| HDAC4 (2q37.3) / BRAT1 (7p22.3) | HDAC4 (2q37.3) / HDAC4 (2q37.3) | HDAC4 (2q37.3) / NBPF9 (1q21.1) |
|
HDAC4 (2q37.3) / SATB2 (2q33.1) | HDAC4 (2q37.3) / SNX18 (5q11.2) | PPM1F (22q11.22) / HDAC4 (2q37.3) |
|
HDAC4 2q37.3 / BRAT1 7p22.3 | HDAC4 2q37.3 / SATB2 2q33.1 | HDAC4 2q37.3 / SNX18 5q11.2 |
|
| Nomenclature |
HGNC (Hugo) | HDAC4 14063 |
| Cards |
Entrez_Gene (NCBI) | HDAC4 9759 histone deacetylase 4 |
Aliases | AHO3; BDMR; HA6116; HD4; |
| HDAC-4; HDAC-A; HDACA |
GeneCards (Weizmann) | HDAC4 |
Ensembl hg19 (Hinxton) | ENSG00000068024 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000068024 [Gene_View] chr2:239048168-239400949 [Contig_View] HDAC4 [Vega] |
ICGC DataPortal | ENSG00000068024 |
TCGA cBioPortal | HDAC4 |
AceView (NCBI) | HDAC4 |
Genatlas (Paris) | HDAC4 |
WikiGenes | 9759 |
SOURCE (Princeton) | HDAC4 |
Genetics Home Reference (NIH) | HDAC4 |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | HDAC4 - chr2:239048168-239400949 - 2q37.3 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | HDAC4 - 2q37.3 [Description] (hg19-Feb_2009) |
Ensembl | HDAC4 - 2q37.3 [CytoView hg19] HDAC4 - 2q37.3 [CytoView hg38] |
Mapping of homologs : NCBI | HDAC4 [Mapview hg19] HDAC4 [Mapview hg38] |
OMIM | 605314 |
| Gene and transcription |
Genbank (Entrez) | AB006626 AF070607 AF132607 AI199675 AI654062 |
RefSeq transcript (Entrez) | NM_006037 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | HDAC4 |
Cluster EST : Unigene | Hs.20516 [ NCBI ] |
CGAP (NCI) | Hs.20516 |
Alternative Splicing Gallery | ENSG00000068024 |
Gene Expression | HDAC4 [ NCBI-GEO ] HDAC4 [ EBI - ARRAY_EXPRESS ]
HDAC4 [ SEEK ] HDAC4 [ MEM ] |
Gene Expression Viewer (FireBrowse) | HDAC4 [ Firebrowse - Broad ] |
SOURCE (Princeton) | Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60] |
Genevestigator | Expression in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 9759 |
GTEX Portal (Tissue expression) | HDAC4 |
Human Protein Atlas | ENSG00000068024-HDAC4 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | P56524 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | P56524 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | P56524 |
Splice isoforms : SwissVar | P56524 |
PhosPhoSitePlus | P56524 |
Domains : Interpro (EBI) | HDAC4 His_deacetylse His_deacetylse_dom Hist_deacetylase_Gln_rich_N Histone_deAcase_II_euk |
Domain families : Pfam (Sanger) | HDAC4_Gln (PF12203) Hist_deacetyl (PF00850) |
Domain families : Pfam (NCBI) | pfam12203 pfam00850 |
Conserved Domain (NCBI) | HDAC4 |
DMDM Disease mutations | 9759 |
Blocks (Seattle) | HDAC4 |
PDB (SRS) | 2H8N 2O94 2VQJ 2VQM 2VQO 2VQQ 2VQV 2VQW 3UXG 3UZD 3V31 4CBT 4CBY 5A2S |
PDB (PDBSum) | 2H8N 2O94 2VQJ 2VQM 2VQO 2VQQ 2VQV 2VQW 3UXG 3UZD 3V31 4CBT 4CBY 5A2S |
PDB (IMB) | 2H8N 2O94 2VQJ 2VQM 2VQO 2VQQ 2VQV 2VQW 3UXG 3UZD 3V31 4CBT 4CBY 5A2S |
PDB (RSDB) | 2H8N 2O94 2VQJ 2VQM 2VQO 2VQQ 2VQV 2VQW 3UXG 3UZD 3V31 4CBT 4CBY 5A2S |
Structural Biology KnowledgeBase | 2H8N 2O94 2VQJ 2VQM 2VQO 2VQQ 2VQV 2VQW 3UXG 3UZD 3V31 4CBT 4CBY 5A2S |
SCOP (Structural Classification of Proteins) | 2H8N 2O94 2VQJ 2VQM 2VQO 2VQQ 2VQV 2VQW 3UXG 3UZD 3V31 4CBT 4CBY 5A2S |
CATH (Classification of proteins structures) | 2H8N 2O94 2VQJ 2VQM 2VQO 2VQQ 2VQV 2VQW 3UXG 3UZD 3V31 4CBT 4CBY 5A2S |
Superfamily | P56524 |
Human Protein Atlas [tissue] | ENSG00000068024-HDAC4 [tissue] |
Peptide Atlas | P56524 |
HPRD | 05610 |
IPI | IPI00010088 IPI01011861 IPI01012936 IPI00892764 IPI01014711 IPI00892631 IPI00894354 IPI00894491 IPI00892542 |
| Protein Interaction databases |
DIP (DOE-UCLA) | P56524 |
IntAct (EBI) | P56524 |
FunCoup | ENSG00000068024 |
BioGRID | HDAC4 |
STRING (EMBL) | HDAC4 |
ZODIAC | HDAC4 |
| Ontologies - Pathways |
QuickGO | P56524 |
