Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

HELZ (helicase with zinc finger)

Identity

Alias_symbol (synonym)KIAA0054
HUMORF5
DHRC
Other aliasDRHC
HGNC (Hugo) HELZ
LocusID (NCBI) 9931
Atlas_Id 46523
Location 17q24.2  [Link to chromosome band 17q24]
Location_base_pair Starts at 65066554 and ends at 65241319 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FBF1 (17q25.1) / HELZ (17q24.2)HELZ (17q24.2) / ABCA10 (17q24.3)HELZ (17q24.2) / ATP2A2 (12q24.11)
HELZ (17q24.2) / C7orf25 (7p14.1)HELZ (17q24.2) / CACNG4 (17q24.2)HELZ (17q24.2) / CEP112 (17q24.1)
HELZ (17q24.2) / HECW1 (7p14.1)HELZ (17q24.2) / HELZ (17q24.2)HELZ (17q24.2) / P4HB (17q25.3)
HELZ (17q24.2) / PITPNC1 (17q24.2)HELZ (17q24.2) / PRPF40A (2q23.3)HELZ (17q24.2) / PTPRN (2q35)
HELZ (17q24.2) / TTYH2 (17q25.1)TIAM1 (21q22.11) / HELZ (17q24.2)FBF1 17q25.1 / HELZ 17q24.2
HELZ 17q24.2 / ABCA10 17q24.3HELZ 17q24.2 / CACNG4 17q24.2HELZ 17q24.2 / CEP112 17q24.1
HELZ 17q24.2 / PITPNC1 17q24.2HELZ 17q24.2 / TTYH2 17q25.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HELZ   16878
Cards
Entrez_Gene (NCBI)HELZ  9931  helicase with zinc finger
AliasesDHRC; DRHC; HUMORF5
GeneCards (Weizmann)HELZ
Ensembl hg19 (Hinxton)ENSG00000198265 [Gene_View]  chr17:65066554-65241319 [Contig_View]  HELZ [Vega]
Ensembl hg38 (Hinxton)ENSG00000198265 [Gene_View]  chr17:65066554-65241319 [Contig_View]  HELZ [Vega]
ICGC DataPortalENSG00000198265
TCGA cBioPortalHELZ
AceView (NCBI)HELZ
Genatlas (Paris)HELZ
WikiGenes9931
SOURCE (Princeton)HELZ
Genetics Home Reference (NIH)HELZ
Genomic and cartography
GoldenPath hg19 (UCSC)HELZ  -     chr17:65066554-65241319 -  17q24.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HELZ  -     17q24.2   [Description]    (hg38-Dec_2013)
EnsemblHELZ - 17q24.2 [CytoView hg19]  HELZ - 17q24.2 [CytoView hg38]
Mapping of homologs : NCBIHELZ [Mapview hg19]  HELZ [Mapview hg38]
OMIM606699   
Gene and transcription
Genbank (Entrez)AA885317 AI271466 AK310217 AK310639 AL110161
RefSeq transcript (Entrez)NM_014877
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)HELZ
Cluster EST : UnigeneHs.596366 [ NCBI ]
CGAP (NCI)Hs.596366
Alternative Splicing GalleryENSG00000198265
Gene ExpressionHELZ [ NCBI-GEO ]   HELZ [ EBI - ARRAY_EXPRESS ]   HELZ [ SEEK ]   HELZ [ MEM ]
Gene Expression Viewer (FireBrowse)HELZ [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9931
GTEX Portal (Tissue expression)HELZ
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42694   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP42694  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP42694
Splice isoforms : SwissVarP42694
Catalytic activity : Enzyme3.6.4.- [ Enzyme-Expasy ]   3.6.4.-3.6.4.- [ IntEnz-EBI ]   3.6.4.- [ BRENDA ]   3.6.4.- [ KEGG ]   
PhosPhoSitePlusP42694
Domaine pattern : Prosite (Expaxy)ZF_C3H1 (PS50103)   
Domains : Interpro (EBI)P-loop_NTPase    Znf_CCCH   
Domain families : Pfam (Sanger)zf-CCCH (PF00642)   
Domain families : Pfam (NCBI)pfam00642   
Domain families : Smart (EMBL)ZnF_C3H1 (SM00356)  
Conserved Domain (NCBI)HELZ
DMDM Disease mutations9931
