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HCRT (hypocretin neuropeptide precursor)

Identity

Alias_nameshypocretin (orexin) neuropeptide precursor
Alias_symbol (synonym)PPOX
OX
Other aliasNRCLP1
HGNC (Hugo) HCRT
LocusID (NCBI) 3060
Atlas_Id 55398
Location 17q21.2  [Link to chromosome band 17q21]
Location_base_pair Starts at 42184060 and ends at 42185452 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HCRT   4847
Cards
Entrez_Gene (NCBI)HCRT  3060  hypocretin neuropeptide precursor
AliasesNRCLP1; OX; PPOX
GeneCards (Weizmann)HCRT
Ensembl hg19 (Hinxton)ENSG00000161610 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000161610 [Gene_View]  chr17:42184060-42185452 [Contig_View]  HCRT [Vega]
ICGC DataPortalENSG00000161610
TCGA cBioPortalHCRT
AceView (NCBI)HCRT
Genatlas (Paris)HCRT
WikiGenes3060
SOURCE (Princeton)HCRT
Genetics Home Reference (NIH)HCRT
Genomic and cartography
GoldenPath hg38 (UCSC)HCRT  -     chr17:42184060-42185452 -  17q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HCRT  -     17q21.2   [Description]    (hg19-Feb_2009)
EnsemblHCRT - 17q21.2 [CytoView hg19]  HCRT - 17q21.2 [CytoView hg38]
Mapping of homologs : NCBIHCRT [Mapview hg19]  HCRT [Mapview hg38]
OMIM161400   602358   
Gene and transcription
Genbank (Entrez)AF041240 BC111915
RefSeq transcript (Entrez)NM_001524
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HCRT
Cluster EST : UnigeneHs.158348 [ NCBI ]
CGAP (NCI)Hs.158348
Alternative Splicing GalleryENSG00000161610
Gene ExpressionHCRT [ NCBI-GEO ]   HCRT [ EBI - ARRAY_EXPRESS ]   HCRT [ SEEK ]   HCRT [ MEM ]
Gene Expression Viewer (FireBrowse)HCRT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3060
GTEX Portal (Tissue expression)HCRT
Human Protein AtlasENSG00000161610-HCRT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43612   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43612  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43612
Splice isoforms : SwissVarO43612
PhosPhoSitePlusO43612
Domains : Interpro (EBI)Orexin   
Domain families : Pfam (Sanger)Orexin (PF02072)   
Domain families : Pfam (NCBI)pfam02072   
Conserved Domain (NCBI)HCRT
DMDM Disease mutations3060
Blocks (Seattle)HCRT
PDB (SRS)1CQ0    1R02    1UVQ    1WSO   
PDB (PDBSum)1CQ0    1R02    1UVQ    1WSO   
PDB (IMB)1CQ0    1R02    1UVQ    1WSO   
PDB (RSDB)1CQ0    1R02    1UVQ    1WSO   
Structural Biology KnowledgeBase1CQ0    1R02    1UVQ    1WSO   
SCOP (Structural Classification of Proteins)1CQ0    1R02    1UVQ    1WSO   
CATH (Classification of proteins structures)1CQ0    1R02    1UVQ    1WSO   
SuperfamilyO43612
Human Protein Atlas [tissue]ENSG00000161610-HCRT [tissue]
Peptide AtlasO43612
HPRD03836
IPIIPI00013373   
Protein Interaction databases
DIP (DOE-UCLA)O43612
IntAct (EBI)O43612
FunCoupENSG00000161610
BioGRIDHCRT
STRING (EMBL)HCRT
ZODIACHCRT
Ontologies - Pathways
QuickGOO43612
Ontology : AmiGOtemperature homeostasis  neuropeptide hormone activity  extracellular region  rough endoplasmic reticulum  phospholipase C-activating G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  protein kinase C-activating G-protein coupled receptor signaling pathway  neuropeptide signaling pathway  chemical synaptic transmission  synaptic vesicle  negative regulation of DNA replication  cell junction  secretory granule  type 1 hypocretin receptor binding  type 2 hypocretin receptor binding  eating behavior  negative regulation of potassium ion transport  regulation of neurotransmitter secretion  perinuclear region of cytoplasm  positive regulation of calcium ion transport  negative regulation of transmission of nerve impulse  positive regulation of transmission of nerve impulse  excitatory postsynaptic potential  postsynapse  
Ontology : EGO-EBItemperature homeostasis  neuropeptide hormone activity  extracellular region  rough endoplasmic reticulum  phospholipase C-activating G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  protein kinase C-activating G-protein coupled receptor signaling pathway  neuropeptide signaling pathway  chemical synaptic transmission  synaptic vesicle  negative regulation of DNA replication  cell junction  secretory granule  type 1 hypocretin receptor binding  type 2 hypocretin receptor binding  eating behavior  negative regulation of potassium ion transport  regulation of neurotransmitter secretion  perinuclear region of cytoplasm  positive regulation of calcium ion transport  negative regulation of transmission of nerve impulse  positive regulation of transmission of nerve impulse  excitatory postsynaptic potential  postsynapse  
NDEx NetworkHCRT
Atlas of Cancer Signalling NetworkHCRT
Wikipedia pathwaysHCRT
Orthology - Evolution
OrthoDB3060
GeneTree (enSembl)ENSG00000161610
Phylogenetic Trees/Animal Genes : TreeFamHCRT
HOVERGENO43612
HOGENOMO43612
Homologs : HomoloGeneHCRT
Homology/Alignments : Family Browser (UCSC)HCRT
Gene fusions - Rearrangements
Tumor Fusion PortalHCRT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHCRT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HCRT
dbVarHCRT
ClinVarHCRT
1000_GenomesHCRT 
Exome Variant ServerHCRT
ExAC (Exome Aggregation Consortium)ENSG00000161610
GNOMAD BrowserENSG00000161610
Genetic variants : HAPMAP3060
Genomic Variants (DGV)HCRT [DGVbeta]
DECIPHERHCRT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHCRT 
Mutations
ICGC Data PortalHCRT 
TCGA Data PortalHCRT 
Broad Tumor PortalHCRT
OASIS PortalHCRT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHCRT  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHCRT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HCRT
DgiDB (Drug Gene Interaction Database)HCRT
DoCM (Curated mutations)HCRT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HCRT (select a term)
intoGenHCRT
Cancer3DHCRT(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM161400    602358   
Orphanet3637    11576   
DisGeNETHCRT
MedgenHCRT
Genetic Testing Registry HCRT
NextProtO43612 [Medical]
TSGene3060
GENETestsHCRT
Target ValidationHCRT
Huge Navigator HCRT [HugePedia]
snp3D : Map Gene to Disease3060
BioCentury BCIQHCRT
ClinGenHCRT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3060
Chemical/Pharm GKB GenePA29221
Clinical trialHCRT
Miscellaneous
canSAR (ICR)HCRT (select the gene name)
Probes
Litterature
PubMed109 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHCRT
EVEXHCRT
GoPubMedHCRT
iHOPHCRT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:15:51 CET 2017

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