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HBA2 (hemoglobin subunit alpha 2)

Identity

Alias_nameshemoglobin
Alias_symbol (synonym)HBA-T2
Other aliasHBH
HGNC (Hugo) HBA2
LocusID (NCBI) 3040
Atlas_Id 53728
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 172847 and ends at 173710 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HBA2 (16p13.3) / CSH2 (17q23.3)HBA2 (16p13.3) / HBA2 (16p13.3)HBA2 (16p13.3) / NFE2L1 (17q21.32)
HBA2 (16p13.3) / PEG10 (7q21.3)HBA2 (16p13.3) / USP34 (2p15)HBA2 (16p13.3) / ZNF268 (12q24.33)
MALAT1 (11q13.1) / HBA2 (16p13.3)PPY (17q21.31) / HBA2 (16p13.3)SCG5 (15q13.3) / HBA2 (16p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HBA2   4824
Cards
Entrez_Gene (NCBI)HBA2  3040  hemoglobin subunit alpha 2
AliasesHBA-T2; HBH
GeneCards (Weizmann)HBA2
Ensembl hg19 (Hinxton)ENSG00000188536 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188536 [Gene_View]  chr16:172847-173710 [Contig_View]  HBA2 [Vega]
ICGC DataPortalENSG00000188536
TCGA cBioPortalHBA2
AceView (NCBI)HBA2
Genatlas (Paris)HBA2
WikiGenes3040
SOURCE (Princeton)HBA2
Genetics Home Reference (NIH)HBA2
Genomic and cartography
GoldenPath hg38 (UCSC)HBA2  -     chr16:172847-173710 +  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HBA2  -     16p13.3   [Description]    (hg19-Feb_2009)
EnsemblHBA2 - 16p13.3 [CytoView hg19]  HBA2 - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBIHBA2 [Mapview hg19]  HBA2 [Mapview hg38]
OMIM140700   141850   604131   613978   
Gene and transcription
Genbank (Entrez)AF097635 AF105974 AF147332 AF281258 AF349571
RefSeq transcript (Entrez)NM_000517
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HBA2
Cluster EST : UnigeneHs.654744 [ NCBI ]
CGAP (NCI)Hs.654744
Alternative Splicing GalleryENSG00000188536
Gene ExpressionHBA2 [ NCBI-GEO ]   HBA2 [ EBI - ARRAY_EXPRESS ]   HBA2 [ SEEK ]   HBA2 [ MEM ]
Gene Expression Viewer (FireBrowse)HBA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3040
GTEX Portal (Tissue expression)HBA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP69905   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP69905  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP69905
Splice isoforms : SwissVarP69905
PhosPhoSitePlusP69905
Domaine pattern : Prosite (Expaxy)GLOBIN (PS01033)   
Domains : Interpro (EBI)Globin    Globin-like    Globin/Proto    Haemoglobin_a-typ    Haemoglobin_pi   
Domain families : Pfam (Sanger)Globin (PF00042)   
Domain families : Pfam (NCBI)pfam00042   
Conserved Domain (NCBI)HBA2
DMDM Disease mutations3040
Blocks (Seattle)HBA2
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP69905
Human Protein AtlasENSG00000188536
Peptide AtlasP69905
HPRD00785
Protein Interaction databases
DIP (DOE-UCLA)P69905
IntAct (EBI)P69905
FunCoupENSG00000188536
BioGRIDHBA2
STRING (EMBL)HBA2
ZODIACHBA2
Ontologies - Pathways
QuickGOP69905
Ontology : AmiGOperoxidase activity  oxygen transporter activity  iron ion binding  protein binding  extracellular region  cytosol  hemoglobin complex  hemoglobin complex  receptor-mediated endocytosis  positive regulation of cell death  oxygen transport  bicarbonate transport  membrane  oxygen binding  heme binding  cytosolic small ribosomal subunit  haptoglobin binding  haptoglobin-hemoglobin complex  response to hydrogen peroxide  hydrogen peroxide catabolic process  protein heterooligomerization  extracellular exosome  endocytic vesicle lumen  blood microparticle  cellular oxidant detoxification  
Ontology : EGO-EBIperoxidase activity  oxygen transporter activity  iron ion binding  protein binding  extracellular region  cytosol  hemoglobin complex  hemoglobin complex  receptor-mediated endocytosis  positive regulation of cell death  oxygen transport  bicarbonate transport  membrane  oxygen binding  heme binding  cytosolic small ribosomal subunit  haptoglobin binding  haptoglobin-hemoglobin complex  response to hydrogen peroxide  hydrogen peroxide catabolic process  protein heterooligomerization  extracellular exosome  endocytic vesicle lumen  blood microparticle  cellular oxidant detoxification  
Pathways : BIOCARTAHemoglobin's Chaperone [Genes]   
Pathways : KEGGAfrican trypanosomiasis    Malaria   
NDEx NetworkHBA2
Atlas of Cancer Signalling NetworkHBA2
Wikipedia pathwaysHBA2
Orthology - Evolution
OrthoDB3040
GeneTree (enSembl)ENSG00000188536
Phylogenetic Trees/Animal Genes : TreeFamHBA2
HOVERGENP69905
HOGENOMP69905
Homologs : HomoloGeneHBA2
Homology/Alignments : Family Browser (UCSC)HBA2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHBA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HBA2
dbVarHBA2
ClinVarHBA2
1000_GenomesHBA2 
Exome Variant ServerHBA2
ExAC (Exome Aggregation Consortium)HBA2 (select the gene name)
Genetic variants : HAPMAP3040
Genomic Variants (DGV)HBA2 [DGVbeta]
DECIPHERHBA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHBA2 
Mutations
ICGC Data PortalHBA2 
TCGA Data PortalHBA2 
Broad Tumor PortalHBA2
OASIS PortalHBA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHBA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHBA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)The Globin Gene Server
BioMutasearch HBA2
DgiDB (Drug Gene Interaction Database)HBA2
DoCM (Curated mutations)HBA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HBA2 (select a term)
intoGenHBA2
Cancer3DHBA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM140700    141850    604131    613978   
Orphanet17507    21963    12449    13808   
MedgenHBA2
Genetic Testing Registry HBA2
NextProtP69905 [Medical]
TSGene3040
GENETestsHBA2
Target ValidationHBA2
Huge Navigator HBA2 [HugePedia]
snp3D : Map Gene to Disease3040
BioCentury BCIQHBA2
ClinGenHBA2 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3040
Chemical/Pharm GKB GenePA29199
Clinical trialHBA2
Miscellaneous
canSAR (ICR)HBA2 (select the gene name)
Probes
Litterature
PubMed265 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHBA2
EVEXHBA2
GoPubMedHBA2
iHOPHBA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:36:26 CEST 2017

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