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HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4)

Identity

Alias_nameshyperpolarization activated cyclic nucleotide-gated potassium channel 4
Other aliasSSS2
HGNC (Hugo) HCN4
LocusID (NCBI) 10021
Atlas_Id 64211
Location 15q24.1  [Link to chromosome band 15q24]
Location_base_pair Starts at 73612200 and ends at 73661605 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HCN4   16882
Cards
Entrez_Gene (NCBI)HCN4  10021  hyperpolarization activated cyclic nucleotide gated potassium channel 4
AliasesSSS2
GeneCards (Weizmann)HCN4
Ensembl hg19 (Hinxton)ENSG00000138622 [Gene_View]  chr15:73612200-73661605 [Contig_View]  HCN4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000138622 [Gene_View]  chr15:73612200-73661605 [Contig_View]  HCN4 [Vega]
ICGC DataPortalENSG00000138622
TCGA cBioPortalHCN4
AceView (NCBI)HCN4
Genatlas (Paris)HCN4
WikiGenes10021
SOURCE (Princeton)HCN4
Genetics Home Reference (NIH)HCN4
Genomic and cartography
GoldenPath hg19 (UCSC)HCN4  -     chr15:73612200-73661605 -  15q24.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HCN4  -     15q24.1   [Description]    (hg38-Dec_2013)
EnsemblHCN4 - 15q24.1 [CytoView hg19]  HCN4 - 15q24.1 [CytoView hg38]
Mapping of homologs : NCBIHCN4 [Mapview hg19]  HCN4 [Mapview hg38]
OMIM163800   605206   613123   
Gene and transcription
Genbank (Entrez)AJ132429 AJ238850 BC156298 BC172471 BM979827
RefSeq transcript (Entrez)NM_005477
RefSeq genomic (Entrez)NC_000015 NC_018926 NG_009063 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)HCN4
Cluster EST : UnigeneHs.86941 [ NCBI ]
CGAP (NCI)Hs.86941
Alternative Splicing GalleryENSG00000138622
Gene ExpressionHCN4 [ NCBI-GEO ]   HCN4 [ EBI - ARRAY_EXPRESS ]   HCN4 [ SEEK ]   HCN4 [ MEM ]
Gene Expression Viewer (FireBrowse)HCN4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10021
GTEX Portal (Tissue expression)HCN4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y3Q4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y3Q4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y3Q4
Splice isoforms : SwissVarQ9Y3Q4
PhosPhoSitePlusQ9Y3Q4
Domaine pattern : Prosite (Expaxy)CNMP_BINDING_1 (PS00888)    CNMP_BINDING_3 (PS50042)   
Domains : Interpro (EBI)cNMP-bd-like    cNMP-bd_CS    cNMP-bd_dom    HCN4    Ion_trans_dom    Ion_trans_N    K_chnl_volt-dep_EAG/ELK/ERG    RmlC-like_jellyroll   
Domain families : Pfam (Sanger)cNMP_binding (PF00027)    Ion_trans (PF00520)    Ion_trans_N (PF08412)   
Domain families : Pfam (NCBI)pfam00027    pfam00520    pfam08412   
Domain families : Smart (EMBL)cNMP (SM00100)  
Conserved Domain (NCBI)HCN4
DMDM Disease mutations10021
Blocks (Seattle)HCN4
PDB (SRS)2MNG    3OTF    3U11    4HBN    4KL1    4NVP   
PDB (PDBSum)2MNG    3OTF    3U11    4HBN    4KL1    4NVP   
PDB (IMB)2MNG    3OTF    3U11    4HBN    4KL1    4NVP   
PDB (RSDB)2MNG    3OTF    3U11    4HBN    4KL1    4NVP   
Structural Biology KnowledgeBase2MNG    3OTF    3U11    4HBN    4KL1    4NVP   
SCOP (Structural Classification of Proteins)2MNG    3OTF    3U11    4HBN    4KL1    4NVP   
CATH (Classification of proteins structures)2MNG    3OTF    3U11    4HBN    4KL1    4NVP   
SuperfamilyQ9Y3Q4
Human Protein AtlasENSG00000138622
Peptide AtlasQ9Y3Q4
HPRD09240
IPIIPI00023164   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y3Q4
IntAct (EBI)Q9Y3Q4
FunCoupENSG00000138622
BioGRIDHCN4
STRING (EMBL)HCN4
ZODIACHCN4
Ontologies - Pathways
QuickGOQ9Y3Q4
