HCN3 (hyperpolarization activated cyclic nucleotide gated potassium channel 3)

2014-11-01  

Identity

HGNC
LOCATION
1q22
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 57657
MIM: 609973
HGNC: 19183
Ensembl: ENSG00000143630

Variants:

dbSNP: 57657
ClinVar: 57657
TCGA: ENSG00000143630
COSMIC: HCN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143630ENST00000368358Q9P1Z3

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Potassium ChannelsREACTOMER-HSA-1296071
HCN channelsREACTOMER-HSA-1296061

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
160434892005Functional expression of the human HCN3 channel.43
216155892011Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases.12
233823862013Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3).8
259877892015Decreased expression of hyperpolarisation-activated cyclic nucleotide-gated channel 3 in Hirschsprung's disease.4

Citation

Dessen P

HCN3 (hyperpolarization activated cyclic nucleotide gated potassium channel 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64210/hcn3