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HELB (DNA helicase B)

Identity

Alias_nameshelicase (DNA) B
Other aliasDHB
hDHB
HGNC (Hugo) HELB
LocusID (NCBI) 92797
Atlas_Id 55703
Location 12q14.3  [Link to chromosome band 12q14]
Location_base_pair Starts at 66302545 and ends at 66343643 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HELB   17196
Cards
Entrez_Gene (NCBI)HELB  92797  DNA helicase B
AliasesDHB; hDHB
GeneCards (Weizmann)HELB
Ensembl hg19 (Hinxton)ENSG00000127311 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000127311 [Gene_View]  chr12:66302545-66343643 [Contig_View]  HELB [Vega]
ICGC DataPortalENSG00000127311
TCGA cBioPortalHELB
AceView (NCBI)HELB
Genatlas (Paris)HELB
WikiGenes92797
SOURCE (Princeton)HELB
Genetics Home Reference (NIH)HELB
Genomic and cartography
GoldenPath hg38 (UCSC)HELB  -     chr12:66302545-66343643 +  12q14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HELB  -     12q14.3   [Description]    (hg19-Feb_2009)
EnsemblHELB - 12q14.3 [CytoView hg19]  HELB - 12q14.3 [CytoView hg38]
Mapping of homologs : NCBIHELB [Mapview hg19]  HELB [Mapview hg38]
OMIM614539   
Gene and transcription
Genbank (Entrez)AA070301 AF319995 AK290894 BC037946 BC143409
RefSeq transcript (Entrez)NM_033647
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HELB
Cluster EST : UnigeneHs.505941 [ NCBI ]
CGAP (NCI)Hs.505941
Alternative Splicing GalleryENSG00000127311
Gene ExpressionHELB [ NCBI-GEO ]   HELB [ EBI - ARRAY_EXPRESS ]   HELB [ SEEK ]   HELB [ MEM ]
Gene Expression Viewer (FireBrowse)HELB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)92797
GTEX Portal (Tissue expression)HELB
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NG08   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NG08  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NG08
Splice isoforms : SwissVarQ8NG08
PhosPhoSitePlusQ8NG08
Domains : Interpro (EBI)Helb    P-loop_NTPase    UvrD-like_helicase_C   
Domain families : Pfam (Sanger)UvrD_C_2 (PF13538)   
Domain families : Pfam (NCBI)pfam13538   
Conserved Domain (NCBI)HELB
DMDM Disease mutations92797
Blocks (Seattle)HELB
SuperfamilyQ8NG08
Human Protein AtlasENSG00000127311
Peptide AtlasQ8NG08
HPRD09979
IPIIPI00168877   IPI00895894   IPI01012569   
Protein Interaction databases
DIP (DOE-UCLA)Q8NG08
IntAct (EBI)Q8NG08
FunCoupENSG00000127311
BioGRIDHELB
STRING (EMBL)HELB
ZODIACHELB
Ontologies - Pathways
QuickGOQ8NG08
Ontology : AmiGOATP-dependent RNA helicase activity  ATP binding  nucleus  alpha DNA polymerase:primase complex  DNA replication factor A complex  cytoplasm  DNA replication  DNA replication, synthesis of RNA primer  DNA repair  RNA processing  cellular response to DNA damage stimulus  single-stranded DNA-dependent ATP-dependent DNA helicase activity  DNA duplex unwinding  site of double-strand break  ATP-dependent 5'-3' DNA helicase activity  regulation of DNA double-strand break processing  negative regulation of double-strand break repair via homologous recombination  
Ontology : EGO-EBIATP-dependent RNA helicase activity  ATP binding  nucleus  alpha DNA polymerase:primase complex  DNA replication factor A complex  cytoplasm  DNA replication  DNA replication, synthesis of RNA primer  DNA repair  RNA processing  cellular response to DNA damage stimulus  single-stranded DNA-dependent ATP-dependent DNA helicase activity  DNA duplex unwinding  site of double-strand break  ATP-dependent 5'-3' DNA helicase activity  regulation of DNA double-strand break processing  negative regulation of double-strand break repair via homologous recombination  
NDEx NetworkHELB
Atlas of Cancer Signalling NetworkHELB
Wikipedia pathwaysHELB
Orthology - Evolution
OrthoDB92797
GeneTree (enSembl)ENSG00000127311
Phylogenetic Trees/Animal Genes : TreeFamHELB
HOVERGENQ8NG08
HOGENOMQ8NG08
Homologs : HomoloGeneHELB
Homology/Alignments : Family Browser (UCSC)HELB
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHELB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HELB
dbVarHELB
ClinVarHELB
1000_GenomesHELB 
Exome Variant ServerHELB
ExAC (Exome Aggregation Consortium)HELB (select the gene name)
Genetic variants : HAPMAP92797
Genomic Variants (DGV)HELB [DGVbeta]
DECIPHERHELB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHELB 
Mutations
ICGC Data PortalHELB 
TCGA Data PortalHELB 
Broad Tumor PortalHELB
OASIS PortalHELB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHELB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHELB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HELB
DgiDB (Drug Gene Interaction Database)HELB
DoCM (Curated mutations)HELB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HELB (select a term)
intoGenHELB
Cancer3DHELB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614539   
Orphanet
MedgenHELB
Genetic Testing Registry HELB
NextProtQ8NG08 [Medical]
TSGene92797
GENETestsHELB
Target ValidationHELB
Huge Navigator HELB [HugePedia]
snp3D : Map Gene to Disease92797
BioCentury BCIQHELB
ClinGenHELB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD92797
Chemical/Pharm GKB GenePA134987279
Clinical trialHELB
Miscellaneous
canSAR (ICR)HELB (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHELB
EVEXHELB
GoPubMedHELB
iHOPHELB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:36:37 CEST 2017

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