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HECTD2 (HECT domain E3 ubiquitin protein ligase 2)

Identity

Alias_namesHECT domain containing E3 ubiquitin protein ligase 2
Alias_symbol (synonym)FLJ37306
Other alias-
HGNC (Hugo) HECTD2
LocusID (NCBI) 143279
Atlas_Id 46697
Location 10q23.32  [Link to chromosome band 10q23]
Location_base_pair Starts at 91410285 and ends at 91514828 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
C2CD2 (21q22.3) / HECTD2 (10q23.32)CTNNA3 (10q21.3) / HECTD2 (10q23.32)GRID1 (10q23.1) / HECTD2 (10q23.32)
HECTD2 (10q23.32) / GLRX3 (10q26.3)HECTD2 (10q23.32) / PCGF5 (10q23.32)TNKS2 (10q23.32) / HECTD2 (10q23.32)
GRID1 10q23.1 / HECTD2 10q23.32HECTD2 10q23.32 / GLRX3 10q26.3HECTD2 10q23.32 / PCGF5 10q23.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HECTD2   26736
Cards
Entrez_Gene (NCBI)HECTD2  143279  HECT domain E3 ubiquitin protein ligase 2
Aliases
GeneCards (Weizmann)HECTD2
Ensembl hg19 (Hinxton)ENSG00000165338 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165338 [Gene_View]  chr10:91410285-91514828 [Contig_View]  HECTD2 [Vega]
ICGC DataPortalENSG00000165338
TCGA cBioPortalHECTD2
AceView (NCBI)HECTD2
Genatlas (Paris)HECTD2
WikiGenes143279
SOURCE (Princeton)HECTD2
Genetics Home Reference (NIH)HECTD2
Genomic and cartography
GoldenPath hg38 (UCSC)HECTD2  -     chr10:91410285-91514828 +  10q23.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HECTD2  -     10q23.32   [Description]    (hg19-Feb_2009)
EnsemblHECTD2 - 10q23.32 [CytoView hg19]  HECTD2 - 10q23.32 [CytoView hg38]
Mapping of homologs : NCBIHECTD2 [Mapview hg19]  HECTD2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF131793 AK094625 AK122629 AK295723 AL713675
RefSeq transcript (Entrez)NM_001284274 NM_001348365 NM_173497 NM_182765
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HECTD2
Cluster EST : UnigeneHs.596096 [ NCBI ]
CGAP (NCI)Hs.596096
Alternative Splicing GalleryENSG00000165338
Gene ExpressionHECTD2 [ NCBI-GEO ]   HECTD2 [ EBI - ARRAY_EXPRESS ]   HECTD2 [ SEEK ]   HECTD2 [ MEM ]
Gene Expression Viewer (FireBrowse)HECTD2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)143279
GTEX Portal (Tissue expression)HECTD2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5U5R9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5U5R9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5U5R9
Splice isoforms : SwissVarQ5U5R9
Catalytic activity : Enzyme2.3.2.26 [ Enzyme-Expasy ]   2.3.2.262.3.2.26 [ IntEnz-EBI ]   2.3.2.26 [ BRENDA ]   2.3.2.26 [ KEGG ]   
PhosPhoSitePlusQ5U5R9
Domaine pattern : Prosite (Expaxy)HECT (PS50237)   
Domains : Interpro (EBI)HECT_dom   
Domain families : Pfam (Sanger)HECT (PF00632)   
Domain families : Pfam (NCBI)pfam00632   
Domain families : Smart (EMBL)HECTc (SM00119)  
Conserved Domain (NCBI)HECTD2
DMDM Disease mutations143279
Blocks (Seattle)HECTD2
SuperfamilyQ5U5R9
Human Protein AtlasENSG00000165338
Peptide AtlasQ5U5R9
HPRD13643
IPIIPI00291138   IPI00940836   IPI00465401   IPI00166319   IPI00646473   
Protein Interaction databases
DIP (DOE-UCLA)Q5U5R9
IntAct (EBI)Q5U5R9
FunCoupENSG00000165338
BioGRIDHECTD2
STRING (EMBL)HECTD2
ZODIACHECTD2
Ontologies - Pathways
QuickGOQ5U5R9
Ontology : AmiGOprotein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  cytosol  
Ontology : EGO-EBIprotein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  cytosol  
NDEx NetworkHECTD2
Atlas of Cancer Signalling NetworkHECTD2
Wikipedia pathwaysHECTD2
Orthology - Evolution
OrthoDB143279
GeneTree (enSembl)ENSG00000165338
Phylogenetic Trees/Animal Genes : TreeFamHECTD2
HOVERGENQ5U5R9
HOGENOMQ5U5R9
Homologs : HomoloGeneHECTD2
Homology/Alignments : Family Browser (UCSC)HECTD2
Gene fusions - Rearrangements
Fusion : MitelmanGRID1/HECTD2 [10q23.1/10q23.32]  [t(10;10)(q23;q23)]  
Fusion : MitelmanHECTD2/GLRX3 [10q23.32/10q26.3]  [t(10;10)(q23;q26)]  
Fusion : MitelmanHECTD2/PCGF5 [10q23.32/10q23.32]  [t(10;10)(q23;q23)]  
Fusion: TCGAGRID1 10q23.1 HECTD2 10q23.32 SKCM
Fusion: TCGAHECTD2 10q23.32 GLRX3 10q26.3 BRCA
Fusion: TCGAHECTD2 10q23.32 PCGF5 10q23.32 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHECTD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HECTD2
dbVarHECTD2
ClinVarHECTD2
1000_GenomesHECTD2 
Exome Variant ServerHECTD2
ExAC (Exome Aggregation Consortium)HECTD2 (select the gene name)
Genetic variants : HAPMAP143279
Genomic Variants (DGV)HECTD2 [DGVbeta]
DECIPHERHECTD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHECTD2 
Mutations
ICGC Data PortalHECTD2 
TCGA Data PortalHECTD2 
Broad Tumor PortalHECTD2
OASIS PortalHECTD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHECTD2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHECTD2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HECTD2
DgiDB (Drug Gene Interaction Database)HECTD2
DoCM (Curated mutations)HECTD2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HECTD2 (select a term)
intoGenHECTD2
Cancer3DHECTD2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenHECTD2
Genetic Testing Registry HECTD2
NextProtQ5U5R9 [Medical]
TSGene143279
GENETestsHECTD2
Target ValidationHECTD2
Huge Navigator HECTD2 [HugePedia]
snp3D : Map Gene to Disease143279
BioCentury BCIQHECTD2
ClinGenHECTD2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD143279
Chemical/Pharm GKB GenePA134933711
Clinical trialHECTD2
Miscellaneous
canSAR (ICR)HECTD2 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHECTD2
EVEXHECTD2
GoPubMedHECTD2
iHOPHECTD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:36:36 CEST 2017

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