HECW1 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1)

2007-04-01  

Identity

HGNC
LOCATION
7p14.1
LOCUSID
ALIAS
NEDL1
FUSION GENES

Other Information

Locus ID:

NCBI: 23072
MIM: 610384
HGNC: 22195
Ensembl: ENSG00000002746

Variants:

dbSNP: 23072
ClinVar: 23072
TCGA: ENSG00000002746
COSMIC: HECW1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000002746ENST00000395891Q76N89
ENSG00000002746ENST00000429529H7C3Q2
ENSG00000002746ENST00000453890Q76N89

Expression (GTEx)

0
1
2
3
4
5
6
7
8

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Degradation of DVLREACTOMER-HSA-4641258

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
146847392004NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1.45
268802002016Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway.21
182236812008A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-mediated apoptotic cell death in its catalytic activity-independent manner.19
211089312011RNF43 interacts with NEDL1 and regulates p53-mediated transcription.19
209762582011Muscle atrophy and motor neuron degeneration in human NEDL1 transgenic mice.12
212836212011The cytoskeletal protein Ndel1 regulates dynamin 2 GTPase activity.4
310570232019Changes E3 ubiquitin protein ligase 1 gene mRNA expression correlated with IgA1 glycosylation in patients with IgA nephropathy.2

Citation

Dessen P

HECW1 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47474/hecw1