Ontology : AmiGO | histone deacetylase complex negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II core promoter binding RNA polymerase II transcription factor binding skeletal system development osteoblast development transcription corepressor activity histone deacetylase activity protein binding nucleus nucleoplasm nucleoplasm cytoplasm cytosol chromatin remodeling transcription, DNA-templated protein deacetylation inflammatory response nervous system development transcription factor binding zinc ion binding positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of lamellipodium assembly negative regulation of myotube differentiation regulation of cardiac muscle contraction by calcium ion signaling response to denervation involved in regulation of muscle adaptation cardiac muscle hypertrophy in response to stress positive regulation of smooth muscle cell migration histone deacetylation histone deacetylation transcriptional repressor complex protein kinase binding Z disc B cell differentiation potassium ion binding neuromuscular junction A band NAD-dependent histone deacetylase activity (H3-K14 specific) positive regulation of protein sumoylation protein deacetylase activity protein deacetylase activity activating transcription factor binding peptidyl-lysine deacetylation regulation of gene expression, epigenetic B cell activation response to drug actomyosin identical protein binding histone deacetylase binding protein complex regulation of protein binding negative regulation of DNA binding transcription factor activity positive regulation of neuron apoptotic process sequence-specific DNA binding transcription regulatory region DNA binding negative regulation of osteoblast differentiation negative regulation of glycolytic process negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of smooth muscle cell proliferation regulation of skeletal muscle fiber development positive regulation of DNA binding transcription factor activity repressing transcription factor binding response to interleukin-1 histone H3 deacetylation histone H4 deacetylation cellular response to mechanical stimulus cellular response to tumor necrosis factor cellular response to parathyroid hormone stimulus negative regulation of pri-miRNA transcription by RNA polymerase II positive regulation of reactive oxygen species biosynthetic process promoter-specific chromatin binding |
Ontology : EGO-EBI | histone deacetylase complex negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II core promoter binding RNA polymerase II transcription factor binding skeletal system development osteoblast development transcription corepressor activity histone deacetylase activity protein binding nucleus nucleoplasm nucleoplasm cytoplasm cytosol chromatin remodeling transcription, DNA-templated protein deacetylation inflammatory response nervous system development transcription factor binding zinc ion binding positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of lamellipodium assembly negative regulation of myotube differentiation regulation of cardiac muscle contraction by calcium ion signaling response to denervation involved in regulation of muscle adaptation cardiac muscle hypertrophy in response to stress positive regulation of smooth muscle cell migration histone deacetylation histone deacetylation transcriptional repressor complex protein kinase binding Z disc B cell differentiation potassium ion binding neuromuscular junction A band NAD-dependent histone deacetylase activity (H3-K14 specific) positive regulation of protein sumoylation protein deacetylase activity protein deacetylase activity activating transcription factor binding peptidyl-lysine deacetylation regulation of gene expression, epigenetic B cell activation response to drug actomyosin identical protein binding histone deacetylase binding protein complex regulation of protein binding negative regulation of DNA binding transcription