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HCRTR2 (hypocretin receptor 2)

Identity

Alias_nameshypocretin (orexin) receptor 2
Alias_symbol (synonym)OX2R
Other alias
HGNC (Hugo) HCRTR2
LocusID (NCBI) 3062
Atlas_Id 53420
Location 6p12.1  [Link to chromosome band 6p12]
Location_base_pair Starts at 55106460 and ends at 55282741 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HCRTR2   4849
Cards
Entrez_Gene (NCBI)HCRTR2  3062  hypocretin receptor 2
AliasesOX2R
GeneCards (Weizmann)HCRTR2
Ensembl hg19 (Hinxton)ENSG00000137252 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137252 [Gene_View]  ENSG00000137252 [Sequence]  chr6:55106460-55282741 [Contig_View]  HCRTR2 [Vega]
ICGC DataPortalENSG00000137252
TCGA cBioPortalHCRTR2
AceView (NCBI)HCRTR2
Genatlas (Paris)HCRTR2
WikiGenes3062
SOURCE (Princeton)HCRTR2
Genetics Home Reference (NIH)HCRTR2
Genomic and cartography
GoldenPath hg38 (UCSC)HCRTR2  -     chr6:55106460-55282741 +  6p12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HCRTR2  -     6p12.1   [Description]    (hg19-Feb_2009)
EnsemblHCRTR2 - 6p12.1 [CytoView hg19]  HCRTR2 - 6p12.1 [CytoView hg38]
Mapping of homologs : NCBIHCRTR2 [Mapview hg19]  HCRTR2 [Mapview hg38]
OMIM602393   
Gene and transcription
Genbank (Entrez)AF041245 AK307819 AK314279 BC035858 EF633107
RefSeq transcript (Entrez)NM_001526
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HCRTR2
Cluster EST : UnigeneHs.699147 [ NCBI ]
CGAP (NCI)Hs.699147
Alternative Splicing GalleryENSG00000137252
Gene ExpressionHCRTR2 [ NCBI-GEO ]   HCRTR2 [ EBI - ARRAY_EXPRESS ]   HCRTR2 [ SEEK ]   HCRTR2 [ MEM ]
Gene Expression Viewer (FireBrowse)HCRTR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3062
GTEX Portal (Tissue expression)HCRTR2
Human Protein AtlasENSG00000137252-HCRTR2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43614   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43614  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43614
Splice isoforms : SwissVarO43614
PhosPhoSitePlusO43614
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Orexin_rcpt    Orexin_rcpt_2   
Domain families : Pfam (Sanger)7tm_1 (PF00001)    Orexin_rec2 (PF03827)   
Domain families : Pfam (NCBI)pfam00001    pfam03827   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)HCRTR2
DMDM Disease mutations3062
Blocks (Seattle)HCRTR2
PDB (SRS)4S0V    5WQC    5WS3   
PDB (PDBSum)4S0V    5WQC    5WS3   
PDB (IMB)4S0V    5WQC    5WS3   
PDB (RSDB)4S0V    5WQC    5WS3   
Structural Biology KnowledgeBase4S0V    5WQC    5WS3   
SCOP (Structural Classification of Proteins)4S0V    5WQC    5WS3   
CATH (Classification of proteins structures)4S0V    5WQC    5WS3   
SuperfamilyO43614
Human Protein Atlas [tissue]ENSG00000137252-HCRTR2 [tissue]
Peptide AtlasO43614
HPRD08374
IPIIPI00013376   
Protein Interaction databases
DIP (DOE-UCLA)O43614
IntAct (EBI)O43614
FunCoupENSG00000137252
BioGRIDHCRTR2
STRING (EMBL)HCRTR2
ZODIACHCRTR2
Ontologies - Pathways
QuickGOO43614
Ontology : AmiGOG protein-coupled receptor activity  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  phospholipase C-activating G protein-coupled receptor signaling pathway  neuropeptide signaling pathway  chemical synaptic transmission  feeding behavior  neuropeptide receptor activity  regulation of circadian sleep/wake cycle, wakefulness  orexin receptor activity  orexin receptor activity  peptide hormone binding  circadian sleep/wake cycle process  regulation of cytosolic calcium ion concentration  
Ontology : EGO-EBIG protein-coupled receptor activity  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  phospholipase C-activating G protein-coupled receptor signaling pathway  neuropeptide signaling pathway  chemical synaptic transmission  feeding behavior  neuropeptide receptor activity  regulation of circadian sleep/wake cycle, wakefulness  orexin receptor activity  orexin receptor activity  peptide hormone binding  circadian sleep/wake cycle process  regulation of cytosolic calcium ion concentration  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkHCRTR2
Atlas of Cancer Signalling NetworkHCRTR2
Wikipedia pathwaysHCRTR2
Orthology - Evolution
OrthoDB3062
GeneTree (enSembl)ENSG00000137252
Phylogenetic Trees/Animal Genes : TreeFamHCRTR2
HOVERGENO43614
HOGENOMO43614
Homologs : HomoloGeneHCRTR2
Homology/Alignments : Family Browser (UCSC)HCRTR2
Gene fusions - Rearrangements
Fusion : QuiverHCRTR2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHCRTR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HCRTR2
dbVarHCRTR2
ClinVarHCRTR2
1000_GenomesHCRTR2 
Exome Variant ServerHCRTR2
ExAC (Exome Aggregation Consortium)ENSG00000137252
GNOMAD BrowserENSG00000137252
Varsome BrowserHCRTR2
Genetic variants : HAPMAP3062
Genomic Variants (DGV)HCRTR2 [DGVbeta]
DECIPHERHCRTR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHCRTR2 
Mutations
ICGC Data PortalHCRTR2 
TCGA Data PortalHCRTR2 
Broad Tumor PortalHCRTR2
OASIS PortalHCRTR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHCRTR2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHCRTR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HCRTR2
DgiDB (Drug Gene Interaction Database)HCRTR2
DoCM (Curated mutations)HCRTR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HCRTR2 (select a term)
intoGenHCRTR2
Cancer3DHCRTR2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602393   
Orphanet
DisGeNETHCRTR2
MedgenHCRTR2
Genetic Testing Registry HCRTR2
NextProtO43614 [Medical]
TSGene3062
GENETestsHCRTR2
Target ValidationHCRTR2
Huge Navigator HCRTR2 [HugePedia]
snp3D : Map Gene to Disease3062
BioCentury BCIQHCRTR2
ClinGenHCRTR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3062
Chemical/Pharm GKB GenePA29223
Clinical trialHCRTR2
Miscellaneous
canSAR (ICR)HCRTR2 (select the gene name)
Probes
Litterature
PubMed69 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHCRTR2
EVEXHCRTR2
GoPubMedHCRTR2
iHOPHCRTR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:10:21 CET 2018

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