HELZ2 (helicase with zinc finger 2)

2014-11-01  

Identity

HGNC
LOCATION
20q13.33
LOCUSID
ALIAS
PDIP-1,PRIC285

Other Information

Locus ID:

NCBI: 85441
MIM: 611265
HGNC: 30021
Ensembl: ENSG00000130589

Variants:

dbSNP: 85441
ClinVar: 85441
TCGA: ENSG00000130589
COSMIC: HELZ2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130589ENST00000427522Q9BYK8
ENSG00000130589ENST00000467148Q9BYK8

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial biogenesisREACTOMER-HSA-1592230
Transcriptional activation of mitochondrial biogenesisREACTOMER-HSA-2151201
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
YAP1- and WWTR1 (TAZ)-stimulated gene expressionREACTOMER-HSA-2032785
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108
RORA activates gene expressionREACTOMER-HSA-1368082
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Regulation of cholesterol biosynthesis by SREBP (SREBF)REACTOMER-HSA-1655829
Activation of gene expression by SREBF (SREBP)REACTOMER-HSA-2426168
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
224469642012Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles.217
235252312013THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation.12

Citation

Dessen P

HELZ2 (helicase with zinc finger 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64234/helz2