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HASPIN (histone H3 associated protein kinase)

Identity

Alias_namesGSG2
germ cell associated 2 (haspin)
Other alias
HGNC (Hugo) HASPIN
LocusID (NCBI) 83903
Atlas_Id 80114
Location 17p13.2  [Link to chromosome band 17p13]
Location_base_pair Starts at 3723903 and ends at 3726698 bp from pter ( according to hg38-Dec_2013)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)HASPIN   19682
Cards
Entrez_Gene (NCBI)HASPIN  83903  histone H3 associated protein kinase
AliasesGSG2
GeneCards (Weizmann)HASPIN
Ensembl hg19 (Hinxton)ENSG00000177602 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177602 [Gene_View]  chr17:3723903-3726698 [Contig_View]  HASPIN [Vega]
ICGC DataPortalENSG00000177602
TCGA cBioPortalHASPIN
AceView (NCBI)HASPIN
Genatlas (Paris)HASPIN
WikiGenes83903
SOURCE (Princeton)HASPIN
Genetics Home Reference (NIH)HASPIN
Genomic and cartography
GoldenPath hg38 (UCSC)HASPIN  -     chr17:3723903-3726698 +  17p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HASPIN  -     17p13.2   [Description]    (hg19-Feb_2009)
EnsemblHASPIN - 17p13.2 [CytoView hg19]  HASPIN - 17p13.2 [CytoView hg38]
Mapping of homologs : NCBIHASPIN [Mapview hg19]  HASPIN [Mapview hg38]
OMIM609240   
Gene and transcription
Genbank (Entrez)AB039834 AF289865 AK056691 AK292715 AK310546
RefSeq transcript (Entrez)NM_031965
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HASPIN
Cluster EST : UnigeneHs.534059 [ NCBI ]
CGAP (NCI)Hs.534059
Alternative Splicing GalleryENSG00000177602
Gene ExpressionHASPIN [ NCBI-GEO ]   HASPIN [ EBI - ARRAY_EXPRESS ]   HASPIN [ SEEK ]   HASPIN [ MEM ]
Gene Expression Viewer (FireBrowse)HASPIN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)83903
GTEX Portal (Tissue expression)HASPIN
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TF76   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TF76  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TF76
Splice isoforms : SwissVarQ8TF76
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ8TF76
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)GSG2_C    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS   
Domain families : Pfam (Sanger)DUF3635 (PF12330)   
Domain families : Pfam (NCBI)pfam12330   
Domain families : Smart (EMBL)DUF3635 (SM01331)  S_TKc (SM00220)  
Conserved Domain (NCBI)HASPIN
DMDM Disease mutations83903
Blocks (Seattle)HASPIN
PDB (SRS)2VUW    2WB8    3DLZ    3E7V    3F2N    3FMD    3IQ7    4OUC    4QTC    5HTB    5HTC   
PDB (PDBSum)2VUW    2WB8    3DLZ    3E7V    3F2N    3FMD    3IQ7    4OUC    4QTC    5HTB    5HTC   
PDB (IMB)2VUW    2WB8    3DLZ    3E7V    3F2N    3FMD    3IQ7    4OUC    4QTC    5HTB    5HTC   
PDB (RSDB)2VUW    2WB8    3DLZ    3E7V    3F2N    3FMD    3IQ7    4OUC    4QTC    5HTB    5HTC   
Structural Biology KnowledgeBase2VUW    2WB8    3DLZ    3E7V    3F2N    3FMD    3IQ7    4OUC    4QTC    5HTB    5HTC   
SCOP (Structural Classification of Proteins)2VUW    2WB8    3DLZ    3E7V    3F2N    3FMD    3IQ7    4OUC    4QTC    5HTB    5HTC   
CATH (Classification of proteins structures)2VUW    2WB8    3DLZ    3E7V    3F2N    3FMD    3IQ7    4OUC    4QTC    5HTB    5HTC   
SuperfamilyQ8TF76
Human Protein AtlasENSG00000177602
Peptide AtlasQ8TF76
IPIIPI00397836   IPI00401554   
Protein Interaction databases
DIP (DOE-UCLA)Q8TF76
IntAct (EBI)Q8TF76
FunCoupENSG00000177602
BioGRIDHASPIN
STRING (EMBL)HASPIN
ZODIACHASPIN
Ontologies - Pathways
QuickGOQ8TF76
Ontology : AmiGOprotein kinase activity  protein binding  ATP binding  nucleus  chromosome  cytoplasm  centrosome  spindle  protein phosphorylation  mitotic sister chromatid cohesion  intracellular signal transduction  protein localization to chromosome, centromeric region  histone kinase activity (H3-T3 specific)  histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore  
Ontology : EGO-EBIprotein kinase activity  protein binding  ATP binding  nucleus  chromosome  cytoplasm  centrosome  spindle  protein phosphorylation  mitotic sister chromatid cohesion  intracellular signal transduction  protein localization to chromosome, centromeric region  histone kinase activity (H3-T3 specific)  histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore  
NDEx NetworkHASPIN
Atlas of Cancer Signalling NetworkHASPIN
Wikipedia pathwaysHASPIN
Orthology - Evolution
OrthoDB83903
GeneTree (enSembl)ENSG00000177602
Phylogenetic Trees/Animal Genes : TreeFamHASPIN
HOVERGENQ8TF76
HOGENOMQ8TF76
Homologs : HomoloGeneHASPIN
Homology/Alignments : Family Browser (UCSC)HASPIN
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHASPIN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HASPIN
dbVarHASPIN
ClinVarHASPIN
1000_GenomesHASPIN 
Exome Variant ServerHASPIN
ExAC (Exome Aggregation Consortium)HASPIN (select the gene name)
Genetic variants : HAPMAP83903
Genomic Variants (DGV)HASPIN [DGVbeta]
DECIPHERHASPIN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHASPIN 
Mutations
ICGC Data PortalHASPIN 
TCGA Data PortalHASPIN 
Broad Tumor PortalHASPIN
OASIS PortalHASPIN [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDHASPIN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HASPIN
DgiDB (Drug Gene Interaction Database)HASPIN
DoCM (Curated mutations)HASPIN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HASPIN (select a term)
intoGenHASPIN
Cancer3DHASPIN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609240   
Orphanet
MedgenHASPIN
Genetic Testing Registry HASPIN
NextProtQ8TF76 [Medical]
TSGene83903
GENETestsHASPIN
Target ValidationHASPIN
Huge Navigator HASPIN [HugePedia]
snp3D : Map Gene to Disease83903
BioCentury BCIQHASPIN
ClinGenHASPIN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD83903
Chemical/Pharm GKB GenePA134909705
Clinical trialHASPIN
Miscellaneous
canSAR (ICR)HASPIN (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHASPIN
EVEXHASPIN
GoPubMedHASPIN
iHOPHASPIN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:10:14 CEST 2017

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