Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HBEGF (heparin binding EGF like growth factor)

Identity

Alias (NCBI)DTR
DTS
DTSF
HEGFL
HGNC (Hugo) HBEGF
HGNC Alias nameDiphtheria toxin receptor (heparin-binding EGF-like growth factor)
 heparin-binding epidermal growth factor
HGNC Previous nameHEGFL
 DTS
 DTR
HGNC Previous namediphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor)
 heparin-binding EGF-like growth factor
LocusID (NCBI) 1839
Atlas_Id 40369
Location 5q31.3  [Link to chromosome band 5q31]
Location_base_pair Starts at 140332843 and ends at 140346603 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)HBEGF   3059
Cards
Entrez_Gene (NCBI)HBEGF    heparin binding EGF like growth factor
AliasesDTR; DTS; DTSF; HEGFL
GeneCards (Weizmann)HBEGF
Ensembl hg19 (Hinxton)ENSG00000113070 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113070 [Gene_View]  ENSG00000113070 [Sequence]  chr5:140332843-140346603 [Contig_View]  HBEGF [Vega]
ICGC DataPortalENSG00000113070
TCGA cBioPortalHBEGF
AceView (NCBI)HBEGF
Genatlas (Paris)HBEGF
SOURCE (Princeton)HBEGF
Genetics Home Reference (NIH)HBEGF
Genomic and cartography
GoldenPath hg38 (UCSC)HBEGF  -     chr5:140332843-140346603 -  5q31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HBEGF  -     5q31.3   [Description]    (hg19-Feb_2009)
GoldenPathHBEGF - 5q31.3 [CytoView hg19]  HBEGF - 5q31.3 [CytoView hg38]
ImmunoBaseENSG00000113070
Genome Data Viewer NCBIHBEGF [Mapview hg19]  
OMIM126150   
Gene and transcription
Genbank (Entrez)AK222688 AK307310 AK313202 BC033097 D55114
RefSeq transcript (Entrez)NM_001945
Consensus coding sequences : CCDS (NCBI)HBEGF
Gene ExpressionHBEGF [ NCBI-GEO ]   HBEGF [ EBI - ARRAY_EXPRESS ]   HBEGF [ SEEK ]   HBEGF [ MEM ]
Gene Expression Viewer (FireBrowse)HBEGF [ Firebrowse - Broad ]
GenevisibleExpression of HBEGF in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1839
GTEX Portal (Tissue expression)HBEGF
Human Protein AtlasENSG00000113070-HBEGF [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99075   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99075  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99075
PhosPhoSitePlusQ99075
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)   
Domains : Interpro (EBI)EGF-like_dom    EGF_rcpt_ligand   
Domain families : Pfam (Sanger)EGF (PF00008)   
Domain families : Pfam (NCBI)pfam00008   
Conserved Domain (NCBI)HBEGF
PDB (RSDB)1XDT    2M8S   
PDB Europe1XDT    2M8S   
PDB (PDBSum)1XDT    2M8S   
PDB (IMB)1XDT    2M8S   
Structural Biology KnowledgeBase1XDT    2M8S   
SCOP (Structural Classification of Proteins)1XDT    2M8S   
CATH (Classification of proteins structures)1XDT    2M8S   
SuperfamilyQ99075
AlphaFold pdb e-kbQ99075   
Human Protein Atlas [tissue]ENSG00000113070-HBEGF [tissue]
HPRD00526
Protein Interaction databases
DIP (DOE-UCLA)Q99075
IntAct (EBI)Q99075
BioGRIDHBEGF
STRING (EMBL)HBEGF
ZODIACHBEGF
Ontologies - Pathways
QuickGOQ99075
Ontology : AmiGOMAPK cascade  epidermal growth factor receptor binding  protein binding  extracellular region  extracellular space  extracellular space  extracellular space  extracellular space  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  integral component of plasma membrane  signal transduction  epidermal growth factor receptor signaling pathway  epidermal growth factor receptor signaling pathway  epidermal growth factor receptor signaling pathway  muscle organ development  regulation of heart contraction  growth factor activity  growth factor activity  heparin binding  heparin binding  positive regulation of cell population proliferation  cell surface  cell surface  positive regulation of cell growth  positive regulation of cell migration  endocytic vesicle membrane  clathrin-coated endocytic vesicle membrane  wound healing, spreading of epidermal cells  ERBB2 signaling pathway  negative regulation of epidermal growth factor receptor signaling pathway  positive regulation of epidermal growth factor-activated receptor activity  positive regulation of smooth muscle cell proliferation  negative regulation of elastin biosynthetic process  positive regulation of keratinocyte migration  positive regulation of protein kinase B signaling  positive regulation of protein kinase B signaling  cell chemotaxis  membrane organization  positive regulation of wound healing  regulation of cell motility  
