Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HBEGF (heparin binding EGF like growth factor)

Identity

Alias_namesHEGFL
DTS
DTR
diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor)
heparin-binding EGF-like growth factor
Other aliasDTSF
HGNC (Hugo) HBEGF
LocusID (NCBI) 1839
Atlas_Id 40369
Location 5q31.3  [Link to chromosome band 5q31]
Location_base_pair Starts at 139712428 and ends at 139726188 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HBEGF   3059
Cards
Entrez_Gene (NCBI)HBEGF  1839  heparin binding EGF like growth factor
AliasesDTR; DTS; DTSF; HEGFL
GeneCards (Weizmann)HBEGF
Ensembl hg19 (Hinxton)ENSG00000113070 [Gene_View]  chr5:139712428-139726188 [Contig_View]  HBEGF [Vega]
Ensembl hg38 (Hinxton)ENSG00000113070 [Gene_View]  chr5:139712428-139726188 [Contig_View]  HBEGF [Vega]
ICGC DataPortalENSG00000113070
TCGA cBioPortalHBEGF
AceView (NCBI)HBEGF
Genatlas (Paris)HBEGF
WikiGenes1839
SOURCE (Princeton)HBEGF
Genetics Home Reference (NIH)HBEGF
Genomic and cartography
GoldenPath hg19 (UCSC)HBEGF  -     chr5:139712428-139726188 -  5q31.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HBEGF  -     5q31.3   [Description]    (hg38-Dec_2013)
EnsemblHBEGF - 5q31.3 [CytoView hg19]  HBEGF - 5q31.3 [CytoView hg38]
Mapping of homologs : NCBIHBEGF [Mapview hg19]  HBEGF [Mapview hg38]
OMIM126150   
Gene and transcription
Genbank (Entrez)AK222688 AK307310 AK313202 BC033097 D55114
RefSeq transcript (Entrez)NM_001945
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_029289 NW_004929324
Consensus coding sequences : CCDS (NCBI)HBEGF
Cluster EST : UnigeneHs.592942 [ NCBI ]
CGAP (NCI)Hs.592942
Alternative Splicing GalleryENSG00000113070
Gene ExpressionHBEGF [ NCBI-GEO ]   HBEGF [ EBI - ARRAY_EXPRESS ]   HBEGF [ SEEK ]   HBEGF [ MEM ]
Gene Expression Viewer (FireBrowse)HBEGF [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1839
GTEX Portal (Tissue expression)HBEGF
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99075   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99075  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99075
Splice isoforms : SwissVarQ99075
PhosPhoSitePlusQ99075
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)   
Domains : Interpro (EBI)EGF-like_CS    EGF-like_dom    EGF_rcpt_ligand   
Domain families : Pfam (Sanger)EGF (PF00008)   
Domain families : Pfam (NCBI)pfam00008   
Domain families : Smart (EMBL)EGF (SM00181)  
Conserved Domain (NCBI)HBEGF
DMDM Disease mutations1839
Blocks (Seattle)HBEGF
PDB (SRS)1XDT    2M8S   
PDB (PDBSum)1XDT    2M8S   
PDB (IMB)1XDT    2M8S   
PDB (RSDB)1XDT    2M8S   
Structural Biology KnowledgeBase1XDT    2M8S   
SCOP (Structural Classification of Proteins)1XDT    2M8S   
CATH (Classification of proteins structures)1XDT    2M8S   
SuperfamilyQ99075
Human Protein AtlasENSG00000113070
Peptide AtlasQ99075
HPRD00526
IPIIPI00012948   
Protein Interaction databases
DIP (DOE-UCLA)Q99075
IntAct (EBI)Q99075
FunCoupENSG00000113070
BioGRIDHBEGF
STRING (EMBL)HBEGF
ZODIACHBEGF
Ontologies - Pathways
QuickGOQ99075
Ontology : AmiGOMAPK cascade  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  epidermal growth factor receptor binding  extracellular region  extracellular space  extracellular space  extracellular space  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  signal transduction  epidermal growth factor receptor signaling pathway  muscle organ development  regulation of heart contraction  growth factor activity  heparin binding  positive regulation of cell proliferation  cell surface  cell surface  regulation of phosphatidylinositol 3-kinase signaling  peptidyl-tyrosine phosphorylation  positive regulation of cell growth  positive regulation of cell migration  endocytic vesicle membrane  clathrin-coated endocytic vesicle membrane  wound healing, spreading of epidermal cells  ERBB2 signaling pathway  positive regulation of GTPase activity  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  positive regulation of smooth muscle cell proliferation  negative regulation of elastin biosynthetic process  positive regulation of keratinocyte migration  positive regulation of protein kinase B signaling  cell chemotaxis  positive regulation of wound healing  regulation of cell motility  
