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HECA (hdc homolog, cell cycle regulator)

Identity

Alias_namesheadcase homolog (Drosophila)
Alias_symbol (synonym)HDCL
hHDC
HDC
dJ225E12.1
Other aliasHHDC
HGNC (Hugo) HECA
LocusID (NCBI) 51696
Atlas_Id 43581
Location 6q24.1  [Link to chromosome band 6q24]
Location_base_pair Starts at 139135112 and ends at 139180809 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CLPB (11q13.4) / HECA (6q24.1)HECA (6q24.1) / FMO4 (1q24.3)LCN1 (9q34.3) / HECA (6q24.1)
PTPRK (6q22.33) / HECA (6q24.1)RARS2 (6q15) / HECA (6q24.1)TSNAX (1q42.2) / HECA (6q24.1)
PTPRK 6q22.33 / HECA 6q24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(q22;q24) PTPRK/HECA


External links

Nomenclature
HGNC (Hugo)HECA   21041
Cards
Entrez_Gene (NCBI)HECA  51696  hdc homolog, cell cycle regulator
AliasesHDC; HDCL; HHDC; dJ225E12.1
GeneCards (Weizmann)HECA
Ensembl hg19 (Hinxton)ENSG00000112406 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112406 [Gene_View]  ENSG00000112406 [Sequence]  chr6:139135112-139180809 [Contig_View]  HECA [Vega]
ICGC DataPortalENSG00000112406
TCGA cBioPortalHECA
AceView (NCBI)HECA
Genatlas (Paris)HECA
WikiGenes51696
SOURCE (Princeton)HECA
Genetics Home Reference (NIH)HECA
Genomic and cartography
GoldenPath hg38 (UCSC)HECA  -     chr6:139135112-139180809 +  6q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HECA  -     6q24.1   [Description]    (hg19-Feb_2009)
EnsemblHECA - 6q24.1 [CytoView hg19]  HECA - 6q24.1 [CytoView hg38]
Mapping of homologs : NCBIHECA [Mapview hg19]  HECA [Mapview hg38]
OMIM607977   
Gene and transcription
Genbank (Entrez)AB033492 AJ420550 BC070068
RefSeq transcript (Entrez)NM_016217
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HECA
Cluster EST : UnigeneHs.197644 [ NCBI ]
CGAP (NCI)Hs.197644
Alternative Splicing GalleryENSG00000112406
Gene ExpressionHECA [ NCBI-GEO ]   HECA [ EBI - ARRAY_EXPRESS ]   HECA [ SEEK ]   HECA [ MEM ]
Gene Expression Viewer (FireBrowse)HECA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51696
GTEX Portal (Tissue expression)HECA
Human Protein AtlasENSG00000112406-HECA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBI9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBI9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBI9
Splice isoforms : SwissVarQ9UBI9
PhosPhoSitePlusQ9UBI9
Domains : Interpro (EBI)Headcase    Headcase_mid   
Domain families : Pfam (Sanger)Headcase (PF16002)    HECA (PF15353)   
Domain families : Pfam (NCBI)pfam16002    pfam15353   
Conserved Domain (NCBI)HECA
DMDM Disease mutations51696
Blocks (Seattle)HECA
SuperfamilyQ9UBI9
Human Protein Atlas [tissue]ENSG00000112406-HECA [tissue]
Peptide AtlasQ9UBI9
HPRD16265
IPIIPI00008202   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBI9
IntAct (EBI)Q9UBI9
FunCoupENSG00000112406
BioGRIDHECA
STRING (EMBL)HECA
ZODIACHECA
Ontologies - Pathways
QuickGOQ9UBI9
Ontology : AmiGOmolecular_function  nucleus  cytoplasm  membrane  respiratory tube development  negative regulation of mitotic cell cycle  negative regulation of mitotic cell cycle  
Ontology : EGO-EBImolecular_function  nucleus  cytoplasm  membrane  respiratory tube development  negative regulation of mitotic cell cycle  negative regulation of mitotic cell cycle  
NDEx NetworkHECA
Atlas of Cancer Signalling NetworkHECA
Wikipedia pathwaysHECA
Orthology - Evolution
OrthoDB51696
GeneTree (enSembl)ENSG00000112406
Phylogenetic Trees/Animal Genes : TreeFamHECA
HOVERGENQ9UBI9
HOGENOMQ9UBI9
Homologs : HomoloGeneHECA
Homology/Alignments : Family Browser (UCSC)HECA
Gene fusions - Rearrangements
Fusion : MitelmanPTPRK/HECA [6q22.33/6q24.1]  [t(6;6)(q22;q24)]  
Fusion PortalPTPRK 6q22.33 HECA 6q24.1 BRCA
Fusion : QuiverHECA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHECA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HECA
dbVarHECA
ClinVarHECA
1000_GenomesHECA 
Exome Variant ServerHECA
ExAC (Exome Aggregation Consortium)ENSG00000112406
GNOMAD BrowserENSG00000112406
Varsome BrowserHECA
Genetic variants : HAPMAP51696
Genomic Variants (DGV)HECA [DGVbeta]
DECIPHERHECA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHECA 
Mutations
ICGC Data PortalHECA 
TCGA Data PortalHECA 
Broad Tumor PortalHECA
OASIS PortalHECA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHECA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHECA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HECA
DgiDB (Drug Gene Interaction Database)HECA
DoCM (Curated mutations)HECA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HECA (select a term)
intoGenHECA
Cancer3DHECA(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607977   
Orphanet
DisGeNETHECA
MedgenHECA
Genetic Testing Registry HECA
NextProtQ9UBI9 [Medical]
TSGene51696
GENETestsHECA
Target ValidationHECA
Huge Navigator HECA [HugePedia]
snp3D : Map Gene to Disease51696
BioCentury BCIQHECA
ClinGenHECA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51696
Chemical/Pharm GKB GenePA134977625
Clinical trialHECA
Miscellaneous
canSAR (ICR)HECA (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHECA
EVEXHECA
GoPubMedHECA
iHOPHECA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:10:27 CET 2018

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