Ontology : AmiGOin utero embryonic development  regulation of heart rate  regulation of membrane depolarization  intracellular cAMP activated cation channel activity  voltage-gated sodium channel activity  voltage-gated potassium channel activity  voltage-gated potassium channel activity  plasma membrane  plasma membrane  integral component of plasma membrane  cation transport  muscle contraction  synaptic transmission  blood circulation  cAMP binding  intrinsic component of plasma membrane  regulation of ion transmembrane transport  sodium ion transmembrane transport  regulation of membrane potential  identical protein binding  terminal bouton  perinuclear region of cytoplasm  regulation of cardiac muscle contraction  cellular response to cAMP  cellular response to cGMP  potassium ion transmembrane transport  potassium ion transmembrane transport  SA node cell action potential  regulation of heart rate by cardiac conduction  
Ontology : EGO-EBIin utero embryonic development  regulation of heart rate  regulation of membrane depolarization  intracellular cAMP activated cation channel activity  voltage-gated sodium channel activity  voltage-gated potassium channel activity  voltage-gated potassium channel activity  plasma membrane  plasma membrane  integral component of plasma membrane  cation transport  muscle contraction  synaptic transmission  blood circulation  cAMP binding  intrinsic component of plasma membrane  regulation of ion transmembrane transport  sodium ion transmembrane transport  regulation of membrane potential  identical protein binding  terminal bouton  perinuclear region of cytoplasm  regulation of cardiac muscle contraction  cellular response to cAMP  cellular response to cGMP  potassium ion transmembrane transport  potassium ion transmembrane transport  SA node cell action potential  regulation of heart rate by cardiac conduction  
NDEx NetworkHCN4
Atlas of Cancer Signalling NetworkHCN4
Wikipedia pathwaysHCN4
Orthology - Evolution
OrthoDB10021
GeneTree (enSembl)ENSG00000138622
Phylogenetic Trees/Animal Genes : TreeFamHCN4
HOVERGENQ9Y3Q4
HOGENOMQ9Y3Q4
Homologs : HomoloGeneHCN4
Homology/Alignments : Family Browser (UCSC)HCN4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHCN4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HCN4
dbVarHCN4
ClinVarHCN4
1000_GenomesHCN4 
Exome Variant ServerHCN4
ExAC (Exome Aggregation Consortium)HCN4 (select the gene name)
Genetic variants : HAPMAP10021
Genomic Variants (DGV)HCN4 [DGVbeta]
DECIPHER (Syndromes)15:73612200-73661605  ENSG00000138622
CONAN: Copy Number AnalysisHCN4 
Mutations
ICGC Data PortalHCN4 
TCGA Data PortalHCN4 
Broad Tumor PortalHCN4
OASIS PortalHCN4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHCN4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHCN4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HCN4
DgiDB (Drug Gene Interaction Database)HCN4
DoCM (Curated mutations)HCN4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HCN4 (select a term)
intoGenHCN4
Cancer3DHCN4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM163800    605206    613123   
Orphanet17628    8022   
MedgenHCN4
Genetic Testing Registry HCN4
NextProtQ9Y3Q4 [Medical]
TSGene10021
GENETestsHCN4
Huge Navigator HCN4 [HugePedia]
snp3D : Map Gene to Disease10021
BioCentury BCIQHCN4
ClinGenHCN4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10021
Chemical/Pharm GKB GenePA394
Clinical trialHCN4
Miscellaneous
canSAR (ICR)HCN4 (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHCN4
EVEXHCN4
GoPubMedHCN4
iHOPHCN4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 12:07:33 CET 2017

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