Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HAND2 (heart and neural crest derivatives expressed 2)

Identity

Alias_symbol (synonym)dHand
Thing2
Hed
bHLHa26
Other aliasDHAND2
HGNC (Hugo) HAND2
LocusID (NCBI) 9464
Atlas_Id 56467
Location 4q34.1  [Link to chromosome band 4q34]
Location_base_pair Starts at 173526501 and ends at 173530227 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HAND2 (4q34.1) / LPCAT1 (5p15.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HAND2   4808
Cards
Entrez_Gene (NCBI)HAND2  9464  heart and neural crest derivatives expressed 2
AliasesDHAND2; Hed; Thing2; bHLHa26; 
dHand
GeneCards (Weizmann)HAND2
Ensembl hg19 (Hinxton)ENSG00000164107 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164107 [Gene_View]  chr4:173526501-173530227 [Contig_View]  HAND2 [Vega]
ICGC DataPortalENSG00000164107
TCGA cBioPortalHAND2
AceView (NCBI)HAND2
Genatlas (Paris)HAND2
WikiGenes9464
SOURCE (Princeton)HAND2
Genetics Home Reference (NIH)HAND2
Genomic and cartography
GoldenPath hg38 (UCSC)HAND2  -     chr4:173526501-173530227 -  4q34.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HAND2  -     4q34.1   [Description]    (hg19-Feb_2009)
EnsemblHAND2 - 4q34.1 [CytoView hg19]  HAND2 - 4q34.1 [CytoView hg38]
Mapping of homologs : NCBIHAND2 [Mapview hg19]  HAND2 [Mapview hg38]
OMIM602407   
Gene and transcription
Genbank (Entrez)AF087940 AK122739 BC101406 BC101974 BC109383
RefSeq transcript (Entrez)NM_021973
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HAND2
Cluster EST : UnigeneHs.388245 [ NCBI ]
CGAP (NCI)Hs.388245
Alternative Splicing GalleryENSG00000164107
Gene ExpressionHAND2 [ NCBI-GEO ]   HAND2 [ EBI - ARRAY_EXPRESS ]   HAND2 [ SEEK ]   HAND2 [ MEM ]
Gene Expression Viewer (FireBrowse)HAND2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9464
GTEX Portal (Tissue expression)HAND2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61296   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61296  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61296
Splice isoforms : SwissVarP61296
PhosPhoSitePlusP61296
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)   
Domains : Interpro (EBI)bHLH_dom   
Domain families : Pfam (Sanger)HLH (PF00010)   
Domain families : Pfam (NCBI)pfam00010   
Domain families : Smart (EMBL)HLH (SM00353)  
Conserved Domain (NCBI)HAND2
DMDM Disease mutations9464
Blocks (Seattle)HAND2
SuperfamilyP61296
Human Protein AtlasENSG00000164107
Peptide AtlasP61296
HPRD03872
IPIIPI00029953   IPI00967983   IPI00874278   
Protein Interaction databases
DIP (DOE-UCLA)P61296
IntAct (EBI)P61296
FunCoupENSG00000164107
BioGRIDHAND2
STRING (EMBL)HAND2
ZODIACHAND2
Ontologies - Pathways
QuickGOP61296
Ontology : AmiGOnuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  angiogenesis  in utero embryonic development  heart looping  suckling behavior  cardiac right ventricle formation  cardiac neural crest cell migration involved in outflow tract morphogenesis  regulation of secondary heart field cardioblast proliferation  apoptotic process involved in heart morphogenesis  noradrenergic neuron differentiation  AT DNA binding  transcription coactivator activity  protein binding  transcription factor complex  transcription from RNA polymerase II promoter  heart development  adult heart development  transcription factor binding  mesenchymal cell proliferation  positive regulation of cardiac muscle hypertrophy  positive regulation of cardiac muscle hypertrophy  positive regulation of gene expression  negative regulation of gene expression  negative regulation of cardiac muscle cell apoptotic process  activating transcription factor binding  regulation of tissue remodeling  odontogenesis of dentin-containing tooth  embryonic digit morphogenesis  protein homodimerization activity  protein complex  negative regulation of DNA binding  negative regulation of sequence-specific DNA binding transcription factor activity  tongue development  transcription regulatory region DNA binding  negative regulation of osteoblast differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  sympathetic nervous system development  thymus development  peripheral nervous system neuron development  palate development  cartilage morphogenesis  coronary artery morphogenesis  visceral serous pericardium development  cardiac neural crest cell development involved in outflow tract morphogenesis  cell proliferation involved in outflow tract morphogenesis  positive regulation of ERK1 and ERK2 cascade  E-box binding  E-box binding  positive regulation of p38MAPK cascade  positive regulation of transcription regulatory region DNA binding  positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process  positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis  
