Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HELQ (helicase, POLQ-like)

Identity

Alias_symbol (synonym)Hel308
Other aliasHEL308
HGNC (Hugo) HELQ
LocusID (NCBI) 113510
Atlas_Id 53819
Location 4q21.23  [Link to chromosome band 4q21]
Location_base_pair Starts at 83407343 and ends at 83455883 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAM175A (4q21.23) / HELQ (4q21.23)HELQ (4q21.23) / FAM175A (4q21.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HELQ   18536
Cards
Entrez_Gene (NCBI)HELQ  113510  helicase, POLQ-like
AliasesHEL308
GeneCards (Weizmann)HELQ
Ensembl hg19 (Hinxton)ENSG00000163312 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163312 [Gene_View]  chr4:83407343-83455883 [Contig_View]  HELQ [Vega]
ICGC DataPortalENSG00000163312
TCGA cBioPortalHELQ
AceView (NCBI)HELQ
Genatlas (Paris)HELQ
WikiGenes113510
SOURCE (Princeton)HELQ
Genetics Home Reference (NIH)HELQ
Genomic and cartography
GoldenPath hg38 (UCSC)HELQ  -     chr4:83407343-83455883 -  4q21.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HELQ  -     4q21.23   [Description]    (hg19-Feb_2009)
EnsemblHELQ - 4q21.23 [CytoView hg19]  HELQ - 4q21.23 [CytoView hg38]
Mapping of homologs : NCBIHELQ [Mapview hg19]  HELQ [Mapview hg38]
OMIM606769   
Gene and transcription
Genbank (Entrez)AA150438 AF436845 AI627810 AK126255 AK128665
RefSeq transcript (Entrez)NM_001297755 NM_001297756 NM_001297757 NM_001297758 NM_001297759 NM_133636
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HELQ
Cluster EST : UnigeneHs.480101 [ NCBI ]
CGAP (NCI)Hs.480101
Alternative Splicing GalleryENSG00000163312
Gene ExpressionHELQ [ NCBI-GEO ]   HELQ [ EBI - ARRAY_EXPRESS ]   HELQ [ SEEK ]   HELQ [ MEM ]
Gene Expression Viewer (FireBrowse)HELQ [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)113510
GTEX Portal (Tissue expression)HELQ
Human Protein AtlasENSG00000163312-HELQ [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TDG4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TDG4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TDG4
Splice isoforms : SwissVarQ8TDG4
Catalytic activity : Enzyme3.6.4.12 [ Enzyme-Expasy ]   3.6.4.123.6.4.12 [ IntEnz-EBI ]   3.6.4.12 [ BRENDA ]   3.6.4.12 [ KEGG ]   
PhosPhoSitePlusQ8TDG4
Domaine pattern : Prosite (Expaxy)HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)DEAD (PF00270)    Helicase_C (PF00271)   
Domain families : Pfam (NCBI)pfam00270    pfam00271   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
Conserved Domain (NCBI)HELQ
DMDM Disease mutations113510
Blocks (Seattle)HELQ
SuperfamilyQ8TDG4
Human Protein Atlas [tissue]ENSG00000163312-HELQ [tissue]
Peptide AtlasQ8TDG4
HPRD08422
IPIIPI00152527   IPI00647582   IPI00889496   IPI00807650   IPI00965172   IPI00965450   
Protein Interaction databases
DIP (DOE-UCLA)Q8TDG4
IntAct (EBI)Q8TDG4
FunCoupENSG00000163312
BioGRIDHELQ
STRING (EMBL)HELQ
ZODIACHELQ
Ontologies - Pathways
QuickGOQ8TDG4
Ontology : AmiGOdouble-strand break repair via homologous recombination  DNA binding  ATP-dependent RNA helicase activity  ATP binding  RNA secondary structure unwinding  
Ontology : EGO-EBIdouble-strand break repair via homologous recombination  DNA binding  ATP-dependent RNA helicase activity  ATP binding  RNA secondary structure unwinding  
NDEx NetworkHELQ
Atlas of Cancer Signalling NetworkHELQ
Wikipedia pathwaysHELQ
Orthology - Evolution
OrthoDB113510
GeneTree (enSembl)ENSG00000163312
Phylogenetic Trees/Animal Genes : TreeFamHELQ
HOVERGENQ8TDG4
HOGENOMQ8TDG4
Homologs : HomoloGeneHELQ
Homology/Alignments : Family Browser (UCSC)HELQ
Gene fusions - Rearrangements
Tumor Fusion PortalHELQ
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHELQ [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HELQ
dbVarHELQ
ClinVarHELQ
1000_GenomesHELQ 
Exome Variant ServerHELQ
ExAC (Exome Aggregation Consortium)ENSG00000163312
GNOMAD BrowserENSG00000163312
Genetic variants : HAPMAP113510
Genomic Variants (DGV)HELQ [DGVbeta]
DECIPHERHELQ [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHELQ 
Mutations
ICGC Data PortalHELQ 
TCGA Data PortalHELQ 
Broad Tumor PortalHELQ
OASIS PortalHELQ [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHELQ  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHELQ
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HELQ
DgiDB (Drug Gene Interaction Database)HELQ
DoCM (Curated mutations)HELQ (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HELQ (select a term)
intoGenHELQ
Cancer3DHELQ(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606769   
Orphanet
DisGeNETHELQ
MedgenHELQ
Genetic Testing Registry HELQ
NextProtQ8TDG4 [Medical]
TSGene113510
GENETestsHELQ
Target ValidationHELQ
Huge Navigator HELQ [HugePedia]
snp3D : Map Gene to Disease113510
BioCentury BCIQHELQ
ClinGenHELQ
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD113510
Chemical/Pharm GKB GenePA164720529
Clinical trialHELQ
Miscellaneous
canSAR (ICR)HELQ (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHELQ
EVEXHELQ
GoPubMedHELQ
iHOPHELQ
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:15:57 CET 2017

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