factor activity positive regulation of neuron apoptotic process sequence-specific DNA binding transcription regulatory region DNA binding negative regulation of osteoblast differentiation negative regulation of glycolytic process negative regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of smooth muscle cell proliferation regulation of skeletal muscle fiber development positive regulation of DNA binding transcription factor activity repressing transcription factor binding response to interleukin-1 histone H3 deacetylation histone H4 deacetylation cellular response to mechanical stimulus cellular response to tumor necrosis factor cellular response to parathyroid hormone stimulus negative regulation of pri-miRNA transcription by RNA polymerase II positive regulation of reactive oxygen species biosynthetic process promoter-specific chromatin binding |
Pathways : BIOCARTA | Sumoylation by RanBP2 Regulates Transcriptional Repression [Genes] CARM1 and Regulation of the Estrogen Receptor [Genes] |
NDEx Network | HDAC4 |
Atlas of Cancer Signalling Network | HDAC4 |
Wikipedia pathways | HDAC4 |
| Orthology - Evolution |
OrthoDB | 9759 |
GeneTree (enSembl) | ENSG00000068024 |
Phylogenetic Trees/Animal Genes : TreeFam | HDAC4 |
HOVERGEN | P56524 |
HOGENOM | P56524 |
Homologs : HomoloGene | HDAC4 |
Homology/Alignments : Family Browser (UCSC) | HDAC4 |
| Gene fusions - Rearrangements |
Fusion : Mitelman | HDAC4/BRAT1 [2q37.3/7p22.3]   |
Fusion : Mitelman | HDAC4/SATB2 [2q37.3/2q33.1]  [t(2;2)(q33;q37)] |
Fusion : Mitelman | HDAC4/SNX18 [2q37.3/5q11.2]  [t(2;5)(q37;q11)] |
Fusion: TCGA_MDACC | HDAC4 2q37.3 BRAT1 7p22.3 LGG |
Fusion: TCGA_MDACC | HDAC4 2q37.3 SATB2 2q33.1 BLCA |
Fusion: TCGA_MDACC | HDAC4 2q37.3 SNX18 5q11.2 LUAD |
Fusion Portal | HDAC4 2q37.3 BRAT1 7p22.3 LGG |
Fusion Portal | HDAC4 2q37.3 SATB2 2q33.1 BLCA |
Fusion Portal | HDAC4 2q37.3 SNX18 5q11.2 LUAD |
Fusion : Quiver | HDAC4 |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | HDAC4 [hg38] |
dbSNP Single Nucleotide Polymorphism (NCBI) | HDAC4 |
dbVar | HDAC4 |
ClinVar | HDAC4 |
1000_Genomes | HDAC4 |
Exome Variant Server | HDAC4 |
ExAC (Exome Aggregation Consortium) | ENSG00000068024 |
GNOMAD Browser | ENSG00000068024 |
Genetic variants : HAPMAP | 9759 |
Genomic Variants (DGV) | HDAC4 [DGVbeta] |
DECIPHER | HDAC4 [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | HDAC4 |
| Mutations |
ICGC Data Portal | HDAC4 |
TCGA Data Portal | HDAC4 |
Broad Tumor Portal | HDAC4 |
OASIS Portal | HDAC4 [ Somatic mutations - Copy number] |
Somatic Mutations in Cancer : COSMIC | HDAC4 [overview] [genome browser] [tissue] [distribution] |
Mutations and Diseases : HGMD | HDAC4 |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
LOVD (Leiden Open Variation Database) | X-chromosome gene database |
BioMuta | search HDAC4 |
DgiDB (Drug Gene Interaction Database) | HDAC4 |
DoCM (Curated mutations) | HDAC4 (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | HDAC4 (select a term) |
intoGen | HDAC4 |
Cancer3D | HDAC4(select the gene name) |
Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
---|
OMIM | 605314 |
Orphanet | 1313 |
DisGeNET | HDAC4 |
Medgen | HDAC4 |
Genetic Testing Registry | HDAC4
|
NextProt | P56524 [Medical] |
TSGene | 9759 |
GENETests | HDAC4 |
Target Validation | HDAC4 |
Huge Navigator |
HDAC4 [HugePedia] |
snp3D : Map Gene to Disease | 9759 |
BioCentury BCIQ | HDAC4 |
ClinGen | HDAC4 (curated) |
| Clinical trials, drugs, therapy |
---|
Chemical/Protein Interactions : CTD | 9759 |
Chemical/Pharm GKB Gene | PA29229 |
Clinical trial | HDAC4 |
| Miscellaneous |
---|
canSAR (ICR) | HDAC4 (select the gene name) |
| Probes |
---|
| Litterature |
---|
PubMed | 251 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
CoreMine | HDAC4 |
EVEX | HDAC4 |
GoPubMed | HDAC4 |
iHOP | HDAC4 |