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HAGH (hydroxyacylglutathione hydrolase)

Identity

Alias_nameshydroxyacyl glutathione hydrolase
Alias_symbol (synonym)GLO2
GLXII
HAGH1
Other aliasGLX2
HGNC (Hugo) HAGH
LocusID (NCBI) 3029
Atlas_Id 46037
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 1809103 and ends at 1827194 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HAGH   4805
Cards
Entrez_Gene (NCBI)HAGH  3029  hydroxyacylglutathione hydrolase
AliasesGLO2; GLX2; GLXII; HAGH1
GeneCards (Weizmann)HAGH
Ensembl hg19 (Hinxton)ENSG00000063854 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000063854 [Gene_View]  chr16:1809103-1827194 [Contig_View]  HAGH [Vega]
ICGC DataPortalENSG00000063854
TCGA cBioPortalHAGH
AceView (NCBI)HAGH
Genatlas (Paris)HAGH
WikiGenes3029
SOURCE (Princeton)HAGH
Genetics Home Reference (NIH)HAGH
Genomic and cartography
GoldenPath hg38 (UCSC)HAGH  -     chr16:1809103-1827194 -  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HAGH  -     16p13.3   [Description]    (hg19-Feb_2009)
EnsemblHAGH - 16p13.3 [CytoView hg19]  HAGH - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBIHAGH [Mapview hg19]  HAGH [Mapview hg38]
OMIM138760   614033   
Gene and transcription
Genbank (Entrez)AK054943 AK290155 AK298174 AK299173 AK299993
RefSeq transcript (Entrez)NM_001040427 NM_001286249 NM_005326
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HAGH
Cluster EST : UnigeneHs.157394 [ NCBI ]
CGAP (NCI)Hs.157394
Alternative Splicing GalleryENSG00000063854
Gene ExpressionHAGH [ NCBI-GEO ]   HAGH [ EBI - ARRAY_EXPRESS ]   HAGH [ SEEK ]   HAGH [ MEM ]
Gene Expression Viewer (FireBrowse)HAGH [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3029
GTEX Portal (Tissue expression)HAGH
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16775   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16775  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16775
Splice isoforms : SwissVarQ16775
Catalytic activity : Enzyme3.1.2.6 [ Enzyme-Expasy ]   3.1.2.63.1.2.6 [ IntEnz-EBI ]   3.1.2.6 [ BRENDA ]   3.1.2.6 [ KEGG ]   
PhosPhoSitePlusQ16775
Domains : Interpro (EBI)HAGH_C    Hydroxyacylglutathione_Hdrlase    Metallo-B-lactamas   
Domain families : Pfam (Sanger)HAGH_C (PF16123)    Lactamase_B (PF00753)   
Domain families : Pfam (NCBI)pfam16123    pfam00753   
Domain families : Smart (EMBL)Lactamase_B (SM00849)  
Conserved Domain (NCBI)HAGH
DMDM Disease mutations3029
Blocks (Seattle)HAGH
PDB (SRS)1QH3    1QH5    2F50   
PDB (PDBSum)1QH3    1QH5    2F50   
PDB (IMB)1QH3    1QH5    2F50   
PDB (RSDB)1QH3    1QH5    2F50   
Structural Biology KnowledgeBase1QH3    1QH5    2F50   
SCOP (Structural Classification of Proteins)1QH3    1QH5    2F50   
CATH (Classification of proteins structures)1QH3    1QH5    2F50   
SuperfamilyQ16775
Human Protein AtlasENSG00000063854
Peptide AtlasQ16775
HPRD00731
IPIIPI00003933   IPI00745553   IPI00909928   
Protein Interaction databases
DIP (DOE-UCLA)Q16775
IntAct (EBI)Q16775
FunCoupENSG00000063854
BioGRIDHAGH
STRING (EMBL)HAGH
ZODIACHAGH
Ontologies - Pathways
QuickGOQ16775
Ontology : AmiGOhydroxyacylglutathione hydrolase activity  hydroxyacylglutathione hydrolase activity  protein binding  mitochondrial matrix  cytosol  pyruvate metabolic process  glutathione biosynthetic process  methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione  metal ion binding  extracellular exosome  
Ontology : EGO-EBIhydroxyacylglutathione hydrolase activity  hydroxyacylglutathione hydrolase activity  protein binding  mitochondrial matrix  cytosol  pyruvate metabolic process  glutathione biosynthetic process  methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione  metal ion binding  extracellular exosome  
Pathways : KEGGPyruvate metabolism   
NDEx NetworkHAGH
Atlas of Cancer Signalling NetworkHAGH
Wikipedia pathwaysHAGH
Orthology - Evolution
OrthoDB3029
GeneTree (enSembl)ENSG00000063854
Phylogenetic Trees/Animal Genes : TreeFamHAGH
HOVERGENQ16775
HOGENOMQ16775
Homologs : HomoloGeneHAGH
Homology/Alignments : Family Browser (UCSC)HAGH
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHAGH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HAGH
dbVarHAGH
ClinVarHAGH
1000_GenomesHAGH 
Exome Variant ServerHAGH
ExAC (Exome Aggregation Consortium)HAGH (select the gene name)
Genetic variants : HAPMAP3029
Genomic Variants (DGV)HAGH [DGVbeta]
DECIPHERHAGH [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHAGH 
Mutations
ICGC Data PortalHAGH 
TCGA Data PortalHAGH 
Broad Tumor PortalHAGH
OASIS PortalHAGH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHAGH  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHAGH
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch HAGH
DgiDB (Drug Gene Interaction Database)HAGH
DoCM (Curated mutations)HAGH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HAGH (select a term)
intoGenHAGH
Cancer3DHAGH(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138760    614033   
Orphanet
MedgenHAGH
Genetic Testing Registry HAGH
NextProtQ16775 [Medical]
TSGene3029
GENETestsHAGH
Target ValidationHAGH
Huge Navigator HAGH [HugePedia]
snp3D : Map Gene to Disease3029
BioCentury BCIQHAGH
ClinGenHAGH
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3029
Chemical/Pharm GKB GenePA29179
Clinical trialHAGH
Miscellaneous
canSAR (ICR)HAGH (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHAGH
EVEXHAGH
GoPubMedHAGH
iHOPHAGH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:36:21 CEST 2017

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