Ontology : EGO-EBIMAPK cascade  epidermal growth factor receptor binding  protein binding  extracellular region  extracellular space  extracellular space  extracellular space  extracellular space  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  integral component of plasma membrane  signal transduction  epidermal growth factor receptor signaling pathway  epidermal growth factor receptor signaling pathway  epidermal growth factor receptor signaling pathway  muscle organ development  regulation of heart contraction  growth factor activity  growth factor activity  heparin binding  heparin binding  positive regulation of cell population proliferation  cell surface  cell surface  positive regulation of cell growth  positive regulation of cell migration  endocytic vesicle membrane  clathrin-coated endocytic vesicle membrane  wound healing, spreading of epidermal cells  ERBB2 signaling pathway  negative regulation of epidermal growth factor receptor signaling pathway  positive regulation of epidermal growth factor-activated receptor activity  positive regulation of smooth muscle cell proliferation  negative regulation of elastin biosynthetic process  positive regulation of keratinocyte migration  positive regulation of protein kinase B signaling  positive regulation of protein kinase B signaling  cell chemotaxis  membrane organization  positive regulation of wound healing  regulation of cell motility  
Pathways : BIOCARTANFAT and Hypertrophy of the heart (Transcription in the broken heart) [Genes]   
Pathways : KEGGErbB signaling pathway    GnRH signaling pathway    Estrogen signaling pathway    Epithelial cell signaling in Helicobacter pylori infection    Proteoglycans in cancer   
NDEx NetworkHBEGF
Atlas of Cancer Signalling NetworkHBEGF
Wikipedia pathwaysHBEGF
Orthology - Evolution
OrthoDB1839
GeneTree (enSembl)ENSG00000113070
Phylogenetic Trees/Animal Genes : TreeFamHBEGF
Homologs : HomoloGeneHBEGF
Homology/Alignments : Family Browser (UCSC)HBEGF
Gene fusions - Rearrangements
Fusion : QuiverHBEGF
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHBEGF [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HBEGF
dbVarHBEGF
ClinVarHBEGF
MonarchHBEGF
1000_GenomesHBEGF 
Exome Variant ServerHBEGF
GNOMAD BrowserENSG00000113070
Varsome BrowserHBEGF
ACMGHBEGF variants
VarityQ99075
Genomic Variants (DGV)HBEGF [DGVbeta]
DECIPHERHBEGF [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHBEGF 
Mutations
ICGC Data PortalHBEGF 
TCGA Data PortalHBEGF 
Broad Tumor PortalHBEGF
OASIS PortalHBEGF [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHBEGF  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHBEGF
Mutations and Diseases : HGMDHBEGF
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHBEGF
DgiDB (Drug Gene Interaction Database)HBEGF
DoCM (Curated mutations)HBEGF
CIViC (Clinical Interpretations of Variants in Cancer)HBEGF
Cancer3DHBEGF
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM126150   
Orphanet
DisGeNETHBEGF
MedgenHBEGF
Genetic Testing Registry HBEGF
NextProtQ99075 [Medical]
GENETestsHBEGF
Target ValidationHBEGF
Huge Navigator HBEGF [HugePedia]
ClinGenHBEGF
Clinical trials, drugs, therapy
MyCancerGenomeHBEGF
Protein Interactions : CTDHBEGF
Pharm GKB GenePA27513
Pharm GKB PathwaysPA162356267   
PharosQ99075
Clinical trialHBEGF
Miscellaneous
canSAR (ICR)HBEGF
HarmonizomeHBEGF
DataMed IndexHBEGF
Probes
Litterature
PubMed198 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHBEGF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:12:05 CEST 2021

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