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HARS (histidyl-tRNA synthetase)

Identity

Alias_namescytoplasmic
Other aliasCMT2W
HRS
USH3B
HGNC (Hugo) HARS
LocusID (NCBI) 3035
Atlas_Id 49937
Location 5q31.3  [Link to chromosome band 5q31]
Location_base_pair Starts at 140053489 and ends at 140071312 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
HARS (5q31.3) / CLINT1 (5q33.3)HARS (5q31.3) / DUSP6 (12q21.33)HARS (5q31.3) / FAM53C (5q31.2)
HARS (5q31.3) / UBE2D2 (5q31.2)HARS 5q31.3 / CLINT1 5q33.3HARS 5q31.3 / FAM53C 5q31.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HARS   4816
Cards
Entrez_Gene (NCBI)HARS  3035  histidyl-tRNA synthetase
AliasesCMT2W; HRS; USH3B
GeneCards (Weizmann)HARS
Ensembl hg19 (Hinxton)ENSG00000170445 [Gene_View]  chr5:140053489-140071312 [Contig_View]  HARS [Vega]
Ensembl hg38 (Hinxton)ENSG00000170445 [Gene_View]  chr5:140053489-140071312 [Contig_View]  HARS [Vega]
ICGC DataPortalENSG00000170445
TCGA cBioPortalHARS
AceView (NCBI)HARS
Genatlas (Paris)HARS
WikiGenes3035
SOURCE (Princeton)HARS
Genetics Home Reference (NIH)HARS
Genomic and cartography
GoldenPath hg19 (UCSC)HARS  -     chr5:140053489-140071312 -  5q31.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HARS  -     5q31.3   [Description]    (hg38-Dec_2013)
EnsemblHARS - 5q31.3 [CytoView hg19]  HARS - 5q31.3 [CytoView hg38]
Mapping of homologs : NCBIHARS [Mapview hg19]  HARS [Mapview hg38]
OMIM142810   614504   616625   
Gene and transcription
Genbank (Entrez)AK000498 AK055917 AK094406 AK124831 AK225776
RefSeq transcript (Entrez)NM_001258040 NM_001258041 NM_001258042 NM_001289092 NM_001289093 NM_001289094 NM_002109
RefSeq genomic (Entrez)NC_000005 NC_018916 NG_032158 NT_029289 NW_004929324
Consensus coding sequences : CCDS (NCBI)HARS
Cluster EST : UnigeneHs.528050 [ NCBI ]
CGAP (NCI)Hs.528050
Alternative Splicing GalleryENSG00000170445
Gene ExpressionHARS [ NCBI-GEO ]   HARS [ EBI - ARRAY_EXPRESS ]   HARS [ SEEK ]   HARS [ MEM ]
Gene Expression Viewer (FireBrowse)HARS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3035
GTEX Portal (Tissue expression)HARS
Protein : pattern, domain, 3D structure
UniProt/SwissProtP12081   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP12081  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP12081
Splice isoforms : SwissVarP12081
Catalytic activity : Enzyme6.1.1.21 [ Enzyme-Expasy ]   6.1.1.216.1.1.21 [ IntEnz-EBI ]   6.1.1.21 [ BRENDA ]   6.1.1.21 [ KEGG ]   
PhosPhoSitePlusP12081
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_II (PS50862)    WHEP_TRS_1 (PS00762)    WHEP_TRS_2 (PS51185)   
Domains : Interpro (EBI)aa-tRNA-synth_II    Anticodon-bd    His-tRNA-ligase    HisRS/HisZ    S15_NS1_RNA-bd    WHEP-TRS_dom   
Domain families : Pfam (Sanger)HGTP_anticodon (PF03129)    WHEP-TRS (PF00458)   
Domain families : Pfam (NCBI)pfam03129    pfam00458   
Domain families : Smart (EMBL)WHEP-TRS (SM00991)  
Conserved Domain (NCBI)HARS
DMDM Disease mutations3035
Blocks (Seattle)HARS
PDB (SRS)1X59    2LW7    4G84    4G85    4PHC    4X5O   
PDB (PDBSum)1X59    2LW7    4G84    4G85    4PHC    4X5O   
PDB (IMB)1X59    2LW7    4G84    4G85    4PHC    4X5O   
PDB (RSDB)1X59    2LW7    4G84    4G85    4PHC    4X5O   
