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HDAC8 (histone deacetylase 8)

Identity

Alias_namesHDACL1
WTS
MRXS6
histone deacetylase-like 1
Wilson-Turner X-linked mental retardation syndrome
Alias_symbol (synonym)RPD3
Other aliasCDA07
CDLS5
HD8
HGNC (Hugo) HDAC8
LocusID (NCBI) 55869
Atlas_Id 46856
Location Xq13.1  [Link to chromosome band Xq13]
Location_base_pair Starts at 71549366 and ends at 71792953 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AXIN1 (16p13.3) / HDAC8 (Xq13.1)GPI (19q13.11) / HDAC8 (Xq13.1)HDAC8 (Xq13.1) / CITED1 (Xq13.1)
HDAC8 (Xq13.1) / NDUFS2 (1q23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HDAC8   13315
Cards
Entrez_Gene (NCBI)HDAC8  55869  histone deacetylase 8
AliasesCDA07; CDLS5; HD8; HDACL1; 
MRXS6; RPD3; WTS
GeneCards (Weizmann)HDAC8
Ensembl hg19 (Hinxton)ENSG00000147099 [Gene_View]  chrX:71549366-71792953 [Contig_View]  HDAC8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000147099 [Gene_View]  chrX:71549366-71792953 [Contig_View]  HDAC8 [Vega]
ICGC DataPortalENSG00000147099
TCGA cBioPortalHDAC8
AceView (NCBI)HDAC8
Genatlas (Paris)HDAC8
WikiGenes55869
SOURCE (Princeton)HDAC8
Genetics Home Reference (NIH)HDAC8
Genomic and cartography
GoldenPath hg19 (UCSC)HDAC8  -     chrX:71549366-71792953 -  Xq13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HDAC8  -     Xq13.1   [Description]    (hg38-Dec_2013)
EnsemblHDAC8 - Xq13.1 [CytoView hg19]  HDAC8 - Xq13.1 [CytoView hg38]
Mapping of homologs : NCBIHDAC8 [Mapview hg19]  HDAC8 [Mapview hg38]
OMIM300269   
Gene and transcription
Genbank (Entrez)AF212246 AF230097 AF245664 AI651236 AI916593
RefSeq transcript (Entrez)NM_001166418 NM_001166419 NM_001166420 NM_001166422 NM_001166448 NM_018486
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_015851 NT_011651 NW_004929443
Consensus coding sequences : CCDS (NCBI)HDAC8
Cluster EST : UnigeneHs.310536 [ NCBI ]
CGAP (NCI)Hs.310536
Alternative Splicing GalleryENSG00000147099
Gene ExpressionHDAC8 [ NCBI-GEO ]   HDAC8 [ EBI - ARRAY_EXPRESS ]   HDAC8 [ SEEK ]   HDAC8 [ MEM ]
Gene Expression Viewer (FireBrowse)HDAC8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55869
GTEX Portal (Tissue expression)HDAC8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BY41   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BY41  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BY41
Splice isoforms : SwissVarQ9BY41
PhosPhoSitePlusQ9BY41
Domains : Interpro (EBI)His_deacetylse    His_deacetylse_1    His_deacetylse_dom   
Domain families : Pfam (Sanger)Hist_deacetyl (PF00850)   
Domain families : Pfam (NCBI)pfam00850   
Conserved Domain (NCBI)HDAC8
DMDM Disease mutations55869
Blocks (Seattle)HDAC8
PDB (SRS)1T64    1T67    1T69    1VKG    1W22    2V5W    2V5X    3EW8    3EWF    3EZP    3EZT    3F06    3F07    3F0R    3MZ3    3MZ4    3MZ6    3MZ7    3RQD    3SFF    3SFH    4QA0    4QA1    4QA2    4QA3    4QA4    4QA5    4QA6    4QA7    4RN0    4RN1    4RN2    5D1B    5D1C    5D1D    5DC5    5DC6    5DC7    5DC8   
PDB (PDBSum)1T64    1T67    1T69    1VKG    1W22    2V5W    2V5X    3EW8    3EWF    3EZP    3EZT    3F06    3F07    3F0R    3MZ3    3MZ4    3MZ6    3MZ7    3RQD    3SFF    3SFH    4QA0    4QA1    4QA2    4QA3    4QA4    4QA5    4QA6    4QA7    4RN0    4RN1    4RN2    5D1B    5D1C    5D1D    5DC5    5DC6    5DC7    5DC8   
PDB (IMB)1T64    1T67    1T69    1VKG    1W22    2V5W    2V5X    3EW8    3EWF    3EZP    3EZT    3F06    3F07    3F0R    3MZ3    3MZ4    3MZ6    3MZ7    3RQD    3SFF    3SFH    4QA0    4QA1    4QA2    4QA3    4QA4    4QA5    4QA6    4QA7    4RN0    4RN1    4RN2    5D1B    5D1C    5D1D    5DC5    5DC6    5DC7    5DC8   
PDB (RSDB)1T64    1T67    1T69    1VKG    1W22    2V5W    2V5X    3EW8    3EWF    3EZP    3EZT    3F06    3F07    3F0R    3MZ3    3MZ4    3MZ6    3MZ7    3RQD    3SFF    3SFH    4QA0    4QA1    4QA2    4QA3    4QA4    4QA5    4QA6    4QA7    4RN0    4RN1    4RN2    5D1B    5D1C    5D1D    5DC5    5DC6    5DC7    5DC8   
Structural Biology KnowledgeBase1T64    1T67    1T69    1VKG    1W22    2V5W    2V5X    3EW8    3EWF    3EZP    3EZT    3F06    3F07    3F0R    3MZ3    3MZ4    3MZ6    3MZ7    3RQD    3SFF    3SFH    4QA0    4QA1    4QA2    4QA3    4QA4    4QA5    4QA6    4QA7    4RN0    4RN1    4RN2    5D1B    5D1C    5D1D    5DC5    5DC6    5DC7    5DC8   