Ontology : EGO-EBInuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  angiogenesis  in utero embryonic development  heart looping  suckling behavior  cardiac right ventricle formation  cardiac neural crest cell migration involved in outflow tract morphogenesis  regulation of secondary heart field cardioblast proliferation  apoptotic process involved in heart morphogenesis  noradrenergic neuron differentiation  AT DNA binding  transcription coactivator activity  protein binding  transcription factor complex  transcription from RNA polymerase II promoter  heart development  adult heart development  transcription factor binding  mesenchymal cell proliferation  positive regulation of cardiac muscle hypertrophy  positive regulation of cardiac muscle hypertrophy  positive regulation of gene expression  negative regulation of gene expression  negative regulation of cardiac muscle cell apoptotic process  activating transcription factor binding  regulation of tissue remodeling  odontogenesis of dentin-containing tooth  embryonic digit morphogenesis  protein homodimerization activity  protein complex  negative regulation of DNA binding  negative regulation of sequence-specific DNA binding transcription factor activity  tongue development  transcription regulatory region DNA binding  negative regulation of osteoblast differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  sympathetic nervous system development  thymus development  peripheral nervous system neuron development  palate development  cartilage morphogenesis  coronary artery morphogenesis  visceral serous pericardium development  cardiac neural crest cell development involved in outflow tract morphogenesis  cell proliferation involved in outflow tract morphogenesis  positive regulation of ERK1 and ERK2 cascade  E-box binding  E-box binding  positive regulation of p38MAPK cascade  positive regulation of transcription regulatory region DNA binding  positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process  positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis  
Pathways : BIOCARTANFAT and Hypertrophy of the heart (Transcription in the broken heart) [Genes]   
NDEx NetworkHAND2
Atlas of Cancer Signalling NetworkHAND2
Wikipedia pathwaysHAND2
Orthology - Evolution
OrthoDB9464
GeneTree (enSembl)ENSG00000164107
Phylogenetic Trees/Animal Genes : TreeFamHAND2
HOVERGENP61296
HOGENOMP61296
Homologs : HomoloGeneHAND2
Homology/Alignments : Family Browser (UCSC)HAND2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHAND2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HAND2
dbVarHAND2
ClinVarHAND2
1000_GenomesHAND2 
Exome Variant ServerHAND2
ExAC (Exome Aggregation Consortium)HAND2 (select the gene name)
Genetic variants : HAPMAP9464
Genomic Variants (DGV)HAND2 [DGVbeta]
DECIPHERHAND2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHAND2 
Mutations
ICGC Data PortalHAND2 
TCGA Data PortalHAND2 
Broad Tumor PortalHAND2
OASIS PortalHAND2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHAND2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHAND2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HAND2
DgiDB (Drug Gene Interaction Database)HAND2
DoCM (Curated mutations)HAND2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HAND2 (select a term)
intoGenHAND2
Cancer3DHAND2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602407   
Orphanet
MedgenHAND2
Genetic Testing Registry HAND2
NextProtP61296 [Medical]
TSGene9464
GENETestsHAND2
Target ValidationHAND2
Huge Navigator HAND2 [HugePedia]
snp3D : Map Gene to Disease9464
BioCentury BCIQHAND2
ClinGenHAND2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9464
Chemical/Pharm GKB GenePA29184
Clinical trialHAND2
Miscellaneous
canSAR (ICR)HAND2 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHAND2
EVEXHAND2
GoPubMedHAND2
iHOPHAND2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:02:42 CEST 2017

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