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HELZ (helicase with zinc finger)

Identity

Alias (NCBI)DHRC
DRHC
HUMORF5
HGNC (Hugo) HELZ
HGNC Alias symbKIAA0054
HUMORF5
DHRC
HGNC Alias namedown-regulated in human cancers
LocusID (NCBI) 9931
Atlas_Id 46523
Location 17q24.2  [Link to chromosome band 17q24]
Location_base_pair Starts at 67070444 and ends at 67245196 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FBF1 (17q25.1) / HELZ (17q24.2)HELZ (17q24.2) / ABCA10 (17q24.3)HELZ (17q24.2) / ATP2A2 (12q24.11)
HELZ (17q24.2) / C7orf25 (7p14.1)HELZ (17q24.2) / CACNG4 (17q24.2)HELZ (17q24.2) / CEP112 (17q24.1)
HELZ (17q24.2) / HECW1 (7p14.1)HELZ (17q24.2) / HELZ (17q24.2)HELZ (17q24.2) / P4HB (17q25.3)
HELZ (17q24.2) / PITPNC1 (17q24.2)HELZ (17q24.2) / PRPF40A (2q23.3)HELZ (17q24.2) / PTPRN (2q35)
HELZ (17q24.2) / TTYH2 (17q25.1)TIAM1 (21q22.11) / HELZ (17q24.2)FBF1 17q25.1 / HELZ 17q24.2
HELZ 17q24.2 / ABCA10 17q24.3HELZ 17q24.2 / CACNG4 17q24.2HELZ 17q24.2 / CEP112 17q24.1
HELZ 17q24.2 / PITPNC1 17q24.2HELZ 17q24.2 / TTYH2 17q25.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)HELZ   16878
Cards
Entrez_Gene (NCBI)HELZ    helicase with zinc finger
AliasesDHRC; DRHC; HUMORF5
GeneCards (Weizmann)HELZ
Ensembl hg19 (Hinxton)ENSG00000198265 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198265 [Gene_View]  ENSG00000198265 [Sequence]  chr17:67070444-67245196 [Contig_View]  HELZ [Vega]
ICGC DataPortalENSG00000198265
TCGA cBioPortalHELZ
AceView (NCBI)HELZ
Genatlas (Paris)HELZ
SOURCE (Princeton)HELZ
Genetics Home Reference (NIH)HELZ
Genomic and cartography
GoldenPath hg38 (UCSC)HELZ  -     chr17:67070444-67245196 -  17q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HELZ  -     17q24.2   [Description]    (hg19-Feb_2009)
GoldenPathHELZ - 17q24.2 [CytoView hg19]  HELZ - 17q24.2 [CytoView hg38]
ImmunoBaseENSG00000198265
Genome Data Viewer NCBIHELZ [Mapview hg19]  
OMIM606699   
Gene and transcription
Genbank (Entrez)AA885317 AI271466 AK310217 AK310639 AL110161
RefSeq transcript (Entrez)NM_001330447 NM_014877
Consensus coding sequences : CCDS (NCBI)HELZ
Gene ExpressionHELZ [ NCBI-GEO ]   HELZ [ EBI - ARRAY_EXPRESS ]   HELZ [ SEEK ]   HELZ [ MEM ]
Gene Expression Viewer (FireBrowse)HELZ [ Firebrowse - Broad ]
GenevisibleExpression of HELZ in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9931
GTEX Portal (Tissue expression)HELZ
Human Protein AtlasENSG00000198265-HELZ [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42694   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP42694  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP42694
Catalytic activity : Enzyme3.6.4.- [ Enzyme-Expasy ]   3.6.4.-3.6.4.- [ IntEnz-EBI ]   3.6.4.- [ BRENDA ]   3.6.4.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP42694
Domaine pattern : Prosite (Expaxy)ZF_C3H1 (PS50103)   
Domains : Interpro (EBI)DNA2/NAM7-like_C    DNA2/NAM7_AAA_11    P-loop_NTPase    Znf_CCCH    Znf_CCCH_sf   
Domain families : Pfam (Sanger)AAA_11 (PF13086)    AAA_12 (PF13087)    zf-CCCH (PF00642)   