SCOP (Structural Classification of Proteins)1T64    1T67    1T69    1VKG    1W22    2V5W    2V5X    3EW8    3EWF    3EZP    3EZT    3F06    3F07    3F0R    3MZ3    3MZ4    3MZ6    3MZ7    3RQD    3SFF    3SFH    4QA0    4QA1    4QA2    4QA3    4QA4    4QA5    4QA6    4QA7    4RN0    4RN1    4RN2    5D1B    5D1C    5D1D    5DC5    5DC6    5DC7    5DC8   
CATH (Classification of proteins structures)1T64    1T67    1T69    1VKG    1W22    2V5W    2V5X    3EW8    3EWF    3EZP    3EZT    3F06    3F07    3F0R    3MZ3    3MZ4    3MZ6    3MZ7    3RQD    3SFF    3SFH    4QA0    4QA1    4QA2    4QA3    4QA4    4QA5    4QA6    4QA7    4RN0    4RN1    4RN2    5D1B    5D1C    5D1D    5DC5    5DC6    5DC7    5DC8   
SuperfamilyQ9BY41
Human Protein AtlasENSG00000147099
Peptide AtlasQ9BY41
HPRD02227
IPIIPI00747259   IPI00245706   IPI00515065   IPI00877629   IPI00940536   IPI01018767   IPI00645124   IPI00647323   IPI00645419   IPI00941989   IPI00642981   IPI00642258   IPI00878343   IPI00644421   IPI00641848   IPI01017920   IPI00880109   IPI00940139   
Protein Interaction databases
DIP (DOE-UCLA)Q9BY41
IntAct (EBI)Q9BY41
FunCoupENSG00000147099
BioGRIDHDAC8
STRING (EMBL)HDAC8
ZODIACHDAC8
Ontologies - Pathways
QuickGOQ9BY41
Ontology : AmiGOhistone deacetylase complex  negative regulation of transcription from RNA polymerase II promoter  nuclear chromosome  histone deacetylase activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  plasma membrane  chromatin assembly or disassembly  transcription, DNA-templated  sister chromatid cohesion  transcription factor binding  chromatin modification  Hsp70 protein binding  negative regulation of protein ubiquitination  regulation of protein stability  NAD-dependent histone deacetylase activity (H3-K14 specific)  regulation of telomere maintenance  metal ion binding  Hsp90 protein binding  histone H3 deacetylation  regulation of cohesin localization to chromatin  
Ontology : EGO-EBIhistone deacetylase complex  negative regulation of transcription from RNA polymerase II promoter  nuclear chromosome  histone deacetylase activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  plasma membrane  chromatin assembly or disassembly  transcription, DNA-templated  sister chromatid cohesion  transcription factor binding  chromatin modification  Hsp70 protein binding  negative regulation of protein ubiquitination  regulation of protein stability  NAD-dependent histone deacetylase activity (H3-K14 specific)  regulation of telomere maintenance  metal ion binding  Hsp90 protein binding  histone H3 deacetylation  regulation of cohesin localization to chromatin  
Pathways : KEGGAlcoholism    Viral carcinogenesis   
NDEx NetworkHDAC8
Atlas of Cancer Signalling NetworkHDAC8
Wikipedia pathwaysHDAC8
Orthology - Evolution
OrthoDB55869
GeneTree (enSembl)ENSG00000147099
Phylogenetic Trees/Animal Genes : TreeFamHDAC8
HOVERGENQ9BY41
HOGENOMQ9BY41
Homologs : HomoloGeneHDAC8
Homology/Alignments : Family Browser (UCSC)HDAC8
Gene fusions - Rearrangements
Fusion : MitelmanHDAC8/CITED1 [Xq13.1/Xq13.1]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHDAC8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HDAC8
dbVarHDAC8
ClinVarHDAC8
1000_GenomesHDAC8 
Exome Variant ServerHDAC8
ExAC (Exome Aggregation Consortium)HDAC8 (select the gene name)
Genetic variants : HAPMAP55869
Genomic Variants (DGV)HDAC8 [DGVbeta]
DECIPHER (Syndromes)X:71549366-71792953  ENSG00000147099
CONAN: Copy Number AnalysisHDAC8 
Mutations
ICGC Data PortalHDAC8 
TCGA Data PortalHDAC8 
Broad Tumor PortalHDAC8
OASIS PortalHDAC8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHDAC8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHDAC8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch HDAC8
DgiDB (Drug Gene Interaction Database)HDAC8
DoCM (Curated mutations)HDAC8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HDAC8 (select a term)
intoGenHDAC8
Cancer3DHDAC8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300269   
Orphanet299    3041   
MedgenHDAC8
Genetic Testing Registry HDAC8
NextProtQ9BY41 [Medical]
TSGene55869
GENETestsHDAC8
Huge Navigator HDAC8 [HugePedia]
snp3D : Map Gene to Disease55869
BioCentury BCIQHDAC8
ClinGenHDAC8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55869
Chemical/Pharm GKB GenePA37766
Clinical trialHDAC8
Miscellaneous
canSAR (ICR)HDAC8 (select the gene name)
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHDAC8
EVEXHDAC8
GoPubMedHDAC8
iHOPHDAC8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:08:45 CET 2017

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