HDGF (heparin binding growth factor)

2003-02-01  

Identity

HGNC
HDGF
LOCATION
1q23.1
LOCUSID
3068
ALIAS
HMG1L2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3068
MIM: 600339
HGNC: 4856
Ensembl: ENSG00000143321

Variants:

dbSNP: 3068
ClinVar: 3068
TCGA: ENSG00000143321
COSMIC: HDGF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143321ENST00000357325P51858
ENSG00000143321ENST00000357325A0A384NPW1
ENSG00000143321ENST00000368206P51858
ENSG00000143321ENST00000368209P51858
ENSG00000143321ENST00000537739P51858
ENSG00000143321ENST00000537739A0A384NPW1

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
117518702002Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus by nuclear localization signals.37
236732962013Downregulation of miR-497 promotes tumor growth and angiogenesis by targeting HDGF in non-small cell lung cancer.35
170626792006Hepatoma-derived growth factor is a novel prognostic factor for patients with pancreatic cancer.33
239542932013Downregulation of miR-16 promotes growth and motility by targeting HDGF in non-small cell lung cancer cells.31
223317962012Differential proteomic analysis of human glioblastoma and neural stem cells reveals HDGF as a novel angiogenic secreted factor.29
179740292007Hepatoma-derived growth factor binds DNA through the N-terminal PWWP domain.27
191441562009Combined use of expression and CGH arrays pinpoints novel candidate genes in Ewing sarcoma family of tumors.26
147518522004Hepatoma-derived growth factor is a pulmonary endothelial cell-expressed angiogenic factor.25
248911872014MiR-195 targets HDGF to inhibit proliferation and invasion of NSCLC cells.23
222470692012Hepatoma-derived growth factor regulates breast cancer cell invasion by modulating epithelial--mesenchymal transition.19

Citation

Dessen P

HDGF (heparin binding growth factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40809/hdgf