HELB (DNA helicase B)

2016-04-01  

Identity

HGNC
HELB
LOCATION
12q14.3
LOCUSID
92797
ALIAS
DHB,hDHB

Other Information

Locus ID:

NCBI: 92797
MIM: 614539
HGNC: 17196
Ensembl: ENSG00000127311

Variants:

dbSNP: 92797
ClinVar: 92797
TCGA: ENSG00000127311
COSMIC: HELB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127311ENST00000247815Q8NG08
ENSG00000127311ENST00000440906Q8NG08
ENSG00000127311ENST00000542394F5H1I4
ENSG00000127311ENST00000545134Q8NG08

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
267742852016HELB Is a Feedback Inhibitor of DNA End Resection.48
221946132012Human DNA helicase B (HDHB) binds to replication protein A and facilitates cellular recovery from replication stress.18
121813272002A dominant-negative mutant of human DNA helicase B blocks the onset of chromosomal DNA replication.17
259335142015Human DNA helicase B interacts with the replication initiation protein Cdc45 and facilitates Cdc45 binding onto chromatin.7
256178332015Human DNA helicase B functions in cellular homologous recombination and stimulates Rad51-mediated 5'-3' heteroduplex extension in vitro.6

Citation

Dessen P

HELB (DNA helicase B)

Atlas Genet Cytogenet Oncol Haematol. 2016-04-01

Online version: http://atlasgeneticsoncology.org/gene/55703/helb