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HDAC7 (histone deacetylase 7)

Identity

Alias_namesHDAC7A
histone deacetylase 7A
Alias_symbol (synonym)DKFZP586J0917
Other aliasHD7
HD7A
HGNC (Hugo) HDAC7
LocusID (NCBI) 51564
Atlas_Id 46734
Location 12q13.11  [Link to chromosome band 12q13]
Location_base_pair Starts at 47782711 and ends at 47819980 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EVC2 (4p16.2) / HDAC7 (12q13.11)HDAC7 (12q13.11) / CHUK (10q24.31)HDAC7 (12q13.11) / HDAC7 (12q13.11)
HDAC7 (12q13.11) / IRAK4 (12q12)HDAC7 (12q13.11) / VEPH1 (3q25.31)TBC1D17 (19q13.33) / HDAC7 (12q13.11)
HDAC7 12q13.11 / IRAK4 12q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(12;12)(q12;q13) HDAC7/IRAK4
HDAC7/VDR (12q13)


External links

Nomenclature
HGNC (Hugo)HDAC7   14067
Cards
Entrez_Gene (NCBI)HDAC7  51564  histone deacetylase 7
AliasesHD7; HD7A; HDAC7A
GeneCards (Weizmann)HDAC7
Ensembl hg19 (Hinxton)ENSG00000061273 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000061273 [Gene_View]  ENSG00000061273 [Sequence]  chr12:47782711-47819980 [Contig_View]  HDAC7 [Vega]
ICGC DataPortalENSG00000061273
TCGA cBioPortalHDAC7
AceView (NCBI)HDAC7
Genatlas (Paris)HDAC7
WikiGenes51564
SOURCE (Princeton)HDAC7
Genetics Home Reference (NIH)HDAC7
Genomic and cartography
GoldenPath hg38 (UCSC)HDAC7  -     chr12:47782711-47819980 -  12q13.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HDAC7  -     12q13.11   [Description]    (hg19-Feb_2009)
EnsemblHDAC7 - 12q13.11 [CytoView hg19]  HDAC7 - 12q13.11 [CytoView hg38]
Mapping of homologs : NCBIHDAC7 [Mapview hg19]  HDAC7 [Mapview hg38]
OMIM606542   
Gene and transcription
Genbank (Entrez)AF239243 AK001032 AK001190 AK024387 AK024469
RefSeq transcript (Entrez)NM_001098416 NM_001308090 NM_015401 NM_016596
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HDAC7
Cluster EST : UnigeneHs.200063 [ NCBI ]
CGAP (NCI)Hs.200063
Alternative Splicing GalleryENSG00000061273
Gene ExpressionHDAC7 [ NCBI-GEO ]   HDAC7 [ EBI - ARRAY_EXPRESS ]   HDAC7 [ SEEK ]   HDAC7 [ MEM ]
Gene Expression Viewer (FireBrowse)HDAC7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51564
GTEX Portal (Tissue expression)HDAC7
Human Protein AtlasENSG00000061273-HDAC7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WUI4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WUI4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WUI4
Splice isoforms : SwissVarQ8WUI4
Catalytic activity : Enzyme3.5.1.98 [ Enzyme-Expasy ]   3.5.1.983.5.1.98 [ IntEnz-EBI ]   3.5.1.98 [ BRENDA ]   3.5.1.98 [ KEGG ]   
PhosPhoSitePlusQ8WUI4
Domains : Interpro (EBI)His_deacetylse    His_deacetylse_dom    His_deacetylse_dom_sf    Histone_deAcase_II_euk    Ureohydrolase_dom_sf   
Domain families : Pfam (Sanger)Hist_deacetyl (PF00850)   
Domain families : Pfam (NCBI)pfam00850   
Conserved Domain (NCBI)HDAC7
DMDM Disease mutations51564
Blocks (Seattle)HDAC7
PDB (SRS)3C0Y    3C0Z    3C10    3ZNR    3ZNS   
PDB (PDBSum)3C0Y    3C0Z    3C10    3ZNR    3ZNS   
PDB (IMB)3C0Y    3C0Z    3C10    3ZNR    3ZNS   
PDB (RSDB)3C0Y    3C0Z    3C10    3ZNR    3ZNS   
Structural Biology KnowledgeBase3C0Y    3C0Z    3C10    3ZNR    3ZNS   
SCOP (Structural Classification of Proteins)3C0Y    3C0Z    3C10    3ZNR    3ZNS   
CATH (Classification of proteins structures)3C0Y    3C0Z    3C10    3ZNR    3ZNS   
SuperfamilyQ8WUI4
Human Protein Atlas [tissue]ENSG00000061273-HDAC7 [tissue]
Peptide AtlasQ8WUI4
HPRD09133
IPIIPI00743474   IPI00944518   IPI00306189   IPI00917034   IPI00386808   IPI00916348   IPI00916810   IPI00916470   IPI00909569   IPI00944634   IPI00386149   IPI01021992   IPI01020891   IPI01025119   IPI01020789   IPI00916633   IPI00916795   IPI00418482   IPI00917355   IPI00916377   IPI00916494   IPI01017881   IPI00916978   IPI00917167   IPI00917256   
Protein Interaction databases
