HCLS1 (hematopoietic cell-specific Lyn substrate 1)

2007-02-01  

Identity

HGNC
LOCATION
3q13.33
LOCUSID
ALIAS
CTTNL,HS1,lckBP1,p75
FUSION GENES

Other Information

Locus ID:

NCBI: 3059
MIM: 601306
HGNC: 4844
Ensembl: ENSG00000180353

Variants:

dbSNP: 3059
ClinVar: 3059
TCGA: ENSG00000180353
COSMIC: HCLS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180353ENST00000314583P14317
ENSG00000180353ENST00000428394E7EVW7
ENSG00000180353ENST00000464274F8WDD5
ENSG00000180353ENST00000495491P14317
ENSG00000180353ENST00000497391F8WEZ6

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Pathogenic Escherichia coli infectionKEGGko05130
Tight junctionKEGGhsa04530
Pathogenic Escherichia coli infectionKEGGhsa05130
ShigellosisKEGGhsa05131
Bacterial invasion of epithelial cellsKEGGko05100
Bacterial invasion of epithelial cellsKEGGhsa05100
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
119880742002Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells.55
205307932010HS1 has a central role in the trafficking and homing of leukemic B cells.28
230011822012Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis.27
161576032005The coiled-coil domain is required for HS1 to bind to F-actin and activate Arp2/3 complex.18
157952332005Thrombin-induced tyrosine phosphorylation of HS1 in human platelets is sequentially catalyzed by Syk and Lyn tyrosine kinases and associated with the cellular migration of the protein.14
226790232012The actin regulatory protein HS1 interacts with Arp2/3 and mediates efficient neutrophil chemotaxis.13
227681612012HS1, a Lyn kinase substrate, is abnormally expressed in B-chronic lymphocytic leukemia and correlates with response to fludarabine-based regimen.12
284655292017Wnt5a induces ROR1 to complex with HS1 to enhance migration of chronic lymphocytic leukemia cells.12
116890062001Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis.9
223330382012High expression of hematopoietic cell specific Lyn substrate-1 (HS1) predicts poor survival of B-cell chronic lymphocytic leukemia patients.8

Citation

Dessen P

HCLS1 (hematopoietic cell-specific Lyn substrate 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46153/hcls1