Blocks (Seattle)HELZ
SuperfamilyP42694
Human Protein AtlasENSG00000198265
Peptide AtlasP42694
HPRD10452
IPIIPI00000897   IPI00941940   
Protein Interaction databases
DIP (DOE-UCLA)P42694
IntAct (EBI)P42694
FunCoupENSG00000198265
BioGRIDHELZ
STRING (EMBL)HELZ
ZODIACHELZ
Ontologies - Pathways
QuickGOP42694
Ontology : AmiGOhelicase activity  ATP binding  nucleus  metabolic process  membrane  poly(A) RNA binding  metal ion binding  
Ontology : EGO-EBIhelicase activity  ATP binding  nucleus  metabolic process  membrane  poly(A) RNA binding  metal ion binding  
NDEx NetworkHELZ
Atlas of Cancer Signalling NetworkHELZ
Wikipedia pathwaysHELZ
Orthology - Evolution
OrthoDB9931
GeneTree (enSembl)ENSG00000198265
Phylogenetic Trees/Animal Genes : TreeFamHELZ
HOVERGENP42694
HOGENOMP42694
Homologs : HomoloGeneHELZ
Homology/Alignments : Family Browser (UCSC)HELZ
Gene fusions - Rearrangements
Fusion : MitelmanFBF1/HELZ [17q25.1/17q24.2]  [t(17;17)(q24;q25)]  
Fusion : MitelmanHELZ/ABCA10 [17q24.2/17q24.3]  [t(17;17)(q24;q24)]  
Fusion : MitelmanHELZ/CACNG4 [17q24.2/17q24.2]  [t(17;17)(q24;q24)]  
Fusion : MitelmanHELZ/CEP112 [17q24.2/17q24.1]  [t(17;17)(q24;q24)]  
Fusion : MitelmanHELZ/PITPNC1 [17q24.2/17q24.2]  [t(17;17)(q24;q24)]  
Fusion : MitelmanHELZ/TTYH2 [17q24.2/17q25.1]  [t(17;17)(q24;q25)]  
Fusion: TCGAFBF1 17q25.1 HELZ 17q24.2 LUAD
Fusion: TCGAHELZ 17q24.2 ABCA10 17q24.3 BLCA
Fusion: TCGAHELZ 17q24.2 CACNG4 17q24.2 LUAD
Fusion: TCGAHELZ 17q24.2 CEP112 17q24.1 BLCA
Fusion: TCGAHELZ 17q24.2 PITPNC1 17q24.2 BRCA
Fusion: TCGAHELZ 17q24.2 TTYH2 17q25.1 BRCA
Fusion Cancer (Beijing)HELZ [17q24.2]  -  PRPF40A [2q23.3]  [FUSC000541]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHELZ [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HELZ
dbVarHELZ
ClinVarHELZ
1000_GenomesHELZ 
Exome Variant ServerHELZ
ExAC (Exome Aggregation Consortium)HELZ (select the gene name)
Genetic variants : HAPMAP9931
Genomic Variants (DGV)HELZ [DGVbeta]
DECIPHER (Syndromes)17:65066554-65241319  ENSG00000198265
CONAN: Copy Number AnalysisHELZ 
Mutations
ICGC Data PortalHELZ 
TCGA Data PortalHELZ 
Broad Tumor PortalHELZ
OASIS PortalHELZ [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHELZ  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHELZ
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HELZ
DgiDB (Drug Gene Interaction Database)HELZ
DoCM (Curated mutations)HELZ (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HELZ (select a term)
intoGenHELZ
Cancer3DHELZ(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606699   
Orphanet
MedgenHELZ
Genetic Testing Registry HELZ
NextProtP42694 [Medical]
TSGene9931
GENETestsHELZ
Huge Navigator HELZ [HugePedia]
snp3D : Map Gene to Disease9931
BioCentury BCIQHELZ
ClinGenHELZ
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9931
Chemical/Pharm GKB GenePA29238
Clinical trialHELZ
Miscellaneous
canSAR (ICR)HELZ (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHELZ
EVEXHELZ
GoPubMedHELZ
iHOPHELZ
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:03:35 CEST 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.