DIP (DOE-UCLA)Q8WUI4
IntAct (EBI)Q8WUI4
FunCoupENSG00000061273
BioGRIDHDAC7
STRING (EMBL)HDAC7
ZODIACHDAC7
Ontologies - Pathways
QuickGOQ8WUI4
Ontology : AmiGOhistone deacetylase complex  negative regulation of transcription by RNA polymerase II  vasculogenesis  chromatin binding  transcription corepressor activity  protein kinase C binding  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  cell-cell junction assembly  protein sumoylation  SUMO transferase activity  protein kinase binding  NAD-dependent histone deacetylase activity (H3-K14 specific)  negative regulation of interleukin-2 production  activating transcription factor binding  negative regulation of osteoblast differentiation  metal ion binding  repressing transcription factor binding  histone H3 deacetylation  14-3-3 protein binding  positive regulation of cell migration involved in sprouting angiogenesis  negative regulation of NIK/NF-kappaB signaling  
Ontology : EGO-EBIhistone deacetylase complex  negative regulation of transcription by RNA polymerase II  vasculogenesis  chromatin binding  transcription corepressor activity  protein kinase C binding  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  cell-cell junction assembly  protein sumoylation  SUMO transferase activity  protein kinase binding  NAD-dependent histone deacetylase activity (H3-K14 specific)  negative regulation of interleukin-2 production  activating transcription factor binding  negative regulation of osteoblast differentiation  metal ion binding  repressing transcription factor binding  histone H3 deacetylation  14-3-3 protein binding  positive regulation of cell migration involved in sprouting angiogenesis  negative regulation of NIK/NF-kappaB signaling  
Pathways : KEGGAlcoholism    Viral carcinogenesis   
NDEx NetworkHDAC7
Atlas of Cancer Signalling NetworkHDAC7
Wikipedia pathwaysHDAC7
Orthology - Evolution
OrthoDB51564
GeneTree (enSembl)ENSG00000061273
Phylogenetic Trees/Animal Genes : TreeFamHDAC7
HOVERGENQ8WUI4
HOGENOMQ8WUI4
Homologs : HomoloGeneHDAC7
Homology/Alignments : Family Browser (UCSC)HDAC7
Gene fusions - Rearrangements
Fusion : MitelmanHDAC7/IRAK4 [12q13.11/12q12]  
Fusion PortalHDAC7 12q13.11 IRAK4 12q12 BRCA
Fusion : QuiverHDAC7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHDAC7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HDAC7
dbVarHDAC7
ClinVarHDAC7
1000_GenomesHDAC7 
Exome Variant ServerHDAC7
ExAC (Exome Aggregation Consortium)ENSG00000061273
GNOMAD BrowserENSG00000061273
Varsome BrowserHDAC7
Genetic variants : HAPMAP51564
Genomic Variants (DGV)HDAC7 [DGVbeta]
DECIPHERHDAC7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHDAC7 
Mutations
ICGC Data PortalHDAC7 
TCGA Data PortalHDAC7 
Broad Tumor PortalHDAC7
OASIS PortalHDAC7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHDAC7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHDAC7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HDAC7
DgiDB (Drug Gene Interaction Database)HDAC7
DoCM (Curated mutations)HDAC7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HDAC7 (select a term)
intoGenHDAC7
Cancer3DHDAC7(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606542   
Orphanet
DisGeNETHDAC7
MedgenHDAC7
Genetic Testing Registry HDAC7
NextProtQ8WUI4 [Medical]
TSGene51564
GENETestsHDAC7
Target ValidationHDAC7
Huge Navigator HDAC7 [HugePedia]
snp3D : Map Gene to Disease51564
BioCentury BCIQHDAC7
ClinGenHDAC7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51564
Chemical/Pharm GKB GenePA162390579
Clinical trialHDAC7
Miscellaneous
canSAR (ICR)HDAC7 (select the gene name)
Probes
Litterature
PubMed108 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHDAC7
EVEXHDAC7
GoPubMedHDAC7
iHOPHDAC7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:10:23 CET 2018

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