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HCST (hematopoietic cell signal transducer)

Identity

Alias_namesPIK3AP
phosphoinositide-3-kinase adaptor protein
Alias_symbol (synonym)DAP10
DKFZP586C1522
KAP10
Other alias
HGNC (Hugo) HCST
LocusID (NCBI) 10870
Atlas_Id 46745
Location 19q13.12  [Link to chromosome band 19q13]
Location_base_pair Starts at 35902480 and ends at 35904271 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DST (6p12.1) / HCST (19q13.12)HCST (19q13.12) / IMMT (2p11.2)HCST (19q13.12) / TTC23 (15q26.3)
WDR62 (19q13.12) / HCST (19q13.12)DST 6p12.1 / HCST 19q13.12WDR62 19q13.12 / HCST 19q13.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(6;19)(p12;q13) DST/HCST
WDR62/HCST (19q13)


External links

Nomenclature
HGNC (Hugo)HCST   16977
Cards
Entrez_Gene (NCBI)HCST  10870  hematopoietic cell signal transducer
AliasesDAP10; KAP10; PIK3AP
GeneCards (Weizmann)HCST
Ensembl hg19 (Hinxton)ENSG00000126264 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126264 [Gene_View]  ENSG00000126264 [Sequence]  chr19:35902480-35904271 [Contig_View]  HCST [Vega]
ICGC DataPortalENSG00000126264
TCGA cBioPortalHCST
AceView (NCBI)HCST
Genatlas (Paris)HCST
WikiGenes10870
SOURCE (Princeton)HCST
Genetics Home Reference (NIH)HCST
Genomic and cartography
GoldenPath hg38 (UCSC)HCST  -     chr19:35902480-35904271 +  19q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HCST  -     19q13.12   [Description]    (hg19-Feb_2009)
EnsemblHCST - 19q13.12 [CytoView hg19]  HCST - 19q13.12 [CytoView hg38]
Mapping of homologs : NCBIHCST [Mapview hg19]  HCST [Mapview hg38]
OMIM604089   
Gene and transcription
Genbank (Entrez)AF072844 AF122904 AF172929 AF285447 AL050163
RefSeq transcript (Entrez)NM_001007469 NM_014266
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HCST
Cluster EST : UnigeneHs.117339 [ NCBI ]
CGAP (NCI)Hs.117339
Alternative Splicing GalleryENSG00000126264
Gene ExpressionHCST [ NCBI-GEO ]   HCST [ EBI - ARRAY_EXPRESS ]   HCST [ SEEK ]   HCST [ MEM ]
Gene Expression Viewer (FireBrowse)HCST [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10870
GTEX Portal (Tissue expression)HCST
Human Protein AtlasENSG00000126264-HCST [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBK5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBK5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBK5
Splice isoforms : SwissVarQ9UBK5
PhosPhoSitePlusQ9UBK5
Domains : Interpro (EBI)HCST   
Domain families : Pfam (Sanger)DAP10 (PF07213)   
Domain families : Pfam (NCBI)pfam07213   
Conserved Domain (NCBI)HCST
DMDM Disease mutations10870
Blocks (Seattle)HCST
SuperfamilyQ9UBK5
Human Protein Atlas [tissue]ENSG00000126264-HCST [tissue]
Peptide AtlasQ9UBK5
HPRD04971
IPIIPI00464987   IPI00514454   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBK5
IntAct (EBI)Q9UBK5
FunCoupENSG00000126264
BioGRIDHCST
STRING (EMBL)HCST
ZODIACHCST
Ontologies - Pathways
QuickGOQ9UBK5
Ontology : AmiGOsignaling receptor binding  signaling receptor binding  protein binding  plasma membrane  protein phosphorylation  cell surface  positive regulation of phosphatidylinositol 3-kinase signaling  positive regulation of phosphatidylinositol 3-kinase signaling  integral component of membrane  phosphatidylinositol 3-kinase binding  phosphatidylinositol 3-kinase binding  regulation of immune response  
Ontology : EGO-EBIsignaling receptor binding  signaling receptor binding  protein binding  plasma membrane  protein phosphorylation  cell surface  positive regulation of phosphatidylinositol 3-kinase signaling  positive regulation of phosphatidylinositol 3-kinase signaling  integral component of membrane  phosphatidylinositol 3-kinase binding  phosphatidylinositol 3-kinase binding  regulation of immune response  
Pathways : KEGGNatural killer cell mediated cytotoxicity   
NDEx NetworkHCST
Atlas of Cancer Signalling NetworkHCST
Wikipedia pathwaysHCST
Orthology - Evolution
OrthoDB10870
GeneTree (enSembl)ENSG00000126264
Phylogenetic Trees/Animal Genes : TreeFamHCST
HOVERGENQ9UBK5
HOGENOMQ9UBK5
Homologs : HomoloGeneHCST
Homology/Alignments : Family Browser (UCSC)HCST
Gene fusions - Rearrangements
Fusion : MitelmanDST/HCST [6p12.1/19q13.12]  [t(6;19)(p12;q13)]  
Fusion : MitelmanWDR62/HCST [19q13.12/19q13.12]  [t(19;19)(q13;q13)]  
Fusion PortalDST 6p12.1 HCST 19q13.12 LUAD
Fusion PortalWDR62 19q13.12 HCST 19q13.12 BLCA
Fusion : QuiverHCST
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHCST [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HCST
dbVarHCST
ClinVarHCST
1000_GenomesHCST 
Exome Variant ServerHCST
ExAC (Exome Aggregation Consortium)ENSG00000126264
GNOMAD BrowserENSG00000126264
Varsome BrowserHCST
Genetic variants : HAPMAP10870
Genomic Variants (DGV)HCST [DGVbeta]
DECIPHERHCST [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHCST 
Mutations
ICGC Data PortalHCST 
TCGA Data PortalHCST 
Broad Tumor PortalHCST
OASIS PortalHCST [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHCST  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHCST
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HCST
DgiDB (Drug Gene Interaction Database)HCST
DoCM (Curated mutations)HCST (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HCST (select a term)
intoGenHCST
Cancer3DHCST(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604089   
Orphanet
DisGeNETHCST
MedgenHCST
Genetic Testing Registry HCST
NextProtQ9UBK5 [Medical]
TSGene10870
GENETestsHCST
Target ValidationHCST
Huge Navigator HCST [HugePedia]
snp3D : Map Gene to Disease10870
BioCentury BCIQHCST
ClinGenHCST
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10870
Chemical/Pharm GKB GenePA134956649
Clinical trialHCST
Miscellaneous
canSAR (ICR)HCST (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHCST
EVEXHCST
GoPubMedHCST
iHOPHCST
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:10:21 CET 2018

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