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HELZ2 (helicase with zinc finger 2)

Identity

Alias_nameshelicase with zinc finger 2, transcriptional coactivator
Alias_symbol (synonym)PDIP1
PRIC285
KIAA1769
Other aliasPDIP-1
HGNC (Hugo) HELZ2
LocusID (NCBI) 85441
Atlas_Id 64234
Location 20q13.33  [Link to chromosome band 20q13]
Location_base_pair Starts at 63558086 and ends at 63567754 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HELZ2   30021
Cards
Entrez_Gene (NCBI)HELZ2  85441  helicase with zinc finger 2
AliasesPDIP-1; PRIC285
GeneCards (Weizmann)HELZ2
Ensembl hg19 (Hinxton)ENSG00000130589 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130589 [Gene_View]  ENSG00000130589 [Sequence]  chr20:63558086-63567754 [Contig_View]  HELZ2 [Vega]
ICGC DataPortalENSG00000130589
TCGA cBioPortalHELZ2
AceView (NCBI)HELZ2
Genatlas (Paris)HELZ2
WikiGenes85441
SOURCE (Princeton)HELZ2
Genetics Home Reference (NIH)HELZ2
Genomic and cartography
GoldenPath hg38 (UCSC)HELZ2  -     chr20:63558086-63567754 -  20q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HELZ2  -     20q13.33   [Description]    (hg19-Feb_2009)
GoldenPathHELZ2 - 20q13.33 [CytoView hg19]  HELZ2 - 20q13.33 [CytoView hg38]
ImmunoBaseENSG00000130589
genome Data Viewer NCBIHELZ2 [Mapview hg19]  
OMIM611265   
Gene and transcription
Genbank (Entrez)AB051556 AB201715 AB232667 AF517673 AK023724
RefSeq transcript (Entrez)NM_001037335 NM_033405
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HELZ2
Alternative Splicing GalleryENSG00000130589
Gene ExpressionHELZ2 [ NCBI-GEO ]   HELZ2 [ EBI - ARRAY_EXPRESS ]   HELZ2 [ SEEK ]   HELZ2 [ MEM ]
Gene Expression Viewer (FireBrowse)HELZ2 [ Firebrowse - Broad ]
GenevisibleExpression of HELZ2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)85441
GTEX Portal (Tissue expression)HELZ2
Human Protein AtlasENSG00000130589-HELZ2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BYK8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BYK8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BYK8
Splice isoforms : SwissVarQ9BYK8
PhosPhoSitePlusQ9BYK8
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)   
Domains : Interpro (EBI)DNA2/NAM7-like_AAA    DNA2/NAM7_AAA_11    HELZ2    NA-bd_OB-fold    P-loop_NTPase    RNase_II/R    RNase_II/R_CS    Znf_C2H2_sf   
Domain families : Pfam (Sanger)AAA_11 (PF13086)    AAA_12 (PF13087)    RNB (PF00773)   
Domain families : Pfam (NCBI)pfam13086    pfam13087    pfam00773   
Domain families : Smart (EMBL)RNB (SM00955)  
Conserved Domain (NCBI)HELZ2
DMDM Disease mutations85441
Blocks (Seattle)HELZ2
SuperfamilyQ9BYK8
Human Protein Atlas [tissue]ENSG00000130589-HELZ2 [tissue]
Peptide AtlasQ9BYK8
HPRD11459
IPIIPI00249304   IPI00249305   IPI00736631   
Protein Interaction databases
DIP (DOE-UCLA)Q9BYK8
IntAct (EBI)Q9BYK8
FunCoupENSG00000130589
BioGRIDHELZ2
STRING (EMBL)HELZ2
ZODIACHELZ2
Ontologies - Pathways
QuickGOQ9BYK8
Ontology : AmiGOnuclear-transcribed mRNA catabolic process, nonsense-mediated decay  DNA binding  RNA binding  RNA binding  helicase activity  ribonuclease activity  protein binding  ATP binding  nucleoplasm  cytoplasm  membrane  regulation of lipid metabolic process  nuclear receptor transcription coactivator activity  positive regulation of transcription by RNA polymerase II  metal ion binding  RNA phosphodiester bond hydrolysis  
Ontology : EGO-EBInuclear-transcribed mRNA catabolic process, nonsense-mediated decay  DNA binding  RNA binding  RNA binding  helicase activity  ribonuclease activity  protein binding  ATP binding  nucleoplasm  cytoplasm  membrane  regulation of lipid metabolic process  nuclear receptor transcription coactivator activity  positive regulation of transcription by RNA polymerase II  metal ion binding  RNA phosphodiester bond hydrolysis  
NDEx NetworkHELZ2
Atlas of Cancer Signalling NetworkHELZ2
Wikipedia pathwaysHELZ2
Orthology - Evolution
OrthoDB85441
GeneTree (enSembl)ENSG00000130589
Phylogenetic Trees/Animal Genes : TreeFamHELZ2
HOGENOMQ9BYK8
Homologs : HomoloGeneHELZ2
Homology/Alignments : Family Browser (UCSC)HELZ2
Gene fusions - Rearrangements
Fusion : QuiverHELZ2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHELZ2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HELZ2
dbVarHELZ2
ClinVarHELZ2
1000_GenomesHELZ2 
Exome Variant ServerHELZ2
GNOMAD BrowserENSG00000130589
Varsome BrowserHELZ2
Genetic variants : HAPMAP85441
Genomic Variants (DGV)HELZ2 [DGVbeta]
DECIPHERHELZ2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHELZ2 
Mutations
ICGC Data PortalHELZ2 
TCGA Data PortalHELZ2 
Broad Tumor PortalHELZ2
OASIS PortalHELZ2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHELZ2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHELZ2
Mutations and Diseases : HGMDHELZ2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HELZ2
DgiDB (Drug Gene Interaction Database)HELZ2
DoCM (Curated mutations)HELZ2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HELZ2 (select a term)
intoGenHELZ2
Cancer3DHELZ2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611265   
Orphanet
DisGeNETHELZ2
MedgenHELZ2
Genetic Testing Registry HELZ2
NextProtQ9BYK8 [Medical]
TSGene85441
GENETestsHELZ2
Target ValidationHELZ2
Huge Navigator HELZ2 [HugePedia]
snp3D : Map Gene to Disease85441
BioCentury BCIQHELZ2
ClinGenHELZ2
Clinical trials, drugs, therapy
Protein Interactions : CTD85441
Pharm GKB GenePA166048993
Clinical trialHELZ2
Miscellaneous
canSAR (ICR)HELZ2 (select the gene name)
HarmonizomeHELZ2
DataMed IndexHELZ2
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHELZ2
EVEXHELZ2
GoPubMedHELZ2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri Jul 10 20:05:29 CEST 2020

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