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HECW1 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1)

Identity

Alias_symbol (synonym)KIAA0322
NEDL1
Other alias
HGNC (Hugo) HECW1
LocusID (NCBI) 23072
Atlas_Id 47474
Location 7p14.1  [Link to chromosome band 7p14]
Location_base_pair Starts at 43112599 and ends at 43563339 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
COA1 (7p13) / HECW1 (7p14.1)HECW1 (7p14.1) / HECW1 (7p14.1)HELZ (17q24.2) / HECW1 (7p14.1)
TRA2A (7p15.3) / HECW1 (7p14.1)C7orf44 HECW1 7p14.1TRA2A 7p15.3 / HECW1 7p14.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HECW1   22195
Cards
Entrez_Gene (NCBI)HECW1  23072  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
AliasesNEDL1
GeneCards (Weizmann)HECW1
Ensembl hg19 (Hinxton)ENSG00000002746 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000002746 [Gene_View]  chr7:43112599-43563339 [Contig_View]  HECW1 [Vega]
ICGC DataPortalENSG00000002746
TCGA cBioPortalHECW1
AceView (NCBI)HECW1
Genatlas (Paris)HECW1
WikiGenes23072
SOURCE (Princeton)HECW1
Genetics Home Reference (NIH)HECW1
Genomic and cartography
GoldenPath hg38 (UCSC)HECW1  -     chr7:43112599-43563339 +  7p14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HECW1  -     7p14.1   [Description]    (hg19-Feb_2009)
EnsemblHECW1 - 7p14.1 [CytoView hg19]  HECW1 - 7p14.1 [CytoView hg38]
Mapping of homologs : NCBIHECW1 [Mapview hg19]  HECW1 [Mapview hg38]
OMIM610384   
Gene and transcription
Genbank (Entrez)AB002320 AB048365 AK022679 AK090799 AK294918
RefSeq transcript (Entrez)NM_001287059 NM_015052
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HECW1
Cluster EST : UnigeneHs.164453 [ NCBI ]
CGAP (NCI)Hs.164453
Alternative Splicing GalleryENSG00000002746
Gene ExpressionHECW1 [ NCBI-GEO ]   HECW1 [ EBI - ARRAY_EXPRESS ]   HECW1 [ SEEK ]   HECW1 [ MEM ]
Gene Expression Viewer (FireBrowse)HECW1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23072
GTEX Portal (Tissue expression)HECW1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ76N89   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ76N89  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ76N89
Splice isoforms : SwissVarQ76N89
Catalytic activity : Enzyme2.3.2.26 [ Enzyme-Expasy ]   2.3.2.262.3.2.26 [ IntEnz-EBI ]   2.3.2.26 [ BRENDA ]   2.3.2.26 [ KEGG ]   
PhosPhoSitePlusQ76N89
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    HECT (PS50237)    WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domains : Interpro (EBI)C2_dom    HECT_dom    HECW_N    WW_dom   
Domain families : Pfam (Sanger)C2 (PF00168)    HECT (PF00632)    HECW_N (PF16562)    WW (PF00397)   
Domain families : Pfam (NCBI)pfam00168    pfam00632    pfam16562    pfam00397   
Domain families : Smart (EMBL)C2 (SM00239)  HECTc (SM00119)  WW (SM00456)  
Conserved Domain (NCBI)HECW1
DMDM Disease mutations23072
Blocks (Seattle)HECW1
PDB (SRS)3L4H   
PDB (PDBSum)3L4H   
PDB (IMB)3L4H   
PDB (RSDB)3L4H   
Structural Biology KnowledgeBase3L4H   
SCOP (Structural Classification of Proteins)3L4H   
CATH (Classification of proteins structures)3L4H   
SuperfamilyQ76N89
Human Protein AtlasENSG00000002746
Peptide AtlasQ76N89
HPRD11385
IPIIPI00173347   IPI00903326   IPI01012649   IPI00926322   IPI00925807   
Protein Interaction databases
DIP (DOE-UCLA)Q76N89
IntAct (EBI)Q76N89
FunCoupENSG00000002746
BioGRIDHECW1
STRING (EMBL)HECW1
ZODIACHECW1
Ontologies - Pathways
QuickGOQ76N89
Ontology : AmiGOcytosol  cytosol  protein ubiquitination  ubiquitin protein ligase activity  negative regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIcytosol  cytosol  protein ubiquitination  ubiquitin protein ligase activity  negative regulation of canonical Wnt signaling pathway  
NDEx NetworkHECW1
Atlas of Cancer Signalling NetworkHECW1
Wikipedia pathwaysHECW1
Orthology - Evolution
OrthoDB23072
GeneTree (enSembl)ENSG00000002746
Phylogenetic Trees/Animal Genes : TreeFamHECW1
HOVERGENQ76N89
HOGENOMQ76N89
Homologs : HomoloGeneHECW1
Homology/Alignments : Family Browser (UCSC)HECW1
Gene fusions - Rearrangements
Fusion : MitelmanCOA1/HECW1 [7p13/7p14.1]  [t(7;7)(p13;p14)]  
Fusion : MitelmanTRA2A/HECW1 [7p15.3/7p14.1]  [t(7;7)(p14;p15)]  
Fusion: TCGAC7orf44 HECW1 7p14.1 GBM
Fusion: TCGATRA2A 7p15.3 HECW1 7p14.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHECW1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HECW1
dbVarHECW1
ClinVarHECW1
1000_GenomesHECW1 
Exome Variant ServerHECW1
ExAC (Exome Aggregation Consortium)HECW1 (select the gene name)
Genetic variants : HAPMAP23072
Genomic Variants (DGV)HECW1 [DGVbeta]
DECIPHERHECW1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHECW1 
Mutations
ICGC Data PortalHECW1 
TCGA Data PortalHECW1 
Broad Tumor PortalHECW1
OASIS PortalHECW1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHECW1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHECW1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HECW1
DgiDB (Drug Gene Interaction Database)HECW1
DoCM (Curated mutations)HECW1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HECW1 (select a term)
intoGenHECW1
Cancer3DHECW1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610384   
Orphanet
MedgenHECW1
Genetic Testing Registry HECW1
NextProtQ76N89 [Medical]
TSGene23072
GENETestsHECW1
Huge Navigator HECW1 [HugePedia]
snp3D : Map Gene to Disease23072
BioCentury BCIQHECW1
ClinGenHECW1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23072
Chemical/Pharm GKB GenePA134964191
Clinical trialHECW1
Miscellaneous
canSAR (ICR)HECW1 (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHECW1
EVEXHECW1
GoPubMedHECW1
iHOPHECW1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:18:35 CEST 2017

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