Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HCN2 (hyperpolarization activated cyclic nucleotide gated potassium channel 2)

Identity

Alias_namesBCNG2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
Alias_symbol (synonym)BCNG-2
HAC-1
Other alias
HGNC (Hugo) HCN2
LocusID (NCBI) 610
Atlas_Id 64209
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 589893 and ends at 617159 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
HCN2 (19p13.3) / BSG (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HCN2   4846
Cards
Entrez_Gene (NCBI)HCN2  610  hyperpolarization activated cyclic nucleotide gated potassium channel 2
AliasesBCNG-2; BCNG2; HAC-1
GeneCards (Weizmann)HCN2
Ensembl hg19 (Hinxton)ENSG00000099822 [Gene_View]  chr19:589893-617159 [Contig_View]  HCN2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000099822 [Gene_View]  chr19:589893-617159 [Contig_View]  HCN2 [Vega]
ICGC DataPortalENSG00000099822
TCGA cBioPortalHCN2
AceView (NCBI)HCN2
Genatlas (Paris)HCN2
WikiGenes610
SOURCE (Princeton)HCN2
Genetics Home Reference (NIH)HCN2
Genomic and cartography
GoldenPath hg19 (UCSC)HCN2  -     chr19:589893-617159 +  19p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HCN2  -     19p13.3   [Description]    (hg38-Dec_2013)
EnsemblHCN2 - 19p13.3 [CytoView hg19]  HCN2 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIHCN2 [Mapview hg19]  HCN2 [Mapview hg38]
OMIM602781   
Gene and transcription
Genbank (Entrez)AF064877 AF065164 AJ012582 BC039619 BC118001
RefSeq transcript (Entrez)NM_001194
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011295 NW_004929412
Consensus coding sequences : CCDS (NCBI)HCN2
Cluster EST : UnigeneHs.124161 [ NCBI ]
CGAP (NCI)Hs.124161
Alternative Splicing GalleryENSG00000099822
Gene ExpressionHCN2 [ NCBI-GEO ]   HCN2 [ EBI - ARRAY_EXPRESS ]   HCN2 [ SEEK ]   HCN2 [ MEM ]
Gene Expression Viewer (FireBrowse)HCN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)610
GTEX Portal (Tissue expression)HCN2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UL51   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UL51  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UL51
Splice isoforms : SwissVarQ9UL51
PhosPhoSitePlusQ9UL51
Domaine pattern : Prosite (Expaxy)CNMP_BINDING_1 (PS00888)    CNMP_BINDING_3 (PS50042)   
Domains : Interpro (EBI)cNMP-bd-like    cNMP-bd_CS    cNMP-bd_dom    Ion_trans_dom    Ion_trans_N    K_chnl_volt-dep_EAG/ELK/ERG    RmlC-like_jellyroll   
Domain families : Pfam (Sanger)cNMP_binding (PF00027)    Ion_trans (PF00520)    Ion_trans_N (PF08412)   
Domain families : Pfam (NCBI)pfam00027    pfam00520    pfam08412   
Domain families : Smart (EMBL)cNMP (SM00100)  
Conserved Domain (NCBI)HCN2
DMDM Disease mutations610
Blocks (Seattle)HCN2
PDB (SRS)2MPF    3U10   
PDB (PDBSum)2MPF    3U10   
PDB (IMB)2MPF    3U10   
PDB (RSDB)2MPF    3U10   
Structural Biology KnowledgeBase2MPF    3U10   
SCOP (Structural Classification of Proteins)2MPF    3U10   
CATH (Classification of proteins structures)2MPF    3U10   
SuperfamilyQ9UL51
Human Protein AtlasENSG00000099822
Peptide AtlasQ9UL51
HPRD07213
IPIIPI00218946   
Protein Interaction databases
DIP (DOE-UCLA)Q9UL51
IntAct (EBI)Q9UL51
FunCoupENSG00000099822
BioGRIDHCN2
STRING (EMBL)HCN2
ZODIACHCN2
Ontologies - Pathways
QuickGOQ9UL51
Ontology : AmiGOintracellular cAMP activated cation channel activity  voltage-gated sodium channel activity  voltage-gated potassium channel activity  voltage-gated potassium channel activity  plasma membrane  plasma membrane  integral component of plasma membrane  cell-cell signaling  synaptic transmission  voltage-gated potassium channel complex  cAMP binding  regulation of ion transmembrane transport  sodium ion transmembrane transport  regulation of membrane potential  identical protein binding  cellular response to cAMP  cellular response to cGMP  potassium ion transmembrane transport  potassium ion transmembrane transport  
Ontology : EGO-EBIintracellular cAMP activated cation channel activity  voltage-gated sodium channel activity  voltage-gated potassium channel activity  voltage-gated potassium channel activity  plasma membrane  plasma membrane  integral component of plasma membrane  cell-cell signaling  synaptic transmission  voltage-gated potassium channel complex  cAMP binding  regulation of ion transmembrane transport  sodium ion transmembrane transport  regulation of membrane potential  identical protein binding  cellular response to cAMP  cellular response to cGMP  potassium ion transmembrane transport  potassium ion transmembrane transport  
NDEx NetworkHCN2
Atlas of Cancer Signalling NetworkHCN2
Wikipedia pathwaysHCN2
Orthology - Evolution
OrthoDB610
GeneTree (enSembl)ENSG00000099822
Phylogenetic Trees/Animal Genes : TreeFamHCN2
HOVERGENQ9UL51
HOGENOMQ9UL51
Homologs : HomoloGeneHCN2
Homology/Alignments : Family Browser (UCSC)HCN2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHCN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HCN2
dbVarHCN2
ClinVarHCN2
1000_GenomesHCN2 
Exome Variant ServerHCN2
ExAC (Exome Aggregation Consortium)HCN2 (select the gene name)
Genetic variants : HAPMAP610
Genomic Variants (DGV)HCN2 [DGVbeta]
DECIPHER (Syndromes)19:589893-617159  ENSG00000099822
CONAN: Copy Number AnalysisHCN2 
Mutations
ICGC Data PortalHCN2 
TCGA Data PortalHCN2 
Broad Tumor PortalHCN2
OASIS PortalHCN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHCN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHCN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HCN2
DgiDB (Drug Gene Interaction Database)HCN2
DoCM (Curated mutations)HCN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HCN2 (select a term)
intoGenHCN2
Cancer3DHCN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602781   
Orphanet
MedgenHCN2
Genetic Testing Registry HCN2
NextProtQ9UL51 [Medical]
TSGene610
GENETestsHCN2
Huge Navigator HCN2 [HugePedia]
snp3D : Map Gene to Disease610
BioCentury BCIQHCN2
ClinGenHCN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD610
Chemical/Pharm GKB GenePA78
Clinical trialHCN2
Miscellaneous
canSAR (ICR)HCN2 (select the gene name)
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHCN2
EVEXHCN2
GoPubMedHCN2
iHOPHCN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Mar 14 12:07:32 CET 2017

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