Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4)

Identity

Alias (NCBI)SSS2
HGNC (Hugo) HCN4
HGNC Previous namehyperpolarization activated cyclic nucleotide-gated potassium channel 4
LocusID (NCBI) 10021
Atlas_Id 64211
Location 15q24.1  [Link to chromosome band 15q24]
Location_base_pair Starts at 73319859 and ends at 73368958 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)HCN4   16882
Cards
Entrez_Gene (NCBI)HCN4    hyperpolarization activated cyclic nucleotide gated potassium channel 4
AliasesSSS2
GeneCards (Weizmann)HCN4
Ensembl hg19 (Hinxton)ENSG00000138622 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138622 [Gene_View]  ENSG00000138622 [Sequence]  chr15:73319859-73368958 [Contig_View]  HCN4 [Vega]
ICGC DataPortalENSG00000138622
TCGA cBioPortalHCN4
AceView (NCBI)HCN4
Genatlas (Paris)HCN4
SOURCE (Princeton)HCN4
Genetics Home Reference (NIH)HCN4
Genomic and cartography
GoldenPath hg38 (UCSC)HCN4  -     chr15:73319859-73368958 -  15q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HCN4  -     15q24.1   [Description]    (hg19-Feb_2009)
GoldenPathHCN4 - 15q24.1 [CytoView hg19]  HCN4 - 15q24.1 [CytoView hg38]
ImmunoBaseENSG00000138622
Genome Data Viewer NCBIHCN4 [Mapview hg19]  
OMIM163800   605206   613123   
Gene and transcription
Genbank (Entrez)AJ132429 AJ238850 BM979827 BP291686 DQ854814
RefSeq transcript (Entrez)NM_005477
Consensus coding sequences : CCDS (NCBI)HCN4
Gene ExpressionHCN4 [ NCBI-GEO ]   HCN4 [ EBI - ARRAY_EXPRESS ]   HCN4 [ SEEK ]   HCN4 [ MEM ]
Gene Expression Viewer (FireBrowse)HCN4 [ Firebrowse - Broad ]
GenevisibleExpression of HCN4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10021
GTEX Portal (Tissue expression)HCN4
Human Protein AtlasENSG00000138622-HCN4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y3Q4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y3Q4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y3Q4
PhosPhoSitePlusQ9Y3Q4
Domaine pattern : Prosite (Expaxy)CNMP_BINDING_1 (PS00888)    CNMP_BINDING_3 (PS50042)   
Domains : Interpro (EBI)cNMP-bd-like    cNMP-bd_CS    cNMP-bd_dom    Ion_trans_dom    Ion_trans_N    K_chnl_volt-dep_EAG/ELK/ERG    RmlC-like_jellyroll    Volt_channel_dom_sf   
Domain families : Pfam (Sanger)cNMP_binding (PF00027)    Ion_trans (PF00520)    Ion_trans_N (PF08412)   
Domain families : Pfam (NCBI)pfam00027    pfam00520    pfam08412   
Domain families : Smart (EMBL)cNMP (SM00100)  
Conserved Domain (NCBI)HCN4
PDB (RSDB)2MNG    3OTF    3U11    4HBN    4KL1    4NVP    6GYN    6GYO   
PDB Europe2MNG    3OTF    3U11    4HBN    4KL1    4NVP    6GYN    6GYO   
PDB (PDBSum)2MNG    3OTF    3U11    4HBN    4KL1    4NVP    6GYN    6GYO   
PDB (IMB)2MNG    3OTF    3U11    4HBN    4KL1    4NVP    6GYN    6GYO   
Structural Biology KnowledgeBase2MNG    3OTF    3U11    4HBN    4KL1    4NVP    6GYN    6GYO   
SCOP (Structural Classification of Proteins)2MNG    3OTF    3U11    4HBN    4KL1    4NVP    6GYN    6GYO   
CATH (Classification of proteins structures)2MNG    3OTF    3U11    4HBN    4KL1    4NVP    6GYN    6GYO   
SuperfamilyQ9Y3Q4
AlphaFold pdb e-kbQ9Y3Q4   
Human Protein Atlas [tissue]ENSG00000138622-HCN4 [tissue]
HPRD09240
Protein Interaction databases
DIP (DOE-UCLA)Q9Y3Q4
IntAct (EBI)Q9Y3Q4
BioGRIDHCN4
STRING (EMBL)HCN4
ZODIACHCN4
Ontologies - Pathways
QuickGOQ9Y3Q4
Ontology : AmiGOregulation of heart rate  cardiac conduction system development  sinoatrial node development  regulation of membrane depolarization  intracellular cAMP-activated cation channel activity  voltage-gated sodium channel activity  voltage-gated potassium channel activity  voltage-gated potassium channel activity  plasma membrane  plasma membrane  cation transport  muscle contraction  blood circulation  cAMP binding  intrinsic component of plasma membrane  regulation of ion transmembrane transport  sodium ion transmembrane transport  regulation of membrane potential  identical protein binding  