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HCST (hematopoietic cell signal transducer)

Identity

Alias (NCBI)DAP10
KAP10
PIK3AP
HGNC (Hugo) HCST
HGNC Alias symbDAP10
DKFZP586C1522
KAP10
HGNC Alias nameDNAX-activation protein 10
 kinase assoc pro of ~10kDa
HGNC Previous namePIK3AP
HGNC Previous namephosphoinositide-3-kinase adaptor protein
LocusID (NCBI) 10870
Atlas_Id 46745
Location 19q13.12  [Link to chromosome band 19q13]
Location_base_pair Starts at 35902529 and ends at 35904377 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DST (6p12.1) / HCST (19q13.12)HCST (19q13.12) / IMMT (2p11.2)HCST (19q13.12) / TTC23 (15q26.3)
WDR62 (19q13.12) / HCST (19q13.12)DST 6p12.1 / HCST 19q13.12WDR62 19q13.12 / HCST 19q13.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)HCST   16977
Cards
Entrez_Gene (NCBI)HCST    hematopoietic cell signal transducer
AliasesDAP10; KAP10; PIK3AP
GeneCards (Weizmann)HCST
Ensembl hg19 (Hinxton)ENSG00000126264 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126264 [Gene_View]  ENSG00000126264 [Sequence]  chr19:35902529-35904377 [Contig_View]  HCST [Vega]
ICGC DataPortalENSG00000126264
TCGA cBioPortalHCST
AceView (NCBI)HCST
Genatlas (Paris)HCST
SOURCE (Princeton)HCST
Genetics Home Reference (NIH)HCST
Genomic and cartography
GoldenPath hg38 (UCSC)HCST  -     chr19:35902529-35904377 +  19q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HCST  -     19q13.12   [Description]    (hg19-Feb_2009)
GoldenPathHCST - 19q13.12 [CytoView hg19]  HCST - 19q13.12 [CytoView hg38]
ImmunoBaseENSG00000126264
Genome Data Viewer NCBIHCST [Mapview hg19]  
OMIM604089   
Gene and transcription
Genbank (Entrez)AF072844 AF122904 AF172929 AF285447 AL050163
RefSeq transcript (Entrez)NM_001007469 NM_014266
Consensus coding sequences : CCDS (NCBI)HCST
Gene ExpressionHCST [ NCBI-GEO ]   HCST [ EBI - ARRAY_EXPRESS ]   HCST [ SEEK ]   HCST [ MEM ]
Gene Expression Viewer (FireBrowse)HCST [ Firebrowse - Broad ]
GenevisibleExpression of HCST in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10870
GTEX Portal (Tissue expression)HCST
Human Protein AtlasENSG00000126264-HCST [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBK5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBK5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBK5
PhosPhoSitePlusQ9UBK5
Domains : Interpro (EBI)HCST   
Domain families : Pfam (Sanger)DAP10 (PF07213)   
Domain families : Pfam (NCBI)pfam07213   
Conserved Domain (NCBI)HCST
SuperfamilyQ9UBK5
AlphaFold pdb e-kbQ9UBK5   
Human Protein Atlas [tissue]ENSG00000126264-HCST [tissue]
HPRD04971
Protein Interaction databases
DIP (DOE-UCLA)Q9UBK5
IntAct (EBI)Q9UBK5
BioGRIDHCST
STRING (EMBL)HCST
ZODIACHCST
Ontologies - Pathways
QuickGOQ9UBK5
Ontology : AmiGOsignaling receptor binding  signaling receptor binding  protein binding  plasma membrane  protein phosphorylation  cell surface  positive regulation of phosphatidylinositol 3-kinase signaling  positive regulation of phosphatidylinositol 3-kinase signaling  integral component of membrane  phosphatidylinositol 3-kinase binding  phosphatidylinositol 3-kinase binding  regulation of immune response  
Ontology : EGO-EBIsignaling receptor binding  signaling receptor binding  protein binding  plasma membrane  protein phosphorylation  cell surface  positive regulation of phosphatidylinositol 3-kinase signaling  positive regulation of phosphatidylinositol 3-kinase signaling  integral component of membrane  phosphatidylinositol 3-kinase binding  phosphatidylinositol 3-kinase binding  regulation of immune response  
Pathways : KEGGNatural killer cell mediated cytotoxicity   
NDEx NetworkHCST
Atlas of Cancer Signalling NetworkHCST
Wikipedia pathwaysHCST
Orthology - Evolution
OrthoDB10870
GeneTree (enSembl)ENSG00000126264
Phylogenetic Trees/Animal Genes : TreeFamHCST
Homologs : HomoloGeneHCST
Homology/Alignments : Family Browser (UCSC)HCST
Gene fusions - Rearrangements
Fusion : MitelmanDST/HCST [6p12.1/19q13.12]  
Fusion : MitelmanWDR62/HCST [19q13.12/19q13.12]  
Fusion : QuiverHCST
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHCST [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HCST
dbVarHCST
ClinVarHCST
MonarchHCST
1000_GenomesHCST 
Exome Variant ServerHCST
GNOMAD BrowserENSG00000126264
Varsome BrowserHCST
ACMGHCST variants
VarityQ9UBK5
Genomic Variants (DGV)HCST [DGVbeta]
DECIPHERHCST [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHCST 
Mutations
ICGC Data PortalHCST 
TCGA Data PortalHCST 
Broad Tumor PortalHCST
OASIS PortalHCST [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHCST  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHCST
Mutations and Diseases : HGMDHCST
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHCST
DgiDB (Drug Gene Interaction Database)HCST
DoCM (Curated mutations)HCST
CIViC (Clinical Interpretations of Variants in Cancer)HCST
Cancer3DHCST
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604089   
Orphanet
DisGeNETHCST
MedgenHCST
Genetic Testing Registry HCST
NextProtQ9UBK5 [Medical]
GENETestsHCST
Target ValidationHCST
Huge Navigator HCST [HugePedia]
ClinGenHCST
Clinical trials, drugs, therapy
MyCancerGenomeHCST
Protein Interactions : CTDHCST
Pharm GKB GenePA134956649
PharosQ9UBK5
Clinical trialHCST
Miscellaneous
canSAR (ICR)HCST
HarmonizomeHCST
DataMed IndexHCST
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHCST
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:12:09 CEST 2021

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