Ontology : EGO-EBIMAPK cascade  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  epidermal growth factor receptor binding  extracellular region  extracellular space  extracellular space  extracellular space  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  signal transduction  epidermal growth factor receptor signaling pathway  muscle organ development  regulation of heart contraction  growth factor activity  heparin binding  positive regulation of cell proliferation  cell surface  cell surface  regulation of phosphatidylinositol 3-kinase signaling  peptidyl-tyrosine phosphorylation  positive regulation of cell growth  positive regulation of cell migration  endocytic vesicle membrane  clathrin-coated endocytic vesicle membrane  wound healing, spreading of epidermal cells  ERBB2 signaling pathway  positive regulation of GTPase activity  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  positive regulation of smooth muscle cell proliferation  negative regulation of elastin biosynthetic process  positive regulation of keratinocyte migration  positive regulation of protein kinase B signaling  cell chemotaxis  positive regulation of wound healing  regulation of cell motility  
Pathways : BIOCARTANFAT and Hypertrophy of the heart (Transcription in the broken heart) [Genes]   
Pathways : KEGGErbB signaling pathway    GnRH signaling pathway    Estrogen signaling pathway    Epithelial cell signaling in Helicobacter pylori infection    Proteoglycans in cancer   
NDEx NetworkHBEGF
Atlas of Cancer Signalling NetworkHBEGF
Wikipedia pathwaysHBEGF
Orthology - Evolution
OrthoDB1839
GeneTree (enSembl)ENSG00000113070
Phylogenetic Trees/Animal Genes : TreeFamHBEGF
HOVERGENQ99075
HOGENOMQ99075
Homologs : HomoloGeneHBEGF
Homology/Alignments : Family Browser (UCSC)HBEGF
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHBEGF [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HBEGF
dbVarHBEGF
ClinVarHBEGF
1000_GenomesHBEGF 
Exome Variant ServerHBEGF
ExAC (Exome Aggregation Consortium)HBEGF (select the gene name)
Genetic variants : HAPMAP1839
Genomic Variants (DGV)HBEGF [DGVbeta]
DECIPHER (Syndromes)5:139712428-139726188  ENSG00000113070
CONAN: Copy Number AnalysisHBEGF 
Mutations
ICGC Data PortalHBEGF 
TCGA Data PortalHBEGF 
Broad Tumor PortalHBEGF
OASIS PortalHBEGF [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHBEGF  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHBEGF
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HBEGF
DgiDB (Drug Gene Interaction Database)HBEGF
DoCM (Curated mutations)HBEGF (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HBEGF (select a term)
intoGenHBEGF
Cancer3DHBEGF(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM126150   
Orphanet
MedgenHBEGF
Genetic Testing Registry HBEGF
NextProtQ99075 [Medical]
TSGene1839
GENETestsHBEGF
Huge Navigator HBEGF [HugePedia]
snp3D : Map Gene to Disease1839
BioCentury BCIQHBEGF
ClinGenHBEGF
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1839
Chemical/Pharm GKB GenePA27513
Clinical trialHBEGF
Miscellaneous
canSAR (ICR)HBEGF (select the gene name)
Probes
Litterature
PubMed163 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHBEGF
EVEXHBEGF
GoPubMedHBEGF
iHOPHBEGF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:08:39 CET 2017

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