Structural Biology KnowledgeBase1X59    2LW7    4G84    4G85    4PHC    4X5O   
SCOP (Structural Classification of Proteins)1X59    2LW7    4G84    4G85    4PHC    4X5O   
CATH (Classification of proteins structures)1X59    2LW7    4G84    4G85    4PHC    4X5O   
SuperfamilyP12081
Human Protein AtlasENSG00000170445
Peptide AtlasP12081
HPRD00827
IPIIPI00021808   IPI00909075   IPI00940549   IPI00911023   IPI00965198   IPI00967106   IPI00910697   IPI00908779   IPI00967440   IPI00976939   
Protein Interaction databases
DIP (DOE-UCLA)P12081
IntAct (EBI)P12081
FunCoupENSG00000170445
BioGRIDHARS
STRING (EMBL)HARS
ZODIACHARS
Ontologies - Pathways
QuickGOP12081
Ontology : AmiGOhistidine-tRNA ligase activity  histidine-tRNA ligase activity  histidine-tRNA ligase activity  ATP binding  cytoplasm  mitochondrion  cytosol  translation  tRNA aminoacylation for protein translation  histidyl-tRNA aminoacylation  mitochondrial translation  
Ontology : EGO-EBIhistidine-tRNA ligase activity  histidine-tRNA ligase activity  histidine-tRNA ligase activity  ATP binding  cytoplasm  mitochondrion  cytosol  translation  tRNA aminoacylation for protein translation  histidyl-tRNA aminoacylation  mitochondrial translation  
Pathways : KEGGAminoacyl-tRNA biosynthesis   
NDEx NetworkHARS
Atlas of Cancer Signalling NetworkHARS
Wikipedia pathwaysHARS
Orthology - Evolution
OrthoDB3035
GeneTree (enSembl)ENSG00000170445
Phylogenetic Trees/Animal Genes : TreeFamHARS
HOVERGENP12081
HOGENOMP12081
Homologs : HomoloGeneHARS
Homology/Alignments : Family Browser (UCSC)HARS
Gene fusions - Rearrangements
Fusion : MitelmanHARS/CLINT1 [5q31.3/5q33.3]  
Fusion : MitelmanHARS/FAM53C [5q31.3/5q31.2]  [t(5;5)(q31;q31)]  
Fusion: TCGAHARS 5q31.3 CLINT1 5q33.3 BRCA
Fusion: TCGAHARS 5q31.3 FAM53C 5q31.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHARS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HARS
dbVarHARS
ClinVarHARS
1000_GenomesHARS 
Exome Variant ServerHARS
ExAC (Exome Aggregation Consortium)HARS (select the gene name)
Genetic variants : HAPMAP3035
Genomic Variants (DGV)HARS [DGVbeta]
DECIPHER (Syndromes)5:140053489-140071312  ENSG00000170445
CONAN: Copy Number AnalysisHARS 
Mutations
ICGC Data PortalHARS 
TCGA Data PortalHARS 
Broad Tumor PortalHARS
OASIS PortalHARS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHARS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHARS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Eye diseases - LOVD
BioMutasearch HARS
DgiDB (Drug Gene Interaction Database)HARS
DoCM (Curated mutations)HARS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HARS (select a term)
intoGenHARS
Cancer3DHARS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142810    614504    616625   
Orphanet19169   
MedgenHARS
Genetic Testing Registry HARS
NextProtP12081 [Medical]
TSGene3035
GENETestsHARS
Huge Navigator HARS [HugePedia]
snp3D : Map Gene to Disease3035
BioCentury BCIQHARS
ClinGenHARS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3035
Chemical/Pharm GKB GenePA29191
Clinical trialHARS
Miscellaneous
canSAR (ICR)HARS (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHARS
EVEXHARS
GoPubMedHARS
iHOPHARS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:08:36 CET 2017

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