HECTD1 (HECT domain E3 ubiquitin protein ligase 1)

2014-11-01  

Identity

HGNC
LOCATION
14q12
LOCUSID
ALIAS
EULIR
FUSION GENES

Other Information

Locus ID:

NCBI: 25831
MIM: 618649
HGNC: 20157
Ensembl: ENSG00000092148

Variants:

dbSNP: 25831
ClinVar: 25831
TCGA: ENSG00000092148
COSMIC: HECTD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000092148ENST00000399332Q9ULT8
ENSG00000092148ENST00000553700Q9ULT8
ENSG00000092148ENST00000553957H0YJP0
ENSG00000092148ENST00000554471A0A087WVU6
ENSG00000092148ENST00000554882H0YJD4
ENSG00000092148ENST00000555915H0YJ72
ENSG00000092148ENST00000556224G3V4V5
ENSG00000092148ENST00000557369H0YJV8
ENSG00000092148ENST00000611816A0A087X2H1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
232773592013HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.32
295406742018circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1.17
246676072014Basic Tilted Helix Bundle - a new protein fold in human FKBP25/FKBP3 and HectD1.8
280733782017HECTD1 controls the protein level of IQGAP1 to regulate the dynamics of adhesive structures.5
293060772018The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages.5
317996322020HECTD1 promotes base excision repair in nucleosomes through chromatin remodelling.0

Citation

Dessen P

HECTD1 (HECT domain E3 ubiquitin protein ligase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64227/hectd1