Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HECW2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2)

Identity

Alias_symbol (synonym)KIAA1301
NEDL2
Other aliasNDHSAL
HGNC (Hugo) HECW2
LocusID (NCBI) 57520
Atlas_Id 47274
Location 2q32.3  [Link to chromosome band 2q32]
Location_base_pair Starts at 196194370 and ends at 196362222 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CORIN (4p12) / HECW2 (2q32.3)HECW2 (2q32.3) / SBF2 (11p15.4)LRP1B (2q22.1) / HECW2 (2q32.3)
STK17B (2q32.3) / HECW2 (2q32.3)LRP1B 2q22.1 / HECW2 2q32.3STK17B 2q32.3 / HECW2 2q32.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HECW2   29853
Cards
Entrez_Gene (NCBI)HECW2  57520  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
AliasesNDHSAL; NEDL2
GeneCards (Weizmann)HECW2
Ensembl hg19 (Hinxton)ENSG00000138411 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138411 [Gene_View]  chr2:196194370-196362222 [Contig_View]  HECW2 [Vega]
ICGC DataPortalENSG00000138411
TCGA cBioPortalHECW2
AceView (NCBI)HECW2
Genatlas (Paris)HECW2
WikiGenes57520
SOURCE (Princeton)HECW2
Genetics Home Reference (NIH)HECW2
Genomic and cartography
GoldenPath hg38 (UCSC)HECW2  -     chr2:196194370-196362222 -  2q32.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HECW2  -     2q32.3   [Description]    (hg19-Feb_2009)
EnsemblHECW2 - 2q32.3 [CytoView hg19]  HECW2 - 2q32.3 [CytoView hg38]
Mapping of homologs : NCBIHECW2 [Mapview hg19]  HECW2 [Mapview hg38]
OMIM617245   617268   
Gene and transcription
Genbank (Entrez)AB037722 AL390186 BC117194 BC117198 CR749424
RefSeq transcript (Entrez)NM_001304840 NM_001348768 NM_020760
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HECW2
Cluster EST : UnigeneHs.654742 [ NCBI ]
CGAP (NCI)Hs.654742
Alternative Splicing GalleryENSG00000138411
Gene ExpressionHECW2 [ NCBI-GEO ]   HECW2 [ EBI - ARRAY_EXPRESS ]   HECW2 [ SEEK ]   HECW2 [ MEM ]
Gene Expression Viewer (FireBrowse)HECW2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57520
GTEX Portal (Tissue expression)HECW2
Human Protein AtlasENSG00000138411-HECW2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P2P5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P2P5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P2P5
Splice isoforms : SwissVarQ9P2P5
Catalytic activity : Enzyme2.3.2.26 [ Enzyme-Expasy ]   2.3.2.262.3.2.26 [ IntEnz-EBI ]   2.3.2.26 [ BRENDA ]   2.3.2.26 [ KEGG ]   
PhosPhoSitePlusQ9P2P5
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    HECT (PS50237)    WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domains : Interpro (EBI)C2_dom    HECT_dom    HECW_N    WW_dom   
Domain families : Pfam (Sanger)C2 (PF00168)    HECT (PF00632)    HECW_N (PF16562)    WW (PF00397)   
Domain families : Pfam (NCBI)pfam00168    pfam00632    pfam16562    pfam00397   
Domain families : Smart (EMBL)C2 (SM00239)  HECTc (SM00119)  WW (SM00456)  
Conserved Domain (NCBI)HECW2
DMDM Disease mutations57520
Blocks (Seattle)HECW2
PDB (SRS)2LFE   
PDB (PDBSum)2LFE   
PDB (IMB)2LFE   
PDB (RSDB)2LFE   
Structural Biology KnowledgeBase2LFE   
SCOP (Structural Classification of Proteins)2LFE   
CATH (Classification of proteins structures)2LFE   
SuperfamilyQ9P2P5
Human Protein Atlas [tissue]ENSG00000138411-HECW2 [tissue]
Peptide AtlasQ9P2P5
HPRD17099
IPIIPI00017163   IPI00827974   IPI00918014   IPI00917859   
Protein Interaction databases
DIP (DOE-UCLA)Q9P2P5
IntAct (EBI)Q9P2P5
FunCoupENSG00000138411
BioGRIDHECW2
STRING (EMBL)HECW2
ZODIACHECW2
Ontologies - Pathways
QuickGOQ9P2P5
Ontology : AmiGOubiquitin-protein transferase activity  protein binding  cytoplasm  protein ubiquitination  regulation of mitotic metaphase/anaphase transition  mitotic spindle  
Ontology : EGO-EBIubiquitin-protein transferase activity  protein binding  cytoplasm  protein ubiquitination  regulation of mitotic metaphase/anaphase transition  mitotic spindle  
NDEx NetworkHECW2
Atlas of Cancer Signalling NetworkHECW2
Wikipedia pathwaysHECW2
Orthology - Evolution
OrthoDB57520
GeneTree (enSembl)ENSG00000138411
Phylogenetic Trees/Animal Genes : TreeFamHECW2
HOVERGENQ9P2P5
HOGENOMQ9P2P5
Homologs : HomoloGeneHECW2
Homology/Alignments : Family Browser (UCSC)HECW2
Gene fusions - Rearrangements
Fusion : MitelmanLRP1B/HECW2 [2q22.1/2q32.3]  [t(2;2)(q22;q33)]  
Fusion : MitelmanSTK17B/HECW2 [2q32.3/2q32.3]  [t(2;2)(q32;q33)]  
Fusion: TCGA_MDACCLRP1B 2q22.1 HECW2 2q32.3 LUSC
Fusion: TCGA_MDACCSTK17B 2q32.3 HECW2 2q32.3 BRCA
Tumor Fusion PortalHECW2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHECW2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HECW2
dbVarHECW2
ClinVarHECW2
1000_GenomesHECW2 
Exome Variant ServerHECW2
ExAC (Exome Aggregation Consortium)ENSG00000138411
GNOMAD BrowserENSG00000138411
Genetic variants : HAPMAP57520
Genomic Variants (DGV)HECW2 [DGVbeta]
DECIPHERHECW2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHECW2 
Mutations
ICGC Data PortalHECW2 
TCGA Data PortalHECW2 
Broad Tumor PortalHECW2
OASIS PortalHECW2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHECW2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHECW2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HECW2
DgiDB (Drug Gene Interaction Database)HECW2
DoCM (Curated mutations)HECW2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HECW2 (select a term)
intoGenHECW2
Cancer3DHECW2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617245    617268   
Orphanet
DisGeNETHECW2
MedgenHECW2
Genetic Testing Registry HECW2
NextProtQ9P2P5 [Medical]
TSGene57520
GENETestsHECW2
Target ValidationHECW2
Huge Navigator HECW2 [HugePedia]
snp3D : Map Gene to Disease57520
BioCentury BCIQHECW2
ClinGenHECW2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57520
Chemical/Pharm GKB GenePA134925001
Clinical trialHECW2
Miscellaneous
canSAR (ICR)HECW2 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHECW2
EVEXHECW2
GoPubMedHECW2
iHOPHECW2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:15:57 CET 2017

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