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HCN3 (hyperpolarization activated cyclic nucleotide gated potassium channel 3)

Identity

Alias_nameshyperpolarization activated cyclic nucleotide-gated potassium channel 3
Alias_symbol (synonym)KIAA1535
Other alias-
HGNC (Hugo) HCN3
LocusID (NCBI) 57657
Atlas_Id 64210
Location 1q22  [Link to chromosome band 1q22]
Location_base_pair Starts at 155277427 and ends at 155289848 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HCN3 (1q22) / MUC1 (1q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HCN3   19183
Cards
Entrez_Gene (NCBI)HCN3  57657  hyperpolarization activated cyclic nucleotide gated potassium channel 3
Aliases
GeneCards (Weizmann)HCN3
Ensembl hg19 (Hinxton)ENSG00000143630 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143630 [Gene_View]  chr1:155277427-155289848 [Contig_View]  HCN3 [Vega]
ICGC DataPortalENSG00000143630
TCGA cBioPortalHCN3
AceView (NCBI)HCN3
Genatlas (Paris)HCN3
WikiGenes57657
SOURCE (Princeton)HCN3
Genetics Home Reference (NIH)HCN3
Genomic and cartography
GoldenPath hg38 (UCSC)HCN3  -     chr1:155277427-155289848 +  1q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HCN3  -     1q22   [Description]    (hg19-Feb_2009)
EnsemblHCN3 - 1q22 [CytoView hg19]  HCN3 - 1q22 [CytoView hg38]
Mapping of homologs : NCBIHCN3 [Mapview hg19]  HCN3 [Mapview hg38]
OMIM609973   
Gene and transcription
Genbank (Entrez)AB040968 AF488550 AK055840 AK299333 BC000066
RefSeq transcript (Entrez)NM_020897
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HCN3
Cluster EST : UnigeneHs.706960 [ NCBI ]
CGAP (NCI)Hs.706960
Alternative Splicing GalleryENSG00000143630
Gene ExpressionHCN3 [ NCBI-GEO ]   HCN3 [ EBI - ARRAY_EXPRESS ]   HCN3 [ SEEK ]   HCN3 [ MEM ]
Gene Expression Viewer (FireBrowse)HCN3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57657
GTEX Portal (Tissue expression)HCN3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P1Z3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P1Z3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P1Z3
Splice isoforms : SwissVarQ9P1Z3
PhosPhoSitePlusQ9P1Z3
Domaine pattern : Prosite (Expaxy)CNMP_BINDING_3 (PS50042)   
Domains : Interpro (EBI)cNMP-bd-like    cNMP-bd_dom    Ion_trans_dom    Ion_trans_N    K_chnl_volt-dep_EAG/ELK/ERG    RmlC-like_jellyroll   
Domain families : Pfam (Sanger)cNMP_binding (PF00027)    Ion_trans (PF00520)    Ion_trans_N (PF08412)   
Domain families : Pfam (NCBI)pfam00027    pfam00520    pfam08412   
Domain families : Smart (EMBL)cNMP (SM00100)  
Conserved Domain (NCBI)HCN3
DMDM Disease mutations57657
Blocks (Seattle)HCN3
SuperfamilyQ9P1Z3
Human Protein AtlasENSG00000143630
Peptide AtlasQ9P1Z3
HPRD17093
IPIIPI00163724   IPI00719459   
Protein Interaction databases
DIP (DOE-UCLA)Q9P1Z3
IntAct (EBI)Q9P1Z3
FunCoupENSG00000143630
BioGRIDHCN3
STRING (EMBL)HCN3
ZODIACHCN3
Ontologies - Pathways
QuickGOQ9P1Z3
Ontology : AmiGOvoltage-gated sodium channel activity  voltage-gated potassium channel activity  plasma membrane  plasma membrane  integral component of plasma membrane  axon  dendrite  cAMP binding  regulation of ion transmembrane transport  sodium ion transmembrane transport  regulation of membrane potential  neuronal cell body  cone cell pedicle  regulation of postsynaptic membrane potential  cellular response to cAMP  potassium ion transmembrane transport  response to cisplatin  cellular response to dopamine  
Ontology : EGO-EBIvoltage-gated sodium channel activity  voltage-gated potassium channel activity  plasma membrane  plasma membrane  integral component of plasma membrane  axon  dendrite  cAMP binding  regulation of ion transmembrane transport  sodium ion transmembrane transport  regulation of membrane potential  neuronal cell body  cone cell pedicle  regulation of postsynaptic membrane potential  cellular response to cAMP  potassium ion transmembrane transport  response to cisplatin  cellular response to dopamine  
NDEx NetworkHCN3
Atlas of Cancer Signalling NetworkHCN3
Wikipedia pathwaysHCN3
Orthology - Evolution
OrthoDB57657
GeneTree (enSembl)ENSG00000143630
Phylogenetic Trees/Animal Genes : TreeFamHCN3
HOVERGENQ9P1Z3
HOGENOMQ9P1Z3
Homologs : HomoloGeneHCN3
Homology/Alignments : Family Browser (UCSC)HCN3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHCN3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HCN3
dbVarHCN3
ClinVarHCN3
1000_GenomesHCN3 
Exome Variant ServerHCN3
ExAC (Exome Aggregation Consortium)HCN3 (select the gene name)
Genetic variants : HAPMAP57657
Genomic Variants (DGV)HCN3 [DGVbeta]
DECIPHERHCN3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHCN3 
Mutations
ICGC Data PortalHCN3 
TCGA Data PortalHCN3 
Broad Tumor PortalHCN3
OASIS PortalHCN3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHCN3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHCN3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HCN3
DgiDB (Drug Gene Interaction Database)HCN3
DoCM (Curated mutations)HCN3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HCN3 (select a term)
intoGenHCN3
Cancer3DHCN3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609973   
Orphanet
MedgenHCN3
Genetic Testing Registry HCN3
NextProtQ9P1Z3 [Medical]
TSGene57657
GENETestsHCN3
Target ValidationHCN3
Huge Navigator HCN3 [HugePedia]
snp3D : Map Gene to Disease57657
BioCentury BCIQHCN3
ClinGenHCN3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57657
Chemical/Pharm GKB GenePA38821
Clinical trialHCN3
Miscellaneous
canSAR (ICR)HCN3 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHCN3
EVEXHCN3
GoPubMedHCN3
iHOPHCN3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 15:52:07 CEST 2017

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