Domain families : Pfam (NCBI)pfam13086    pfam13087    pfam00642   
Domain families : Smart (EMBL)ZnF_C3H1 (SM00356)  
Conserved Domain (NCBI)HELZ
SuperfamilyP42694
AlphaFold pdb e-kbP42694   
Human Protein Atlas [tissue]ENSG00000198265-HELZ [tissue]
HPRD10452
Protein Interaction databases
DIP (DOE-UCLA)P42694
IntAct (EBI)P42694
BioGRIDHELZ
STRING (EMBL)HELZ
ZODIACHELZ
Ontologies - Pathways
QuickGOP42694
Ontology : AmiGORNA binding  RNA binding  helicase activity  protein binding  ATP binding  nucleus  cytosol  membrane  hydrolase activity  post-transcriptional gene silencing by RNA  P granule  metal ion binding  
Ontology : EGO-EBIRNA binding  RNA binding  helicase activity  protein binding  ATP binding  nucleus  cytosol  membrane  hydrolase activity  post-transcriptional gene silencing by RNA  P granule  metal ion binding  
NDEx NetworkHELZ
Atlas of Cancer Signalling NetworkHELZ
Wikipedia pathwaysHELZ
Orthology - Evolution
OrthoDB9931
GeneTree (enSembl)ENSG00000198265
Phylogenetic Trees/Animal Genes : TreeFamHELZ
Homologs : HomoloGeneHELZ
Homology/Alignments : Family Browser (UCSC)HELZ
Gene fusions - Rearrangements
Fusion : MitelmanFBF1/HELZ [17q25.1/17q24.2]  
Fusion : MitelmanHELZ/ABCA10 [17q24.2/17q24.3]  
Fusion : MitelmanHELZ/CACNG4 [17q24.2/17q24.2]  
Fusion : MitelmanHELZ/CEP112 [17q24.2/17q24.1]  
Fusion : MitelmanHELZ/PITPNC1 [17q24.2/17q24.2]  
Fusion : MitelmanHELZ/TTYH2 [17q24.2/17q25.1]  
Fusion Cancer (Beijing)HELZ [17q24.2]  -  PRPF40A [2q23.3]  [FUSC000541]
Fusion : QuiverHELZ
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHELZ [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HELZ
dbVarHELZ
ClinVarHELZ
MonarchHELZ
1000_GenomesHELZ 
Exome Variant ServerHELZ
GNOMAD BrowserENSG00000198265
Varsome BrowserHELZ
ACMGHELZ variants
VarityP42694
Genomic Variants (DGV)HELZ [DGVbeta]
DECIPHERHELZ [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHELZ 
Mutations
ICGC Data PortalHELZ 
TCGA Data PortalHELZ 
Broad Tumor PortalHELZ
OASIS PortalHELZ [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHELZ  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHELZ
Mutations and Diseases : HGMDHELZ
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHELZ
DgiDB (Drug Gene Interaction Database)HELZ
DoCM (Curated mutations)HELZ
CIViC (Clinical Interpretations of Variants in Cancer)HELZ
Cancer3DHELZ
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606699   
Orphanet
DisGeNETHELZ
MedgenHELZ
Genetic Testing Registry HELZ
NextProtP42694 [Medical]
GENETestsHELZ
Target ValidationHELZ
Huge Navigator HELZ [HugePedia]
ClinGenHELZ
Clinical trials, drugs, therapy
MyCancerGenomeHELZ
Protein Interactions : CTDHELZ
Pharm GKB GenePA29238
PharosP42694
Clinical trialHELZ
Miscellaneous
canSAR (ICR)HELZ
HarmonizomeHELZ
DataMed IndexHELZ
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHELZ
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:12:16 CEST 2021

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