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HDDC3 (HD domain containing 3)

Identity

Alias_symbol (synonym)MGC45386
Other alias(ppGpp)ase
MESH1
HGNC (Hugo) HDDC3
LocusID (NCBI) 374659
Atlas_Id 64214
Location 15q26.1  [Link to chromosome band 15q26]
Location_base_pair Starts at 90930918 and ends at 90932569 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SLCO3A1 (15q26.1) / HDDC3 (15q26.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HDDC3   30522
Cards
Entrez_Gene (NCBI)HDDC3  374659  HD domain containing 3
Aliases(ppGpp)ase; MESH1
GeneCards (Weizmann)HDDC3
Ensembl hg19 (Hinxton)ENSG00000184508 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184508 [Gene_View]  chr15:90930918-90932569 [Contig_View]  HDDC3 [Vega]
ICGC DataPortalENSG00000184508
TCGA cBioPortalHDDC3
AceView (NCBI)HDDC3
Genatlas (Paris)HDDC3
WikiGenes374659
SOURCE (Princeton)HDDC3
Genetics Home Reference (NIH)HDDC3
Genomic and cartography
GoldenPath hg38 (UCSC)HDDC3  -     chr15:90930918-90932569 -  15q26.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HDDC3  -     15q26.1   [Description]    (hg19-Feb_2009)
EnsemblHDDC3 - 15q26.1 [CytoView hg19]  HDDC3 - 15q26.1 [CytoView hg38]
Mapping of homologs : NCBIHDDC3 [Mapview hg19]  HDDC3 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK057584 AW138983 BC033794 BQ777217 BU633661
RefSeq transcript (Entrez)NM_001286451 NM_198527
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HDDC3
Cluster EST : UnigeneHs.349979 [ NCBI ]
CGAP (NCI)Hs.349979
Alternative Splicing GalleryENSG00000184508
Gene ExpressionHDDC3 [ NCBI-GEO ]   HDDC3 [ EBI - ARRAY_EXPRESS ]   HDDC3 [ SEEK ]   HDDC3 [ MEM ]
Gene Expression Viewer (FireBrowse)HDDC3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)374659
GTEX Portal (Tissue expression)HDDC3
Human Protein AtlasENSG00000184508-HDDC3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N4P3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N4P3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N4P3
Splice isoforms : SwissVarQ8N4P3
Catalytic activity : Enzyme3.1.7.2 [ Enzyme-Expasy ]   3.1.7.23.1.7.2 [ IntEnz-EBI ]   3.1.7.2 [ BRENDA ]   3.1.7.2 [ KEGG ]   
PhosPhoSitePlusQ8N4P3
Domains : Interpro (EBI)HD/PDEase_dom    HD_domain   
Domain families : Pfam (Sanger)HD_4 (PF13328)   
Domain families : Pfam (NCBI)pfam13328   
Domain families : Smart (EMBL)HDc (SM00471)  
Conserved Domain (NCBI)HDDC3
DMDM Disease mutations374659
Blocks (Seattle)HDDC3
PDB (SRS)3NR1   
PDB (PDBSum)3NR1   
PDB (IMB)3NR1   
PDB (RSDB)3NR1   
Structural Biology KnowledgeBase3NR1   
SCOP (Structural Classification of Proteins)3NR1   
CATH (Classification of proteins structures)3NR1   
SuperfamilyQ8N4P3
Human Protein Atlas [tissue]ENSG00000184508-HDDC3 [tissue]
Peptide AtlasQ8N4P3
HPRD14635
IPIIPI00789618   IPI00394782   IPI00975500   
Protein Interaction databases
DIP (DOE-UCLA)Q8N4P3
IntAct (EBI)Q8N4P3
FunCoupENSG00000184508
BioGRIDHDDC3
STRING (EMBL)HDDC3
ZODIACHDDC3
Ontologies - Pathways
QuickGOQ8N4P3
Ontology : AmiGOprotein binding  guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity  metal ion binding  
Ontology : EGO-EBIprotein binding  guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity  metal ion binding  
Pathways : KEGGPurine metabolism   
NDEx NetworkHDDC3
Atlas of Cancer Signalling NetworkHDDC3
Wikipedia pathwaysHDDC3
Orthology - Evolution
OrthoDB374659
GeneTree (enSembl)ENSG00000184508
Phylogenetic Trees/Animal Genes : TreeFamHDDC3
HOVERGENQ8N4P3
HOGENOMQ8N4P3
Homologs : HomoloGeneHDDC3
Homology/Alignments : Family Browser (UCSC)HDDC3
Gene fusions - Rearrangements
Fusion: Tumor Portal HDDC3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHDDC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HDDC3
dbVarHDDC3
ClinVarHDDC3
1000_GenomesHDDC3 
Exome Variant ServerHDDC3
ExAC (Exome Aggregation Consortium)ENSG00000184508
GNOMAD BrowserENSG00000184508
Genetic variants : HAPMAP374659
Genomic Variants (DGV)HDDC3 [DGVbeta]
DECIPHERHDDC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHDDC3 
Mutations
ICGC Data PortalHDDC3 
TCGA Data PortalHDDC3 
Broad Tumor PortalHDDC3
OASIS PortalHDDC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHDDC3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHDDC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HDDC3
DgiDB (Drug Gene Interaction Database)HDDC3
DoCM (Curated mutations)HDDC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HDDC3 (select a term)
intoGenHDDC3
Cancer3DHDDC3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenHDDC3
Genetic Testing Registry HDDC3
NextProtQ8N4P3 [Medical]
TSGene374659
GENETestsHDDC3
Target ValidationHDDC3
Huge Navigator HDDC3 [HugePedia]
snp3D : Map Gene to Disease374659
BioCentury BCIQHDDC3
ClinGenHDDC3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD374659
Chemical/Pharm GKB GenePA142671696
Clinical trialHDDC3
Miscellaneous
canSAR (ICR)HDDC3 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHDDC3
EVEXHDDC3
GoPubMedHDDC3
iHOPHDDC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 11:50:21 CET 2017

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