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HCN3 (hyperpolarization activated cyclic nucleotide gated potassium channel 3)

Identity

Alias (NCBI)-
HGNC (Hugo) HCN3
HGNC Alias symbKIAA1535
HGNC Previous namehyperpolarization activated cyclic nucleotide-gated potassium channel 3
LocusID (NCBI) 57657
Atlas_Id 64210
Location 1q22  [Link to chromosome band 1q22]
Location_base_pair Starts at 155277463 and ends at 155289848 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HCN3 (1q22) / MUC1 (1q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)HCN3   19183
Cards
Entrez_Gene (NCBI)HCN3    hyperpolarization activated cyclic nucleotide gated potassium channel 3
Aliases
GeneCards (Weizmann)HCN3
Ensembl hg19 (Hinxton)ENSG00000143630 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143630 [Gene_View]  ENSG00000143630 [Sequence]  chr1:155277463-155289848 [Contig_View]  HCN3 [Vega]
ICGC DataPortalENSG00000143630
TCGA cBioPortalHCN3
AceView (NCBI)HCN3
Genatlas (Paris)HCN3
SOURCE (Princeton)HCN3
Genetics Home Reference (NIH)HCN3
Genomic and cartography
GoldenPath hg38 (UCSC)HCN3  -     chr1:155277463-155289848 +  1q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HCN3  -     1q22   [Description]    (hg19-Feb_2009)
GoldenPathHCN3 - 1q22 [CytoView hg19]  HCN3 - 1q22 [CytoView hg38]
ImmunoBaseENSG00000143630
Genome Data Viewer NCBIHCN3 [Mapview hg19]  
OMIM609973   
Gene and transcription
Genbank (Entrez)AB040968 AF488550 AK055840 AK299333 BC000066
RefSeq transcript (Entrez)NM_020897
Consensus coding sequences : CCDS (NCBI)HCN3
Gene ExpressionHCN3 [ NCBI-GEO ]   HCN3 [ EBI - ARRAY_EXPRESS ]   HCN3 [ SEEK ]   HCN3 [ MEM ]
Gene Expression Viewer (FireBrowse)HCN3 [ Firebrowse - Broad ]
GenevisibleExpression of HCN3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57657
GTEX Portal (Tissue expression)HCN3
Human Protein AtlasENSG00000143630-HCN3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P1Z3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P1Z3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P1Z3
PhosPhoSitePlusQ9P1Z3
Domaine pattern : Prosite (Expaxy)CNMP_BINDING_3 (PS50042)   
Domains : Interpro (EBI)cNMP-bd-like    cNMP-bd_dom    Ion_trans_dom    Ion_trans_N    K_chnl_volt-dep_EAG/ELK/ERG    RmlC-like_jellyroll   
Domain families : Pfam (Sanger)cNMP_binding (PF00027)    Ion_trans (PF00520)    Ion_trans_N (PF08412)   
Domain families : Pfam (NCBI)pfam00027    pfam00520    pfam08412   
Domain families : Smart (EMBL)cNMP (SM00100)  
Conserved Domain (NCBI)HCN3
SuperfamilyQ9P1Z3
AlphaFold pdb e-kbQ9P1Z3   
Human Protein Atlas [tissue]ENSG00000143630-HCN3 [tissue]
HPRD17093
Protein Interaction databases
DIP (DOE-UCLA)Q9P1Z3
IntAct (EBI)Q9P1Z3
BioGRIDHCN3
STRING (EMBL)HCN3
ZODIACHCN3
Ontologies - Pathways
QuickGOQ9P1Z3
Ontology : AmiGOvoltage-gated sodium channel activity  voltage-gated potassium channel activity  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  dendrite  cAMP binding  regulation of ion transmembrane transport  sodium ion transmembrane transport  regulation of membrane potential  neuronal cell body  cone cell pedicle  cellular response to cAMP  potassium ion transmembrane transport  potassium ion transmembrane transport  response to cisplatin  cellular response to dopamine  
Ontology : EGO-EBIvoltage-gated sodium channel activity  voltage-gated potassium channel activity  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  dendrite  cAMP binding  regulation of ion transmembrane transport  sodium ion transmembrane transport  regulation of membrane potential  neuronal cell body  cone cell pedicle  cellular response to cAMP  potassium ion transmembrane transport  potassium ion transmembrane transport  response to cisplatin  cellular response to dopamine  
NDEx NetworkHCN3
Atlas of Cancer Signalling NetworkHCN3
Wikipedia pathwaysHCN3
Orthology - Evolution
OrthoDB57657
GeneTree (enSembl)ENSG00000143630
Phylogenetic Trees/Animal Genes : TreeFamHCN3
Homologs : HomoloGeneHCN3
Homology/Alignments : Family Browser (UCSC)HCN3
Gene fusions - Rearrangements
Fusion : QuiverHCN3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHCN3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HCN3
dbVarHCN3
ClinVarHCN3
MonarchHCN3
1000_GenomesHCN3 
Exome Variant ServerHCN3
GNOMAD BrowserENSG00000143630
Varsome BrowserHCN3
ACMGHCN3 variants
VarityQ9P1Z3
Genomic Variants (DGV)HCN3 [DGVbeta]
DECIPHERHCN3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHCN3 
Mutations
ICGC Data PortalHCN3 
TCGA Data PortalHCN3 
Broad Tumor PortalHCN3
OASIS PortalHCN3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHCN3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHCN3
Mutations and Diseases : HGMDHCN3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHCN3
DgiDB (Drug Gene Interaction Database)HCN3
DoCM (Curated mutations)HCN3
CIViC (Clinical Interpretations of Variants in Cancer)HCN3
Cancer3DHCN3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609973   
Orphanet
DisGeNETHCN3
MedgenHCN3
Genetic Testing Registry HCN3
NextProtQ9P1Z3 [Medical]
GENETestsHCN3
Target ValidationHCN3
Huge Navigator HCN3 [HugePedia]
ClinGenHCN3
Clinical trials, drugs, therapy
MyCancerGenomeHCN3
Protein Interactions : CTDHCN3
Pharm GKB GenePA38821
PharosQ9P1Z3
Clinical trialHCN3
Miscellaneous
canSAR (ICR)HCN3
HarmonizomeHCN3
DataMed IndexHCN3
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHCN3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:52:46 CEST 2021

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