Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HDAC9 (histone deacetylase 9)

Identity

Other namesHD7
HD7b
HD9
HDAC
HDAC7
HDAC7B
HDAC9B
HDAC9FL
HDRP
MITR
HGNC (Hugo) HDAC9
LocusID (NCBI) 9734
Location 7p21.1
Location_base_pair Starts at 18126572 and ends at 18708466 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors AmeloblastomID5945

External links

Nomenclature
HGNC (Hugo)HDAC9   14065
Cards
Entrez_Gene (NCBI)HDAC9  9734  histone deacetylase 9
GeneCards (Weizmann)HDAC9
Ensembl (Hinxton)ENSG00000048052 [Gene_View]  chr7:18126572-18708466 [Contig_View]  HDAC9 [Vega]
ICGC DataPortalENSG00000048052
cBioPortalHDAC9
AceView (NCBI)HDAC9
Genatlas (Paris)HDAC9
WikiGenes9734
SOURCE (Princeton)NM_001204144 NM_001204145 NM_001204146 NM_001204147 NM_001204148 NM_014707 NM_058176 NM_058177 NM_178423 NM_178425
Genomic and cartography
GoldenPath (UCSC)HDAC9  -  7p21.1   chr7:18126572-18708466 +  7p21.1   [Description]    (hg19-Feb_2009)
EnsemblHDAC9 - 7p21.1 [CytoView]
Mapping of homologs : NCBIHDAC9 [Mapview]
OMIM606543   
Gene and transcription
Genbank (Entrez)AA405905 AB018287 AF124924 AJ459808 AK095820
RefSeq transcript (Entrez)NM_001204144 NM_001204145 NM_001204146 NM_001204147 NM_001204148 NM_014707 NM_058176 NM_058177 NM_178423 NM_178425
RefSeq genomic (Entrez)AC_000139 NC_000007 NC_018918 NG_023250 NT_007819 NW_001839003 NW_004929329
Consensus coding sequences : CCDS (NCBI)HDAC9
Cluster EST : UnigeneHs.196054 [ NCBI ]
CGAP (NCI)Hs.196054
Alternative Splicing : Fast-db (Paris)GSHG0027183
Alternative Splicing GalleryENSG00000048052
Gene ExpressionHDAC9 [ NCBI-GEO ]     HDAC9 [ SEEK ]   HDAC9 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKV0 (Uniprot)
NextProtQ9UKV0  [Medical]
With graphics : InterProQ9UKV0
Splice isoforms : SwissVarQ9UKV0 (Swissvar)
Catalytic activity : Enzyme3.5.1.98 [ Enzyme-Expasy ]   3.5.1.983.5.1.98 [ IntEnz-EBI ]   3.5.1.98 [ BRENDA ]   3.5.1.98 [ KEGG ]   
Domains : Interpro (EBI)His_deacetylse [organisation]   His_deacetylse_dom [organisation]   Hist_deacetylase_Gln_rich_N [organisation]   Histone_deAcase_II_euk [organisation]  
Related proteins : CluSTrQ9UKV0
Domain families : Pfam (Sanger)HDAC4_Gln (PF12203)    Hist_deacetyl (PF00850)   
Domain families : Pfam (NCBI)pfam12203    pfam00850   
DMDM Disease mutations9734
Blocks (Seattle)Q9UKV0
Human Protein AtlasENSG00000048052 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ9UKV0
HPRD05944
IPIIPI00232519   IPI00215728   IPI00215729   IPI00215730   IPI00829837   IPI00829883   IPI00328781   IPI00974086   IPI00974194   IPI00894548   IPI00894305   IPI00894119   IPI00893998   IPI00983752   IPI00893751   IPI00980189   IPI00893441   IPI01011786   IPI00936847   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKV0
IntAct (EBI)Q9UKV0
FunCoupENSG00000048052
BioGRIDHDAC9
InParanoidQ9UKV0
Interologous Interaction database Q9UKV0
IntegromeDBHDAC9
STRING (EMBL)HDAC9
Ontologies - Pathways
Ontology : AmiGOhistone deacetylase complex  negative regulation of transcription from RNA polymerase II promoter  transcription corepressor activity  histone deacetylase activity  histone deacetylase activity  protein kinase C binding  protein binding  nucleus  nucleoplasm  transcription factor complex  cytoplasm  cytoplasm  transcription, DNA-templated  inflammatory response  Notch signaling pathway  heart development  transcription factor binding  transcription factor binding  histone deacetylation  B cell differentiation  NAD-dependent histone deacetylase activity (H3-K14 specific)  cellular response to insulin stimulus  protein deacetylase