Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HEBP2 (heme binding protein 2)

Identity

Other aliasC6ORF34B
C6orf34
PP23
SOUL
HGNC (Hugo) HEBP2
LocusID (NCBI) 23593
Atlas_Id 57082
Location 6q24.1  [Link to chromosome band 6q24]
Location_base_pair Starts at 138404199 and ends at 138413445 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HEBP2 (6q23.3) / JMJD1C (10q21.3)VTA1 (6q24.1) / HEBP2 (6q23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HEBP2   15716
Cards
Entrez_Gene (NCBI)HEBP2  23593  heme binding protein 2
AliasesC6ORF34B; C6orf34; PP23; SOUL
GeneCards (Weizmann)HEBP2
Ensembl hg19 (Hinxton)ENSG00000051620 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000051620 [Gene_View]  ENSG00000051620 [Sequence]  chr6:138404199-138413445 [Contig_View]  HEBP2 [Vega]
ICGC DataPortalENSG00000051620
TCGA cBioPortalHEBP2
AceView (NCBI)HEBP2
Genatlas (Paris)HEBP2
WikiGenes23593
SOURCE (Princeton)HEBP2
Genetics Home Reference (NIH)HEBP2
Genomic and cartography
GoldenPath hg38 (UCSC)HEBP2  -     chr6:138404199-138413445 +  6q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HEBP2  -     6q24.1   [Description]    (hg19-Feb_2009)
EnsemblHEBP2 - 6q24.1 [CytoView hg19]  HEBP2 - 6q24.1 [CytoView hg38]
Mapping of homologs : NCBIHEBP2 [Mapview hg19]  HEBP2 [Mapview hg38]
OMIM605825   
Gene and transcription
Genbank (Entrez)AF117616 AF411610 AK057928 AY427823 BC008205
RefSeq transcript (Entrez)NM_001326380 NM_001326381 NM_014320
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HEBP2
Cluster EST : UnigeneHs.486589 [ NCBI ]
CGAP (NCI)Hs.486589
Alternative Splicing GalleryENSG00000051620
Gene ExpressionHEBP2 [ NCBI-GEO ]   HEBP2 [ EBI - ARRAY_EXPRESS ]   HEBP2 [ SEEK ]   HEBP2 [ MEM ]
Gene Expression Viewer (FireBrowse)HEBP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23593
GTEX Portal (Tissue expression)HEBP2
Human Protein AtlasENSG00000051620-HEBP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y5Z4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y5Z4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y5Z4
Splice isoforms : SwissVarQ9Y5Z4
PhosPhoSitePlusQ9Y5Z4
Domains : Interpro (EBI)Reg_factor_effector_dom_sf    SOUL_haem-bd   
Domain families : Pfam (Sanger)SOUL (PF04832)   
Domain families : Pfam (NCBI)pfam04832   
Conserved Domain (NCBI)HEBP2
DMDM Disease mutations23593
Blocks (Seattle)HEBP2
PDB (SRS)3R85    3R8J    3R8K    4AYZ    4B0Y    5GQQ   
PDB (PDBSum)3R85    3R8J    3R8K    4AYZ    4B0Y    5GQQ   
PDB (IMB)3R85    3R8J    3R8K    4AYZ    4B0Y    5GQQ   
PDB (RSDB)3R85    3R8J    3R8K    4AYZ    4B0Y    5GQQ   
Structural Biology KnowledgeBase3R85    3R8J    3R8K    4AYZ    4B0Y    5GQQ   
SCOP (Structural Classification of Proteins)3R85    3R8J    3R8K    4AYZ    4B0Y    5GQQ   
CATH (Classification of proteins structures)3R85    3R8J    3R8K    4AYZ    4B0Y    5GQQ   
SuperfamilyQ9Y5Z4
Human Protein Atlas [tissue]ENSG00000051620-HEBP2 [tissue]
Peptide AtlasQ9Y5Z4
IPIIPI00003799   IPI00644697   IPI00513685   IPI00926661   IPI00926478   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y5Z4
IntAct (EBI)Q9Y5Z4
FunCoupENSG00000051620
BioGRIDHEBP2
STRING (EMBL)HEBP2
ZODIACHEBP2
Ontologies - Pathways
QuickGOQ9Y5Z4
Ontology : AmiGOprotein binding  extracellular region  cytoplasm  cytoplasm  mitochondrion  mitochondrion  negative regulation of mitochondrial membrane potential  negative regulation of mitochondrial membrane potential  positive regulation of necrotic cell death  positive regulation of necrotic cell death  heme binding  azurophil granule lumen  positive regulation of mitochondrial membrane permeability  positive regulation of mitochondrial membrane permeability  neutrophil degranulation  extracellular exosome  regulation of response to reactive oxygen species  
Ontology : EGO-EBIprotein binding  extracellular region  cytoplasm  cytoplasm  mitochondrion  mitochondrion  negative regulation of mitochondrial membrane potential  negative regulation of mitochondrial membrane potential  positive regulation of necrotic cell death  positive regulation of necrotic cell death  heme binding  azurophil granule lumen  positive regulation of mitochondrial membrane permeability  positive regulation of mitochondrial membrane permeability  neutrophil degranulation  extracellular exosome  regulation of response to reactive oxygen species  
NDEx NetworkHEBP2
Atlas of Cancer Signalling NetworkHEBP2
Wikipedia pathwaysHEBP2
Orthology - Evolution
OrthoDB23593
GeneTree (enSembl)ENSG00000051620
Phylogenetic Trees/Animal Genes : TreeFamHEBP2
HOVERGENQ9Y5Z4
HOGENOMQ9Y5Z4
Homologs : HomoloGeneHEBP2
Homology/Alignments : Family Browser (UCSC)HEBP2
Gene fusions - Rearrangements
Fusion : QuiverHEBP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHEBP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HEBP2
dbVarHEBP2
ClinVarHEBP2
1000_GenomesHEBP2 
Exome Variant ServerHEBP2
ExAC (Exome Aggregation Consortium)ENSG00000051620
GNOMAD BrowserENSG00000051620
Varsome BrowserHEBP2
Genetic variants : HAPMAP23593
Genomic Variants (DGV)HEBP2 [DGVbeta]
DECIPHERHEBP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHEBP2 
Mutations
ICGC Data PortalHEBP2 
TCGA Data PortalHEBP2 
Broad Tumor PortalHEBP2
OASIS PortalHEBP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHEBP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHEBP2
BioMutasearch HEBP2
DgiDB (Drug Gene Interaction Database)HEBP2
DoCM (Curated mutations)HEBP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HEBP2 (select a term)
intoGenHEBP2
Cancer3DHEBP2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605825   
Orphanet
DisGeNETHEBP2
MedgenHEBP2
Genetic Testing Registry HEBP2
NextProtQ9Y5Z4 [Medical]
TSGene23593
GENETestsHEBP2
Target ValidationHEBP2
Huge Navigator HEBP2 [HugePedia]
snp3D : Map Gene to Disease23593
BioCentury BCIQHEBP2
ClinGenHEBP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23593
Chemical/Pharm GKB GenePA25935
Clinical trialHEBP2
Miscellaneous
canSAR (ICR)HEBP2 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHEBP2
EVEXHEBP2
GoPubMedHEBP2
iHOPHEBP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:10:27 CET 2018

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