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HAMP (hepcidin antimicrobial peptide)

Identity

Alias_symbol (synonym)LEAP-1
HEPC
HFE2B
LEAP1
Other aliasPLTR
HGNC (Hugo) HAMP
LocusID (NCBI) 57817
Atlas_Id 50294
Location 19q13.12  [Link to chromosome band 19q13]
Location_base_pair Starts at 35773249 and ends at 35776045 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HAMP   15598
LRG (Locus Reference Genomic)LRG_791
Cards
Entrez_Gene (NCBI)HAMP  57817  hepcidin antimicrobial peptide
AliasesHEPC; HFE2B; LEAP1; PLTR
GeneCards (Weizmann)HAMP
Ensembl hg19 (Hinxton)ENSG00000105697 [Gene_View]  chr19:35773249-35776045 [Contig_View]  HAMP [Vega]
Ensembl hg38 (Hinxton)ENSG00000105697 [Gene_View]  chr19:35773249-35776045 [Contig_View]  HAMP [Vega]
ICGC DataPortalENSG00000105697
TCGA cBioPortalHAMP
AceView (NCBI)HAMP
Genatlas (Paris)HAMP
WikiGenes57817
SOURCE (Princeton)HAMP
Genetics Home Reference (NIH)HAMP
Genomic and cartography
GoldenPath hg19 (UCSC)HAMP  -     chr19:35773249-35776045 +  19q13.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HAMP  -     19q13.12   [Description]    (hg38-Dec_2013)
EnsemblHAMP - 19q13.12 [CytoView hg19]  HAMP - 19q13.12 [CytoView hg38]
Mapping of homologs : NCBIHAMP [Mapview hg19]  HAMP [Mapview hg38]
OMIM606464   613313   
Gene and transcription
Genbank (Entrez)AF131292 AF147355 AF309489 AJ277280 AK096110
RefSeq transcript (Entrez)NM_021175
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_011563 NT_011109 NW_004929415
Consensus coding sequences : CCDS (NCBI)HAMP
Cluster EST : UnigeneHs.8821 [ NCBI ]
CGAP (NCI)Hs.8821
Alternative Splicing GalleryENSG00000105697
Gene ExpressionHAMP [ NCBI-GEO ]   HAMP [ EBI - ARRAY_EXPRESS ]   HAMP [ SEEK ]   HAMP [ MEM ]
Gene Expression Viewer (FireBrowse)HAMP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57817
GTEX Portal (Tissue expression)HAMP
Protein : pattern, domain, 3D structure
UniProt/SwissProtP81172   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP81172  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP81172
Splice isoforms : SwissVarP81172
PhosPhoSitePlusP81172
Domains : Interpro (EBI)Hepcidin   
Domain families : Pfam (Sanger)Hepcidin (PF06446)   
Domain families : Pfam (NCBI)pfam06446   
Conserved Domain (NCBI)HAMP
DMDM Disease mutations57817
Blocks (Seattle)HAMP
PDB (SRS)1M4E    1M4F    2KEF    3H0T    4QAE   
PDB (PDBSum)1M4E    1M4F    2KEF    3H0T    4QAE   
PDB (IMB)1M4E    1M4F    2KEF    3H0T    4QAE   
PDB (RSDB)1M4E    1M4F    2KEF    3H0T    4QAE   
Structural Biology KnowledgeBase1M4E    1M4F    2KEF    3H0T    4QAE   
SCOP (Structural Classification of Proteins)1M4E    1M4F    2KEF    3H0T    4QAE   
CATH (Classification of proteins structures)1M4E    1M4F    2KEF    3H0T    4QAE   
SuperfamilyP81172
Human Protein AtlasENSG00000105697
Peptide AtlasP81172
HPRD05925
IPIIPI00025992   IPI00432049   
Protein Interaction databases
DIP (DOE-UCLA)P81172
IntAct (EBI)P81172
FunCoupENSG00000105697
BioGRIDHAMP
STRING (EMBL)HAMP
ZODIACHAMP
Ontologies - Pathways
QuickGOP81172
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  positive regulation of receptor internalization  receptor binding  hormone activity  hormone activity  extracellular region  extracellular space  cell  cellular iron ion homeostasis  immune response  response to iron ion  killing of cells of other organism  negative regulation of ion transmembrane transporter activity  defense response to bacterium  apical cortex  defense response to fungus  multicellular organismal iron ion homeostasis  iron channel inhibitor activity  positive regulation of protein polyubiquitination  negative regulation of ferrous iron export  negative regulation of iron channel activity  negative regulation of intestinal absorption  positive regulation of receptor catabolic process  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  positive regulation of receptor internalization  receptor binding  hormone activity  hormone activity  extracellular region  extracellular space  cell  cellular iron ion homeostasis  immune response  response to iron ion  killing of cells of other organism  negative regulation of ion transmembrane transporter activity  defense response to bacterium  apical cortex  defense response to fungus  multicellular organismal iron ion homeostasis  iron channel inhibitor activity  positive regulation of protein polyubiquitination  negative regulation of ferrous iron export  negative regulation of iron channel activity  negative regulation of intestinal absorption  positive regulation of receptor catabolic process  
NDEx NetworkHAMP
Atlas of Cancer Signalling NetworkHAMP
Wikipedia pathwaysHAMP
Orthology - Evolution
OrthoDB57817
GeneTree (enSembl)ENSG00000105697
Phylogenetic Trees/Animal Genes : TreeFamHAMP
HOVERGENP81172
HOGENOMP81172
Homologs : HomoloGeneHAMP
Homology/Alignments : Family Browser (UCSC)HAMP
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHAMP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HAMP
dbVarHAMP
ClinVarHAMP
1000_GenomesHAMP 
Exome Variant ServerHAMP
ExAC (Exome Aggregation Consortium)HAMP (select the gene name)
Genetic variants : HAPMAP57817
Genomic Variants (DGV)HAMP [DGVbeta]
DECIPHER (Syndromes)19:35773249-35776045  ENSG00000105697
CONAN: Copy Number AnalysisHAMP 
Mutations
ICGC Data PortalHAMP 
TCGA Data PortalHAMP 
Broad Tumor PortalHAMP
OASIS PortalHAMP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHAMP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHAMP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)FH UCL BHF
BioMutasearch HAMP
DgiDB (Drug Gene Interaction Database)HAMP
DoCM (Curated mutations)HAMP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HAMP (select a term)
intoGenHAMP
Cancer3DHAMP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606464    613313   
Orphanet11256   
MedgenHAMP
Genetic Testing Registry HAMP
NextProtP81172 [Medical]
TSGene57817
GENETestsHAMP
Huge Navigator HAMP [HugePedia]
snp3D : Map Gene to Disease57817
BioCentury BCIQHAMP
ClinGenHAMP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57817
Chemical/Pharm GKB GenePA29182
Clinical trialHAMP
Miscellaneous
canSAR (ICR)HAMP (select the gene name)
Probes
Litterature
PubMed316 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHAMP
EVEXHAMP
GoPubMedHAMP
iHOPHAMP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Mar 14 13:08:33 CET 2017

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