activity  peptidyl-lysine deacetylation  histone methyltransferase complex  B cell activation  histone deacetylase binding  histone deacetylase binding  negative regulation of transcription, DNA-templated  metal ion binding  NAD-dependent histone deacetylase activity (H3-K9 specific)  NAD-dependent histone deacetylase activity (H4-K16 specific)  regulation of skeletal muscle fiber development  regulation of striated muscle cell differentiation  repressing transcription factor binding  repressing transcription factor binding  repressing transcription factor binding  histone H3 deacetylation  histone H4 deacetylation  positive regulation of cell migration involved in sprouting angiogenesis  NAD-dependent histone deacetylase activity (H3-K18 specific)  
Ontology : EGO-EBIhistone deacetylase complex  negative regulation of transcription from RNA polymerase II promoter  transcription corepressor activity  histone deacetylase activity  histone deacetylase activity  protein kinase C binding  protein binding  nucleus  nucleoplasm  transcription factor complex  cytoplasm  cytoplasm  transcription, DNA-templated  inflammatory response  Notch signaling pathway  heart development  transcription factor binding  transcription factor binding  histone deacetylation  B cell differentiation  NAD-dependent histone deacetylase activity (H3-K14 specific)  cellular response to insulin stimulus  protein deacetylase activity  peptidyl-lysine deacetylation  histone methyltransferase complex  B cell activation  histone deacetylase binding  histone deacetylase binding  negative regulation of transcription, DNA-templated  metal ion binding  NAD-dependent histone deacetylase activity (H3-K9 specific)  NAD-dependent histone deacetylase activity (H4-K16 specific)  regulation of skeletal muscle fiber development  regulation of striated muscle cell differentiation  repressing transcription factor binding  repressing transcription factor binding  repressing transcription factor binding  histone H3 deacetylation  histone H4 deacetylation  positive regulation of cell migration involved in sprouting angiogenesis  NAD-dependent histone deacetylase activity (H3-K18 specific)  
Pathways : BIOCARTASumoylation by RanBP2 Regulates Transcriptional Repression [Genes]    Signal Dependent Regulation of Myogenesis by Corepressor MITR [Genes]   
Pathways : KEGGAlcoholism    Viral carcinogenesis   
Protein Interaction DatabaseHDAC9
Wikipedia pathwaysHDAC9
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)HDAC9
snp3D : Map Gene to Disease9734
SNP (GeneSNP Utah)HDAC9
SNP : HGBaseHDAC9
Genetic variants : HAPMAPHDAC9
Exome VariantHDAC9
1000_GenomesHDAC9 
ICGC programENSG00000048052 
Somatic Mutations in Cancer : COSMICHDAC9 
CONAN: Copy Number AnalysisHDAC9 
Mutations and Diseases : HGMDHDAC9
Mutations and Diseases : intOGenHDAC9
Genomic VariantsHDAC9  HDAC9 [DGVbeta]
dbVarHDAC9
ClinVarHDAC9
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM606543   
MedgenHDAC9
GENETestsHDAC9
Disease Genetic AssociationHDAC9
Huge Navigator HDAC9 [HugePedia]  HDAC9 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneHDAC9
Homology/Alignments : Family Browser (UCSC)HDAC9
Phylogenetic Trees/Animal Genes : TreeFamHDAC9
Chemical/Protein Interactions : CTD9734
Chemical/Pharm GKB GenePA38377
Clinical trialHDAC9
Cancer Resource (Charite)ENSG00000048052
Other databases
Probes
Litterature
PubMed95 Pubmed reference(s) in Entrez
CoreMineHDAC9
iHOPHDAC9
OncoSearchHDAC9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:49:13 CEST 2014

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