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HECTD2 (HECT domain E3 ubiquitin protein ligase 2)

Identity

Alias (NCBI)-
HGNC (Hugo) HECTD2
HGNC Alias symbFLJ37306
HGNC Previous nameHECT domain containing E3 ubiquitin protein ligase 2
LocusID (NCBI) 143279
Atlas_Id 46697
Location 10q23.32  [Link to chromosome band 10q23]
Location_base_pair Starts at 91410285 and ends at 91514828 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C2CD2 (21q22.3) / HECTD2 (10q23.32)CTNNA3 (10q21.3) / HECTD2 (10q23.32)GRID1 (10q23.1) / HECTD2 (10q23.32)
HECTD2 (10q23.32) / GLRX3 (10q26.3)HECTD2 (10q23.32) / PCGF5 (10q23.32)TNKS2 (10q23.32) / HECTD2 (10q23.32)
GRID1 10q23.1 / HECTD2 10q23.32HECTD2 10q23.32 / GLRX3 10q26.3HECTD2 10q23.32 / PCGF5 10q23.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)HECTD2   26736
Cards
Entrez_Gene (NCBI)HECTD2    HECT domain E3 ubiquitin protein ligase 2
Aliases
GeneCards (Weizmann)HECTD2
Ensembl hg19 (Hinxton)ENSG00000165338 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165338 [Gene_View]  ENSG00000165338 [Sequence]  chr10:91410285-91514828 [Contig_View]  HECTD2 [Vega]
ICGC DataPortalENSG00000165338
TCGA cBioPortalHECTD2
AceView (NCBI)HECTD2
Genatlas (Paris)HECTD2
SOURCE (Princeton)HECTD2
Genetics Home Reference (NIH)HECTD2
Genomic and cartography
GoldenPath hg38 (UCSC)HECTD2  -     chr10:91410285-91514828 +  10q23.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HECTD2  -     10q23.32   [Description]    (hg19-Feb_2009)
GoldenPathHECTD2 - 10q23.32 [CytoView hg19]  HECTD2 - 10q23.32 [CytoView hg38]
ImmunoBaseENSG00000165338
Genome Data Viewer NCBIHECTD2 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AF131793 AK094625 AK122629 AK295723 AL713675
RefSeq transcript (Entrez)NM_001284274 NM_001348365 NM_173497 NM_182765
Consensus coding sequences : CCDS (NCBI)HECTD2
Gene ExpressionHECTD2 [ NCBI-GEO ]   HECTD2 [ EBI - ARRAY_EXPRESS ]   HECTD2 [ SEEK ]   HECTD2 [ MEM ]
Gene Expression Viewer (FireBrowse)HECTD2 [ Firebrowse - Broad ]
GenevisibleExpression of HECTD2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)143279
GTEX Portal (Tissue expression)HECTD2
Human Protein AtlasENSG00000165338-HECTD2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5U5R9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5U5R9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5U5R9
PhosPhoSitePlusQ5U5R9
Domaine pattern : Prosite (Expaxy)HECT (PS50237)   
Domains : Interpro (EBI)HECT_dom    Hect_E3_ubiquitin_ligase   
Domain families : Pfam (Sanger)HECT (PF00632)   
Domain families : Pfam (NCBI)pfam00632   
Domain families : Smart (EMBL)HECTc (SM00119)  
Conserved Domain (NCBI)HECTD2
SuperfamilyQ5U5R9
AlphaFold pdb e-kbQ5U5R9   
Human Protein Atlas [tissue]ENSG00000165338-HECTD2 [tissue]
HPRD13643
Protein Interaction databases
DIP (DOE-UCLA)Q5U5R9
IntAct (EBI)Q5U5R9
BioGRIDHECTD2
STRING (EMBL)HECTD2
ZODIACHECTD2
Ontologies - Pathways
QuickGOQ5U5R9
Ontology : AmiGOprotein polyubiquitination  ubiquitin-protein transferase activity  cytosol  
Ontology : EGO-EBIprotein polyubiquitination  ubiquitin-protein transferase activity  cytosol  
NDEx NetworkHECTD2
Atlas of Cancer Signalling NetworkHECTD2
Wikipedia pathwaysHECTD2
Orthology - Evolution
OrthoDB143279
GeneTree (enSembl)ENSG00000165338
Phylogenetic Trees/Animal Genes : TreeFamHECTD2
Homologs : HomoloGeneHECTD2
Homology/Alignments : Family Browser (UCSC)HECTD2
Gene fusions - Rearrangements
Fusion : MitelmanGRID1/HECTD2 [10q23.1/10q23.32]  
Fusion : MitelmanHECTD2/GLRX3 [10q23.32/10q26.3]  
Fusion : MitelmanHECTD2/PCGF5 [10q23.32/10q23.32]  
Fusion : QuiverHECTD2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHECTD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HECTD2
dbVarHECTD2
ClinVarHECTD2
MonarchHECTD2
1000_GenomesHECTD2 
Exome Variant ServerHECTD2
GNOMAD BrowserENSG00000165338
Varsome BrowserHECTD2
ACMGHECTD2 variants
VarityQ5U5R9
Genomic Variants (DGV)HECTD2 [DGVbeta]
DECIPHERHECTD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHECTD2 
Mutations
ICGC Data PortalHECTD2 
TCGA Data PortalHECTD2 
Broad Tumor PortalHECTD2
OASIS PortalHECTD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHECTD2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHECTD2
Mutations and Diseases : HGMDHECTD2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHECTD2
DgiDB (Drug Gene Interaction Database)HECTD2
DoCM (Curated mutations)HECTD2
CIViC (Clinical Interpretations of Variants in Cancer)HECTD2
Cancer3DHECTD2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETHECTD2
MedgenHECTD2
Genetic Testing Registry HECTD2
NextProtQ5U5R9 [Medical]
GENETestsHECTD2
Target ValidationHECTD2
Huge Navigator HECTD2 [HugePedia]
ClinGenHECTD2
Clinical trials, drugs, therapy
MyCancerGenomeHECTD2
Protein Interactions : CTDHECTD2
Pharm GKB GenePA134933711
PharosQ5U5R9
Clinical trialHECTD2
Miscellaneous
canSAR (ICR)HECTD2
HarmonizomeHECTD2
DataMed IndexHECTD2
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHECTD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:12:14 CEST 2021

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