Identity
HGNC
LOCATION
12q24.31
LOCUSID
ALIAS
GPR109A,HCA2,HM74a,HM74b,NIACR1,PUMAG,Puma-g
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 338442
MIM: 609163
HGNC: 24827
Ensembl: ENSG00000182782
Variants:
dbSNP: 338442
ClinVar: 338442
TCGA: ENSG00000182782
COSMIC: HCAR2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000182782 | ENST00000328880 | Q8TDS4 |
| ENSG00000182782 | ENST00000328880 | A0A4Y1JWQ0 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA450617 | niacin | Chemical | VariantAnnotation | not associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37578011 | 2023 | Ebola Virus Infection Induces HCAR2 Expression Leading to Cell Death. | 0 |
| 37932263 | 2023 | Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2. | 3 |
| 37933650 | 2023 | [GPR109A partly mediates inhibitory effects of β-hydroxybutyric acid on lung adenocarcinoma cell proliferation, migration and invasion]. | 0 |
| 38007572 | 2023 | Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a. | 3 |
| 37578011 | 2023 | Ebola Virus Infection Induces HCAR2 Expression Leading to Cell Death. | 0 |
| 37932263 | 2023 | Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2. | 3 |
| 37933650 | 2023 | [GPR109A partly mediates inhibitory effects of β-hydroxybutyric acid on lung adenocarcinoma cell proliferation, migration and invasion]. | 0 |
| 38007572 | 2023 | Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a. | 3 |
| 34777363 | 2021 | GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics. | 6 |
| 34852802 | 2021 | Rare and potentially pathogenic variants in hydroxycarboxylic acid receptor genes identified in breast cancer cases. | 2 |
| 34777363 | 2021 | GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics. | 6 |
| 34852802 | 2021 | Rare and potentially pathogenic variants in hydroxycarboxylic acid receptor genes identified in breast cancer cases. | 2 |
| 31734354 | 2020 | Clostridium butyricum, a butyrate-producing probiotic, inhibits intestinal tumor development through modulating Wnt signaling and gut microbiota. | 176 |
| 31858105 | 2020 | Niacin Ameliorates Hepatic Steatosis by Inhibiting De Novo Lipogenesis Via a GPR109A-Mediated PKC-ERK1/2-AMPK Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet. | 16 |
| 31734354 | 2020 | Clostridium butyricum, a butyrate-producing probiotic, inhibits intestinal tumor development through modulating Wnt signaling and gut microbiota. | 176 |
Citation
Dessen P
HCAR2 (hydroxycarboxylic acid receptor 2)
Atlas Genet Cytogenet Oncol Haematol. 2011-10-01
Online version: http://atlasgeneticsoncology.org/gene/52400/hcar2