perinuclear region of cytoplasm  regulation of cardiac muscle contraction  cellular response to cAMP  cellular response to cGMP  potassium ion transmembrane transport  potassium ion transmembrane transport  potassium ion transmembrane transport  membrane depolarization during cardiac muscle cell action potential  SA node cell action potential  voltage-gated potassium channel activity involved in SA node cell action potential depolarization  membrane depolarization during SA node cell action potential  regulation of heart rate by cardiac conduction  sodium ion import across plasma membrane  HCN channel complex  regulation of cardiac muscle cell action potential involved in regulation of contraction  potassium ion import across plasma membrane  
Ontology : EGO-EBIregulation of heart rate  cardiac conduction system development  sinoatrial node development  regulation of membrane depolarization  intracellular cAMP-activated cation channel activity  voltage-gated sodium channel activity  voltage-gated potassium channel activity  voltage-gated potassium channel activity  plasma membrane  plasma membrane  cation transport  muscle contraction  blood circulation  cAMP binding  intrinsic component of plasma membrane  regulation of ion transmembrane transport  sodium ion transmembrane transport  regulation of membrane potential  identical protein binding  perinuclear region of cytoplasm  regulation of cardiac muscle contraction  cellular response to cAMP  cellular response to cGMP  potassium ion transmembrane transport  potassium ion transmembrane transport  potassium ion transmembrane transport  membrane depolarization during cardiac muscle cell action potential  SA node cell action potential  voltage-gated potassium channel activity involved in SA node cell action potential depolarization  membrane depolarization during SA node cell action potential  regulation of heart rate by cardiac conduction  sodium ion import across plasma membrane  HCN channel complex  regulation of cardiac muscle cell action potential involved in regulation of contraction  potassium ion import across plasma membrane  
NDEx NetworkHCN4
Atlas of Cancer Signalling NetworkHCN4
Wikipedia pathwaysHCN4
Orthology - Evolution
OrthoDB10021
GeneTree (enSembl)ENSG00000138622
Phylogenetic Trees/Animal Genes : TreeFamHCN4
Homologs : HomoloGeneHCN4
Homology/Alignments : Family Browser (UCSC)HCN4
Gene fusions - Rearrangements
Fusion : QuiverHCN4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHCN4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HCN4
dbVarHCN4
ClinVarHCN4
MonarchHCN4
1000_GenomesHCN4 
Exome Variant ServerHCN4
GNOMAD BrowserENSG00000138622
Varsome BrowserHCN4
ACMGHCN4 variants
VarityQ9Y3Q4
Genomic Variants (DGV)HCN4 [DGVbeta]
DECIPHERHCN4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHCN4 
Mutations
ICGC Data PortalHCN4 
TCGA Data PortalHCN4 
Broad Tumor PortalHCN4
OASIS PortalHCN4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHCN4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHCN4
Mutations and Diseases : HGMDHCN4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHCN4
DgiDB (Drug Gene Interaction Database)HCN4
DoCM (Curated mutations)HCN4
CIViC (Clinical Interpretations of Variants in Cancer)HCN4
Cancer3DHCN4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM163800    605206    613123   
Orphanet17628    8022   
DisGeNETHCN4
MedgenHCN4
Genetic Testing Registry HCN4
NextProtQ9Y3Q4 [Medical]
GENETestsHCN4
Target ValidationHCN4
Huge Navigator HCN4 [HugePedia]
ClinGenHCN4
Clinical trials, drugs, therapy
MyCancerGenomeHCN4
Protein Interactions : CTDHCN4
Pharm GKB GenePA394
PharosQ9Y3Q4
Clinical trialHCN4
Miscellaneous
canSAR (ICR)HCN4
HarmonizomeHCN4
DataMed IndexHCN4
Probes
Litterature
PubMed84 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHCN4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:52:46 CEST 2021

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