Atlas of Genetics and Cytogenetics in Oncology and Haematology

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HCAR3 (hydroxycarboxylic acid receptor 3)

Identity

Alias_namesGPR109B
G protein-coupled receptor 109B
Alias_symbol (synonym)HCA3
HM74
Other aliasPUMAG
Puma-g
HGNC (Hugo) HCAR3
LocusID (NCBI) 8843
Atlas_Id 52451
Location 12q24.31  [Link to chromosome band 12q24]
Location_base_pair Starts at 122714756 and ends at 122716811 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)HCAR3   16824
Cards
Entrez_Gene (NCBI)HCAR3  8843  hydroxycarboxylic acid receptor 3
AliasesGPR109B; HCA3; HM74; PUMAG; 
Puma-g
GeneCards (Weizmann)HCAR3
Ensembl hg19 (Hinxton)ENSG00000255398 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000255398 [Gene_View]  ENSG00000255398 [Sequence]  chr12:122714756-122716811 [Contig_View]  HCAR3 [Vega]
ICGC DataPortalENSG00000255398
TCGA cBioPortalHCAR3
AceView (NCBI)HCAR3
Genatlas (Paris)HCAR3
WikiGenes8843
SOURCE (Princeton)HCAR3
Genetics Home Reference (NIH)HCAR3
Genomic and cartography
GoldenPath hg38 (UCSC)HCAR3  -     chr12:122714756-122716811 -  12q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HCAR3  -     12q24.31   [Description]    (hg19-Feb_2009)
GoldenPathHCAR3 - 12q24.31 [CytoView hg19]  HCAR3 - 12q24.31 [CytoView hg38]
ImmunoBaseENSG00000255398
Mapping of homologs : NCBIHCAR3 [Mapview hg19]  HCAR3 [Mapview hg38]
OMIM606039   
Gene and transcription
Genbank (Entrez)AK290930 AK313212 BC038955 BC047891 BI908162
RefSeq transcript (Entrez)NM_006018
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HCAR3
Alternative Splicing GalleryENSG00000255398
Gene ExpressionHCAR3 [ NCBI-GEO ]   HCAR3 [ EBI - ARRAY_EXPRESS ]   HCAR3 [ SEEK ]   HCAR3 [ MEM ]
Gene Expression Viewer (FireBrowse)HCAR3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8843
GTEX Portal (Tissue expression)HCAR3
Human Protein AtlasENSG00000255398-HCAR3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49019   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49019  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49019
Splice isoforms : SwissVarP49019
PhosPhoSitePlusP49019
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    HCAR2/3_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)HCAR3
DMDM Disease mutations8843
Blocks (Seattle)HCAR3
SuperfamilyP49019
Human Protein Atlas [tissue]ENSG00000255398-HCAR3 [tissue]
Peptide AtlasP49019
HPRD06917
IPIIPI00025628   
Protein Interaction databases
DIP (DOE-UCLA)P49019
IntAct (EBI)P49019
FunCoupENSG00000255398
BioGRIDHCAR3
STRING (EMBL)HCAR3
ZODIACHCAR3
Ontologies - Pathways
QuickGOP49019
Ontology : AmiGOG protein-coupled receptor activity  plasma membrane  integral component of plasma membrane  G protein-coupled receptor signaling pathway  cell junction  
Ontology : EGO-EBIG protein-coupled receptor activity  plasma membrane  integral component of plasma membrane  G protein-coupled receptor signaling pathway  cell junction  
NDEx NetworkHCAR3
Atlas of Cancer Signalling NetworkHCAR3
Wikipedia pathwaysHCAR3
Orthology - Evolution
OrthoDB8843
GeneTree (enSembl)ENSG00000255398
Phylogenetic Trees/Animal Genes : TreeFamHCAR3
HOGENOMP49019
Homologs : HomoloGeneHCAR3
Homology/Alignments : Family Browser (UCSC)HCAR3
Gene fusions - Rearrangements
Fusion : QuiverHCAR3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHCAR3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HCAR3
dbVarHCAR3
ClinVarHCAR3
1000_GenomesHCAR3 
Exome Variant ServerHCAR3
ExAC (Exome Aggregation Consortium)ENSG00000255398
GNOMAD BrowserENSG00000255398
Varsome BrowserHCAR3
Genetic variants : HAPMAP8843
Genomic Variants (DGV)HCAR3 [DGVbeta]
DECIPHERHCAR3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHCAR3 
Mutations
ICGC Data PortalHCAR3 
TCGA Data PortalHCAR3 
Broad Tumor PortalHCAR3
OASIS PortalHCAR3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHCAR3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHCAR3
Mutations and Diseases : HGMDHCAR3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HCAR3
DgiDB (Drug Gene Interaction Database)HCAR3
DoCM (Curated mutations)HCAR3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HCAR3 (select a term)
intoGenHCAR3
Cancer3DHCAR3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606039   
Orphanet
DisGeNETHCAR3
MedgenHCAR3
Genetic Testing Registry HCAR3
NextProtP49019 [Medical]
TSGene8843
GENETestsHCAR3
Target ValidationHCAR3
Huge Navigator HCAR3 [HugePedia]
snp3D : Map Gene to Disease8843
BioCentury BCIQHCAR3
ClinGenHCAR3
Clinical trials, drugs, therapy
Protein Interactions : CTD8843
Pharm GKB GenePA165512827
Clinical trialHCAR3
Miscellaneous
canSAR (ICR)HCAR3 (select the gene name)
HarmonizomeHCAR3
DataMed IndexHCAR3
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHCAR3
EVEXHCAR3
GoPubMedHCAR3
iHOPHCAR3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Jun 30 20:17:56 CEST 2020
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