HDAC10 (histone deacetylase 10)

2007-02-01  

Identity

HGNC
LOCATION
22q13.33
LOCUSID
ALIAS
HD10
FUSION GENES

Other Information

Locus ID:

NCBI: 83933
MIM: 608544
HGNC: 18128
Ensembl: ENSG00000100429

Variants:

dbSNP: 83933
ClinVar: 83933
TCGA: ENSG00000100429
COSMIC: HDAC10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100429ENST00000216271Q969S8
ENSG00000100429ENST00000349505Q969S8
ENSG00000100429ENST00000415993Q08AP5
ENSG00000100429ENST00000429374Q08AP5
ENSG00000100429ENST00000448072C9J8B8
ENSG00000100429ENST00000454936Q969S8
ENSG00000100429ENST00000626012Q08AP5

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by NOTCH1 in CancerREACTOMER-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in CancerREACTOMER-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain MutantsREACTOMER-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerREACTOMER-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsREACTOMER-HSA-2894862
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDACs deacetylate histonesREACTOMER-HSA-3214815

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
153053722004Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients.67
238017522013Histone deacetylase 10 promotes autophagy-mediated cell survival.56
117393832002Isolation and characterization of a novel class II histone deacetylase, HDAC10.38
238978112013Histone deacetylase (HDAC) 10 suppresses cervical cancer metastasis through inhibition of matrix metalloproteinase (MMP) 2 and 9 expression.38
118619012002Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain.37
212479012011Histone deacetylases 9 and 10 are required for homologous recombination.35
285169542017Histone deacetylase 10 structure and molecular function as a polyamine deacetylase.29
206804882010Inhibition of histone deacetylase 10 induces thioredoxin-interacting protein and causes accumulation of reactive oxygen species in SNU-620 human gastric cancer cells.24
262402842015Histone Deacetylase 10 Regulates the Cell Cycle G2/M Phase Transition via a Novel Let-7-HMGA2-Cyclin A2 Pathway.18

Citation

Dessen P

HDAC10 (histone deacetylase 10)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43706/hdac10