hinxton)ENSG00000138796 [Gene_View]  chr4:108910870-108956331 [Contig_View]  HADH [Vega]
ICGC DataPortalENSG00000138796
TCGA cBioPortalHADH
AceView (NCBI)HADH
Genatlas (Paris)HADH
WikiGenes3033
SOURCE (Princeton)HADH
Genetics Home Reference (NIH)HADH
Genomic and cartography
GoldenPath hg19 (UCSC)HADH  -     chr4:108910870-108956331 +  4q25   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HADH  -     4q25   [Description]    (hg38-Dec_2013)
EnsemblHADH - 4q25 [CytoView hg19]  HADH - 4q25 [CytoView hg38]
Mapping of homologs : NCBIHADH [Mapview hg19]  HADH [Mapview hg38]
OMIM231530   601609   609975   
Gene and transcription
Genbank (Entrez)AF001902 AF001903 AI017358 AK096018 AK314444
RefSeq transcript (Entrez)NM_001184705 NM_005327
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_008156 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)HADH
Cluster EST : UnigeneHs.438289 [ NCBI ]
CGAP (NCI)Hs.438289
Alternative Splicing GalleryENSG00000138796
Gene ExpressionHADH [ NCBI-GEO ]   HADH [ EBI - ARRAY_EXPRESS ]   HADH [ SEEK ]   HADH [ MEM ]
Gene Expression Viewer (FireBrowse)HADH [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3033
GTEX Portal (Tissue expression)HADH
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16836   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16836  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16836
Splice isoforms : SwissVarQ16836
Catalytic activity : Enzyme1.1.1.35 [ Enzyme-Expasy ]   1.1.1.351.1.1.35 [ IntEnz-EBI ]   1.1.1.35 [ BRENDA ]   1.1.1.35 [ KEGG ]   
PhosPhoSitePlusQ16836
Domaine pattern : Prosite (Expaxy)3HCDH (PS00067)   
Domains : Interpro (EBI)3-OHacyl-CoA_DH    3-OHacyl-CoA_DH_CS    3-OHacyl-CoA_DH_NAD-bd    3HC_DH_C    6-PGluconate_DH_C-like    6PGD_dom_2    NAD(P)-bd_dom   
Domain families : Pfam (Sanger)3HCDH (PF00725)    3HCDH_N (PF02737)   
Domain families : Pfam (NCBI)pfam00725    pfam02737   
Conserved Domain (NCBI)HADH
DMDM Disease mutations3033
Blocks (Seattle)HADH
PDB (SRS)1F0Y    1F12    1F14    1F17    1IL0    1LSJ    1LSO    1M75    1M76    2HDH    3HAD    3RQS   
PDB (PDBSum)1F0Y    1F12    1F14    1F17    1IL0    1LSJ    1LSO    1M75    1M76    2HDH    3HAD    3RQS   
PDB (IMB)1F0Y    1F12    1F14    1F17    1IL0    1LSJ    1LSO    1M75    1M76    2HDH    3HAD    3RQS   
PDB (RSDB)1F0Y    1F12    1F14    1F17    1IL0    1LSJ    1LSO    1M75    1M76    2HDH    3HAD    3RQS   
Structural Biology KnowledgeBase1F0Y    1F12    1F14    1F17    1IL0    1LSJ    1LSO    1M75    1M76    2HDH    3HAD    3RQS   
SCOP (Structural Classification of Proteins)1F0Y    1F12    1F14    1F17    1IL0    1LSJ    1LSO    1M75    1M76    2HDH    3HAD    3RQS   
CATH (Classification of proteins structures)1F0Y    1F12    1F14    1F17    1IL0    1LSJ    1LSO    1M75    1M76    2HDH    3HAD    3RQS   
SuperfamilyQ16836
Human Protein AtlasENSG00000138796
Peptide AtlasQ16836
IPIIPI00294398   IPI00298406   IPI00902588   IPI00967896   
Protein Interaction databases
DIP (DOE-UCLA)Q16836
IntAct (EBI)Q16836
FunCoupENSG00000138796
BioGRIDHADH
STRING (EMBL)HADH
ZODIACHADH
Ontologies - Pathways
QuickGOQ16836
Ontology : AmiGO3-hydroxyacyl-CoA dehydrogenase activity  nucleoplasm  cytoplasm  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  fatty acid beta-oxidation  fatty acid beta-oxidation  response to activity  response to insulin  response to drug  cellular lipid metabolic process  small molecule metabolic process  negative regulation of insulin secretion  NAD+ binding  
Ontology : EGO-EBI3-hydroxyacyl-CoA dehydrogenase activity  nucleoplasm  cytoplasm  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  fatty acid beta-oxidation  fatty acid beta-oxidation  response to activity  response to insulin  response to drug  cellular lipid metabolic process  small molecule metabolic process  negative regulation of insulin secretion  NAD+ binding  
Pathways : KEGGFatty acid elongation    Fatty acid degradation    Valine, leucine and isoleucine degradation    Lysine degradation    Tryptophan metabolism    Butanoate metabolism   
NDEx NetworkHADH
Atlas of Cancer Signalling NetworkHADH
Wikipedia pathwaysHADH
Orthology - Evolution
OrthoDB3033
GeneTree (enSembl)ENSG00000138796
Phylogenetic Trees/Animal Genes : TreeFamHADH
HOVERGENQ16836
HOGENOMQ16836
Homologs : HomoloGeneHADH
Homology/Alignments : Family Browser (UCSC)HADH
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHADH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HADH
dbVarHADH
ClinVarHADH
1000_GenomesHADH 
Exome Variant ServerHADH
ExAC (Exome Aggregation Consortium)HADH (select the gene name)
Genetic variants : HAPMAP3033
Genomic Variants (DGV)HADH [DGVbeta]
DECIPHER (Syndromes)4:108910870-108956331  ENSG00000138796
CONAN: Copy Number AnalysisHADH 
Mutations
ICGC Data PortalHADH 
TCGA Data PortalHADH 
Broad Tumor PortalHADH
OASIS PortalHADH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHADH  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHADH
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch HADH
DgiDB (Drug Gene Interaction Database)HADH
DoCM (Curated mutations)HADH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HADH (select a term)
intoGenHADH
Cancer3DHADH(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM231530    601609    609975   
Orphanet10987   
MedgenHADH
Genetic Testing Registry HADH
NextProtQ16836 [Medical]
TSGene3033
GENETestsHADH
Huge Navigator HADH [HugePedia]
snp3D : Map Gene to Disease3033
BioCentury BCIQHADH
ClinGenHADH
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3033
Chemical/Pharm GKB GenePA29173
Clinical trialHADH
Miscellaneous
canSAR (ICR)HADH (select the gene name)
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHADH
EVEXHADH
GoPubMedHADH
iHOPHADH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:07:22 CET 2017

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